High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mitochondrial markers and function, as well as cognitive function, in a rat model of metabolic dysfunction. Eight-week-old male Wistar rats were subjected to either a control diet or a two-hit pr

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioproce

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif

Research on creative organizations often highlights a concern that economic influences on creative work might crowd out aesthetic influences. How this concern can be managed, however, is not well understood. Using a case study of an economic/aesthetic conflict within a design firm, we develop theory to describe how the economic and aesthetic can be constructively combined. We propose the concept o

Our title is a play on Nietzsche’s Schopenhauer as Educator first published in his essay collection Unfashionable Observations. Within the setting of teaching and studying management practice our chapter is also unfashionable. It argues for a primacy of honesty in feeling in a practice that can encourage the rational selection and manipulation of viewpoints. It argues for cheerful and generous exp

In this article we focus on the study of history through the use of narratives, within the context of the prevalent form of organization worldwide: the family business. Specifically we consider the dilemma of the impossible gift of succession using Nietzsche’s discussion of the burden of history and paralleling the story of a family business succession with that of Shakespeare’s King Lear. This wa

We challenge the obvious and easy association of enterprise and entrepreneurship. We do so by arguing that entrepreneurship is inherently social and collective, something that is concealed when held up as example of enterprising behaviour. We use as an illustrative case the Chinese artist Ai Weiwei, an example of entrepreneurship that has little to do with commerce and everything to do with the so

Purpose – This paper is a study of creating organization in the case of cultural projects; cultural entrepreneurship. This includes taking advantage of opportunities and using ones social capital through networks. It is a case study of Vandalorum which is an Swedish international art and design centre with a strong regional connection. They want to offer close collaborations between artists, desig

Process studies put movement, change and flow first; to study processually is to consider the world as restless, something underway, becoming and perishing, without end. To understand firms processually is to accept but also – and this is harder perhaps – to absorb this fluidity, to treat a variable as just that, a variable. The resonance with entrepreneurship studies is obvious. If any field is a

This article explores new forms of organizing (and organization creation) in relation to entrepreneurship and social transformation. In particular, in the dialogue that follows in this issue, we initiate a discussion regarding the ways through which social transformation is or can be related to community action and public and/or social entrepreneurship. By focusing on socioeconomic environments in