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Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that short-term treatment with the anti-estrogens tamoxifen or fulvestrant decrease cell proliferation but increase BC stem cell (BCSC) activity through JAG1-NOTCH4 receptor activation both in patient-derived samples and xenograft (PDX) tumors.

Even if outsourcing is a well-researched phenomenon, it can be stated that evaluation studies on IS outsourcing relationships are scarce. From a description of two IS outsourcing relationship cases, a set of les-sons learned are presented. A boundary spanning perspective is then used when evaluating these lessons learned in the client-supplier outsourcing relationships and thereby adding a “new” t

In this paper we employ the news aggregator Google News to demonstrate a strong link between the volatility in the stock market and the amount of news available to market participants. The paper also highlights some other areas, in finance and elsewhere, where news aggregators could be useful.

BACKGROUND: Despite their pivotal roles in colorectal carcinogenesis, the interrelationship and prognostic significance of beta-catenin alterations and microsatellite instability (MSI) in colorectal cancer (CRC) needs to be further clarified. In this paper, we studied the associations between beta-catenin overexpression and MSI status with survival from CRC, and with expression of p21, p27, cyclin

This study is a start to investigate the relationship between micro climate, i.e. the climate at the wood surface, and the wood moisture content. The micro climate is affected by the construction design; if water gets trapped in joints and stays on wood surfaces, the time during which water is absorbed by the wood increases. To be able to measure moisture content profiles and investigate the relat

An overview of the new field of Gas in Scattering Media Absorption Spectroscopy (GASMAS) is presented. The technique investigates sharp gas spectral signatures, typically 10000 times sharper than those of the host material, in which the gas is trapped in pores or cavities. The presence of pores causes strong multiple scattering. GASMAS combines narrow-band diode-laser spectroscopy, developed for a

Playing digital games is now a common everyday practice in many homes. This paper deals with the constitution of such practices by taking a closer look at the material objects essential to play and their role in the “design of everyday life” (Shove et al 2007). It uses ethnographic method and anthropological practice theory to attend to the domestic spaces of leisure and play, the home environment

Abstract in UndeterminedMinimum distances and maximum likelihood error probabilities of serial turbo codes with uniform interleaver are analyzed. It is shown that, for a fraction of interleavers approaching one as the block-length grows large, the minimum distance of serial turbo codes grows as a positive power of their block-length, while their error probability decreases exponentially fast in so

In view of the global increase in diabetes, and the fact that recent findings indicate that diabetic neuropathy is more frequently seen in males, it is crucial to evaluate any gender differences in nerve regeneration in diabetes. Our aim was to evaluate in short-term experiments gender dissimilarities in axonal outgrowth in healthy and in genetically developed type 2 diabetic Goto-Kakizaki (GK) ra

A measurement of the Z/gamma* transverse momentum (p(T)(Z)) distribution in proton-proton collisions at root s = 7 TeV is presented using Z/gamma* -> e(+)e(-) and Z/gamma* -> mu(+)mu(-) decays collected with the ATLAS detector in data sets with integrated luminosities of 35 pb(-1) and 40 pb(-1), respectively. The normalized differential cross sections are measured separately for electron and muon

Infrared polarization spectroscopy (IRPS) was used to detect HCl in an 800 mm long tube furnace. Pieces of a polyvinyl chloride-carpet were continuously fed into the furnace producing a heavy smoke, which is exemplified by the fact that the smoke completely obscured a red laser beam from a He-Ne laser. This constitutes a very harsh environment from a diagnostic point of view due to the high smoke

Although calcineurin inhibitors (CNIs) are effective at preventing a cute rejection, their long-term use is associated with nephrotoxicity that may compromise long-term renal allograft Survival. Consequently, there is considerable interest in identifying immunosuppressive regimens that permit reduced exposure to CNIs while maintaining adequate immunosuppression. Introducing such strategies early a

Aim: The aim of this study was to describe the relationship between occupational balance (measured by the occupational balance questionnaire [OBQ]) and self-rated health and life satisfaction. A secondary aim was to explore differences in occupational balance among adults in Sweden. Methods: The 153 participants (63% women), recruited using convenience sampling, answered a questionnaire comprising

In Sweden, 56% of the population aged 16-84 have an unhealthy lifestyle. The primary health care (PHC) has been instructed to offer citizens health promotion and disease-preventive actions. Very few studies have been conducted about how individuals experience interventions from the PHC intended to help them to change lifestyle.