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Pancreatic cancer remains one of the deadliest cancers due to its resistance to conventional therapies, necessitating the development of novel treatment strategies. This study investigates the anticancer potential of caulerpin, a bisindole alkaloid derived from the invasive marine alga Caulerpa cylindracea, encapsulated in biocompatible cubosomes. Caulerpin was sustainably extracted via microwave-

Background Pancreatic enzyme replacement therapy (PERT) prevents malnutrition in people with exocrine pancreatic insufficiency, including those with cystic fibrosis (CF). We developed a lipase that is stable against proteolysis and at the pH of the fed stomach, so it can be taken during a meal to promote mixing of enzyme and substrate. We designed a dose-ranging study of ANG003, a microbial PERT c

Parkinson’s disease (PD) is now recognized as a multisystem, heterogeneous neurodegenerative disease with fluctuating trajectories and complex symptom profiles. Despite therapeutic advances, many patients (particularly women and those in late stages) and their caregivers face substantial unmet needs across physical, psychological, social, and spiritual domains, which highlight the need for a more

BACKGROUND: Dapagliflozin improved cardiometabolic outcomes following myocardial infarction in patients without prior type-2 diabetes (T2DM) in the DAPA-MI (dapagliflozin in patients with myocardial infarction) trial. The effect of glycemic status and body mass index (BMI) post–myocardial infarction requires elucidation. METHODS: Participants with T2DM diagnosis, without baseline hemoglobin A1c, o

Fused Filament Fabrication (FFF) is an additive manufacturing (AM) process bringing many advantages over conventional processes such as allowing to obtain complex geometries and personalized designs at a lower cost. However, this process does not allow to reach tight surface roughness nor dimensional tolerances. To overcome these limits, post-production finishing techniques are required, such as f

Introduction: There is a lack of comprehensive data on complications following sinus surgery (SS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to estimate the prevalence of SS-related complications in CRSwNP patients and examine patient characteristics, predictors of revision surgery, healthcare use, and associated costs using secondary care data from Swedis

In superdeformed, heavy nuclei at low spins, M1 transitions enhanced by internal conversion are expected to compete favorably with E2 rays. For strongly coupled bands with fairly large B(M1) values, the decay may proceed between the two signature partner bands with very few rays emitted. Measured E2 ray intensities may imply strict limits on the M1 strength. Experimental evidence for the M1 cross

Examining the archaeological material of the modern period, over a period of the last 500 years, this open access book presents a series of case studies that challenges the fallacy of Nordic egalitarianism. The widening gap between rich and poor Western countries is now a well-known phenomenon and, while Scandinavia has often been hailed as one of the regions where inequality has been the lowest,

Background: This study aimed to assess chlamydia diagnostics in different clinic types, including internet-based self-sampling (IBSS). Furthermore, we investigated the incidence of chlamydia-associated complications. Methods: Data on Chlamydia trachomatis (CT) testing were retrieved from six healthcare regions in the years 2016–2023 across different categories of testing facilities. National data

Transdisciplinary research (TDR) integrates academic and non-academic expertise to co-produce actionable knowledge that contributes to societal impact in addressing sustainability challenges. While context is widely acknowledged as important, the role and definition of context factors shaping TDR remain underexplored. This study develops an integrative understanding of context by synthesising theo

The rigid triaxial rotor plus particle model (RTRP) was applied to the nucleus 125Xe in order to determine the value of the γ deformation. Two quantities are very sensitive to the γ deformation: the signature splitting of Yrast levels for negative parity levels (h1 1 2) and the lifetime of the (I= 7 2+, K= 7 2) isomer for positive parity lev els. From the two analyses one obtains the same value fo

High-spin states have been observed in the odd-odd isotope 120Cs in 32S-induced reactions. The previously known band is extended to higher spin and several new bands are identified. Band-head configurations have been inferred by comparing the band properties with known bands in the odd nuclei 121Cs and 121Ba. A remarkable signature inversion is observed in the πh 11 2⊗νh 11 2.

The hyperfine anomaly gives an insight into the coupling of spin and orbital magnetic moments in the nucleus. More precisely, the nuclear magnetization is expressible through the nuclear wave functions with which is tested not only the magnetic moment operator, but also the tensor product [s×C2]1. The experiment can then be expected to be of value in testing the nuclear structure theory. The great

The particle da- is used in various Arabic dialects to express a range of modal, future, progressive, habitual, optative and final functions. The present article analyzes the use of the particle da- in the dialect of Aleppo, for which it has thus far only been mentioned with a future and modal (want) function. An analysis of already published recordings from Behnstedt, along with one previously un

Background Small aortic annulus is associated with poorer hemodynamic outcomes in transcatheter aortic valve replacement (TAVR). In these cases, supra-annular (SA) self-expandable valves (SEVs) may offer better results than intra-annular SEVs (IA SEVs). This study evaluated clinical and hemodynamic outcomes for SA SEVs (Evolut valves, Acurate valves) and IA SEVs (Portico/Navitor valves). Methods W

Abstract: Lymphovascular invasion (LVI) in non-small cell lung cancer (NSCLC) is a critical prognostic marker linked to higher risks of metastasis and recurrence. This study aimed to develop a non-invasive predictive model using body composition features from 18F-FDG PET/CT imaging to assess LVI risk in early-stage NSCLC patients. Methods: We retrospectively analyzed 248 patients, including 153 fr

Relative properties of superdeformed bands are exploited in terms of the [effective] alignment of the valence particles. Observed and calculated quantities are compared leading to assignments of configurations and relative spins. Within one formalism, both typical differences between some bands and identity of other bands are understood.

An atomic beam magnetic resonance (ABMR) apparatus has been constructed at Orsay, and has been installed at the CERN PS Booster ISOLDE mass separator facility for "on-line" work with radioactive isotopes in a program to measure hyperfine structure anomalies (the Bohr-Weisskopf effect) over long isotopic chains. The hfs anomalies result from the effect of the spatial distribution of the nuclear mag

We have used the 8π γ-ray spectrometer at the Chalk River TASCC facility to study superdeformed rotational bands in the chain of isotopes 145-149Gd. The five bands already known have been extended to higher spin, while four new excited bands have been discovered. The use of very similar reactions, data-acquisition parameters and data-analysis techniques, combined with the enlarged set of data, has

The lifetimes of the three lowest excited members of the rotational ground-state band of103Mo at 102.6, 241.1 and 433.2 keV as well as of the levels at 353.8 and 456.1 keV have been determined through a measurement of the delayed coincidences between β particles from the decay of the parent103Nb and the γ rays which depopulate the levels. A plastic and a BaF2 detector have been used for the β and