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ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progenito

We present two new data structures for computing values of an n-variate polynomial P of degree at most d over a finite field of q elements. Assuming that d divides q-1, our first data structure relies on (d+1)n+2 tabulated values of P to produce the value of P at any of the qn points using O(nqd2) arithmetic operations in the finite field. Assuming that s divides d and d/s divides q-1, our second

Parkinson's disease (PD) is a neurodegenerative disorder characterized by typical motor features that result from dopamine (DA) depletion in the striatum. DA replacement therapy with L-DOPA is the most efficacious symptomatic treatment, but causes complications that limit its utility, in particular, L-DOPA-induced dyskinesia (LID). LID is primarily caused by pre-synaptic and post-synaptic changes

Swedish asthma guidelines recommend treating asthma with the lowest effective dose possible. These recommendations are both hard to follow and seldom considered enough in asthma care today. As an example, combination therapy with inhaled corticosteroids (ICS) and long acting beta agonists (LABA) should only be considered if asthma control is not achieved with low to medium dose ICS daily. However,

Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA).

The formalisation of customary land rights in Africa, as an alternative to their privatisation, is gaining increasing attention from scholars and policy makers. In this article, we use findings from Petauke district in eastern Zambia to discuss the impact of such reforms, where so-called traditional landholding certificates were implemented by the Petauke District Land Alliance in 2010. Based on i

The 1807 ban on the importation of slaves is said to have had severe consequences for farmers in South Africa’s Southwestern Cape, an areaof wheat and wine farming that used large numbers of slave labourers.The ban resulted in a rapid rise in slave prices, which signif icantly increased input costs. In contrast, the effect of the ban was apparently much more moderate in the eastern parts of the co

This article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the Camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, ScouThis article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, Scou

In this thesis diet and health of people who lived in southern Sweden 2300-1100 BCE is studied. The study is based on bioarchaeological analyses of human remains from 46 localities in the areas of Uppland, Närke, Östergötland, Västergötland, and Scania. The studies are based on skeletal remains from a minimum number of 310 individuals that have been analysed both osteologically and biochemically.

The accumulation of biofilms in porous media is likely to influence the overall hydraulic properties and, consequently, a sound understanding of the process is required for the proper design and management of many technological applications. In order to bring some light into this phenomenon we present a mechanistic model to study the variably saturated hydraulic properties of bio-amended soils. Sp

Self-branding is a central practice in the freelance labour market of the digital knowledge economy. Previous research suggests that self-branding is a form of affective and immaterial labour distinct to advanced capitalism (Arvidsson, 2006; Hearn, 2008). Social media offers a platform for celebrity experts to foster a distinct self-image, which can feed into their lifestyle brands (Gandini, 2016)

This chapter explores the brand of Islamic children’s literature produced in diaspora, in order to discern how this supplementary educational tool has responded to key concerns of Islamic education. How is Islamic faith staged in diasporic literary depiction? What innovative formats are employed and how does such innovation affect the content? Rather than understanding this literature in terms of

The current debate on armed Unmanned Aerial Vehicles (UAVs), also known as drones, focuses mostly on legal- and moral implications of their use. Issues such as civilian deaths, as well as the strategic implications and tactical advantages of drones are reigning supreme in the academic and public discussions. Yet these examinations fail to look at the wider implications of drone warfare. Through th

We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750 women between the ages of 12 and 86 years (average, 54.8 years). Clinically, 137