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Impact of the risk-adapted Nordic anal cancer group consensus guidelines on the contouring of the elective clinical target volume in anal cancer

Background and purpose: The recently published Nordic anal cancer group (NOAC) contouring guidelines aim for improved oncological outcomes and reduced toxicity in anal cancer patients treated with radiotherapy. The present work describes how the elective clinical target volume (CTVe) would change when applying the NOAC guidelines instead of the previous Australasian standard. According to the Aust

Status and perspective of protein crystallography at the first multi-bend achromat based synchrotron MAX IV

The first multi-bend achromat based synchrotron MAX IV operates two protein crystallography beamlines, BioMAX and MicroMAX. BioMAX is designed as a versatile, stable, high-throughput beamline catering for most protein crystallography experiments. MicroMAX is a more ambitious beamline dedicated to serial crystallography including time-resolved experiments. Both beamlines exploit the special charact

Prevalence of microspirometry-detected chronic obstructive pulmonary disease in two European cohorts of patients hospitalised for acute myocardial infarction : a cross-sectional study

Objectives To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI). Design Cross-sectional study. Setting Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). Participants 518 men or women (302 in Sweden

Pain management in preterm infants with necrotizing enterocolitis : an international expert consensus statement

Necrotizing enterocolitis (NEC) is probably the most painful intestinal disease affecting infants born preterm. NEC is known to cause highly severe and prolonged pain that has been associated with adverse short- and long-term effects. However, research on pain management in infants with NEC is scarce. This is likely due to its low incidence and very acute occurrence. As a result, the optimal pain

The Crucial Interplay Between the Lungs, Brain, and Heart to Understand Epilepsy-Linked SUDEP: A Literature Review : Brain Sciences

Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among individuals with epilepsy, particularly those with drug-resistant forms. This review explores the complex multisystem mechanisms underpinning SUDEP, integrating recent findings on brain, cardiac, and pulmonary dysfunctions. Background/Objectives: The main objective of this review is to elucidate how seizures disrupt

Men’s Experience of Abuse During Child- and Adulthood and Identification of Self as Perpetrator : A Cross-Sectional Study in Psychiatric Care

The aim of this study was to describe the extent to which men in psychiatric care have experienced emotional, physical, and sexual abuse during the life course and the association between this experience and being a perpetrator oneself. The aim was also to identify who exposed them to abuse and whether there was an association between the category of abuser and being a perpetrator oneself. A cross

Svårfångad lundaalumn kämpade för Ukraina

Kort biografisk artikel om kosackhetmanssonen, diplomaten, militären m m Georg Orlik (1702-1759) med tonvikt på dokumentationen kring dennes tid som student vid Lunds universitet.

Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers : a longitudinal cohort study

BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina

Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies

BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no

Apathy and affective symptoms associated with elevated plasma neurofilament light but not p-tau181 in Alzheimer's disease

INTRODUCTION: Apathy and affective neuropsychiatric symptoms (NPS) are prevalent in Alzheimer's disease (AD), yet their neurobiological cause is still unclear. We examined associations between plasma neurofilament light chain (NfL) and tau pathology (p-tau181) with apathy and affective symptoms in mild cognitive impairment (MCI) and AD dementia. METHODS: This longitudinal study analyzed data from

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope : A Randomized Sham-Controlled Trial

Background: Vasovagal syncope (VVS) is a common yet challenging condition with limited effective treatments. Elastic compression stockings (ECS) have been proposed as a potential therapy, but their real-world effectiveness remains unclear. Objectives: This study sought to compare the effectiveness of lower extremity compression with thigh-high ECS vs sham stockings for the prevention of VVS recurr

Multilevel small-area childhood stunting risk estimation: Insights from spatial ensemble learning, agro-ecological and environmentally remotely sensed indicators

Small area childhood stunting risk estimations remain a critical tool for shaping the surveillance policies of such a public health concern. With classical statistical methods, stunting risk metrics are mainly reported at a national level, which inhibits fine-scale insights at a more localized level. To this end, we implemented a novel multilevel small area estimation (SAE) approach for effectivel

Linear Regulator-based synchronization of positive discrete-time multi-agent systems

A fundamental challenge in control theory is designing protocols that achieve synchronization in interconnected systems. This paper addresses positive synchronization on undirected graphs for homogeneous discrete-time positive systems. It introduces a static feedback protocol derived from the Linear Regulator problem, where the stabilizing policy is determined by solving an algebraic equation usin