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Indolecarboxamidotetrazole compounds are well known as potential anti allergic agents due to their mast cell stabilizing activity on human basophils. A quantitative structure activity relationship (QSAR) model has been generated using Multiple Linear regression (MLR) for the prediction of inhibition efficiency of indolecarboxamidotetrazole derivatives. Twenty-one compounds with their activities ex

Identification of coexpressed genes is the central goal in microarray gene expression data analysis. Point symmetry-based clustering is an important unsupervised learning technique for recognizing symmetrical convex or non-convex shaped clusters. To enable fast automatic clustering of large microarray data, in this article, a distributed time-efficient scalable parallel rough set based hybrid appr

Identification of cancer pathways is the central goal in the cancer gene expression data analysis. A cellular automaton is a dynamic system with cells, which are uniform, interconnected and discrete in nature. Cellular automata are well-known methods to predict network traffics in cellular spaces. Therefore, to predict cancer pathways involved, we propose a 2-dimensional cellular automata approach

Point symmetry-based clustering is an important unsupervised learning tool for recognizing symmetrical convex or non-convex shaped clusters, even in the microarray datasets. To enable fast clustering of this large data, in this article, a distributed space and time-efficient scalable parallel approach for point symmetry-based K-means algorithm has been proposed. A natural basis for analyzing gene

Introduction: Product-oriented environmental law is an expanding, poly-thematic subsection of environmental law. First, an increasing number of policy instruments are being used at the international, European and national levels to regulate products, including mandatory performance standards, consumer subsidies, public procurement practices, product bans, taxes and charges and various kinds of man

This chapter examines the long-run relationship between public opinion, party politics, and the welfare state. It argues that when large parties receive a clear signal concerning the median voter’s position on the welfare state, vote-seeking motivations dominate and the large parties in the party system converge on the position of the median voter. When the position of the median voter is more dif

AD730TM is a novel superalloy developed for the hot section part in aero engine and gas turbine machinery with enhanced performance. The material is characterized by its excellent high temperature properties for being an alloy possible to manufacture by cast and wrought process compared to other superalloys in the same class such as Inconel718. The material with higher temperature capability means

A higher gas turbine efficiency can be achieved by increasing the operating temperature in hot sections. AD730™ is a recently-developed wrought/cast nickel-based superalloy which can maintain excellent mechanical properties above 700. However, machining of AD730™ could be a difficult task like other nickel-based superalloys. Therefore, studies are needed with respect to the machinability of this n

We consider multigrid methods for finite volume discretizations of the Reynolds averaged Navier–Stokes equations for both steady and unsteady flows. We analyze the effect of different smoothers based on pseudo time iterations, such as explicit and additive Runge–Kutta (AERK) methods. Furthermore, by deriving them from Rosenbrock smoothers, we identify some existing schemes as a class of additive W

A key challenge in developing bioinspired composites is the fabrication of well-defined 3D hierarchical structures ranging from nano to the macroscale. Herein, the development of a synthetic polymer-apatite composite realized by integrating bottom-up self-assembly and additive manufacturing (AM) is described. The resulting composite exhibits a bioinspired hierarchical structure over its 3D macrosc

Purpose: Doctoral student well-being is an important matter that shapes the well-being of academics throughout their careers. Given that well-being has been found to be closely related to employee productivity and efficiency, strategies associated with maintaining well-being during PhD studies might be crucial for higher education, its outcomes and—just as importantly—for a balanced life of PhD st

In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif

This study explores the impact of living with Parkinson's disease (PD). Nineteen persons (11 women) aged 55-84 diagnosed with PD 3-27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: "Changed prerequisites for managing day-

Protein-based encapsulation systems have a wide spectrum of applications in targeted delivery of cargo molecules and for chemical transformations in confined spaces. By engineering affinity between cargo and container proteins it has been possible to enable the efficient and specific encapsulation of target molecules. Missing in current approaches is the ability to turn off the interaction after e

BACKGROUND: The Self-Reported Foot and Ankle Score (SEFAS) is a foot- and ankle-specific patient-reported outcome measurement (PROM) score that has been validated with good results for a variety of foot and ankle disorders. SEFAS is sensitive detecting improvement or deterioration after surgery. However, normative values, required to put a specific patient's summary score into perspective, are lac

The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. Many of the actions of DHEAS are considered to be mediated through metabolism into androgens and estrogens in peripheral target tissues. The predictive value of serum DHEA and DHEAS for the likelihood of falling is unknown. T

Modern El Niño-Southern Oscillation (ENSO) events are characterized by their phase locking of variability to the seasonal cycle and tend to peak at the end of calendar year. Here, we show that in an idealized NCAR-CCSM3 simulation of the climate of the last 300,000 years, ENSO seasonal phase locking is shifted periodically following the precessional forcing: ENSO tends to peak in boreal winter whe