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Affärsrätten i centrum

Kapitlet innehåller en genomgång, framförallt utifrån ett förmögenhetsrättsligt perspektiv, av olika aktuella frågor inom den moderna affärsrätten. Utgångspunkten för kapitlet är att den nya ekonomin kräver nya spelregler men att affärsrätten också ska värna bestående rättsstatliga värden som rättvisa, förutsebarhet och rättssäkerhet. Det behandlar allmänna principer, etiken i affärsrätten och säg

Evaluating Interventions To Facilitate Human-Wildlife Coexistence.

Coexistence between humans and wildlife faces challenges for wildlife as well as human wellbeing and livelihoods. Learning, development, and transformative change in the adaptive use of management interventions across cultures and species are highly needed. This calls for thorough evaluation of interventions on both ecological and human dimensions parameters. Existing evaluations of management int

Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment

Streptococcus suis is an important meningitis-causing pathogen in pigs and humans. Neutrophil extracellular traps (NETs) have been identified as host defense mechanism against different pathogens. Here, NETs were detected in the cerebrospinal fluid (CSF) of S. suis-infected piglets despite the presence of active nucleases. To study NET-formation and NET-degradation after transmigration of S. suis

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly fac

Automatic determination of NET (neutrophil extracellular traps) coverage in fluorescent microscopy images

MOTIVATION: Neutrophil extracellular traps (NETs) are believed to be essential in controlling several bacterial pathogens. Quantification of NETs in vitro is an important tool in studies aiming to clarify the biological and chemical factors contributing to NET production, stabilization and degradation. This estimation can be performed on the basis of fluorescent microscopy images using appropriate

Streptococcus suis DNase SsnA contributes to degradation of neutrophil extracellular traps (NETs) and evasion of NET-mediated antimicrobial activity

Streptococcus suis is an important cause of different pathologies in pigs and humans, most importantly fibrinosuppurative meningitis. Tissue infected with this pathogen is substantially infiltrated with neutrophils, but the function of neutrophil extracellular traps (NETs) - a more recently discovered antimicrobial strategy of neutrophils - in host defence against Strep. suis has not been investig

Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth

The porcine and human pathogen Streptococcus suis induces and degrades neutrophil extracellular traps (NETs) in vitro. In this study, we investigated the working hypothesis that NET degradation is mediated not only by the known secreted S. suis nuclease A (SsnA) but also by a so-far undescribed putative endonuclease A of S. suis (designated EndAsuis) homologous to the pneumococcal endonuclease A (

Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs)

Neutrophil extracellular trap (NET) formation is described as a tool of the innate host defence to fight against invading pathogens. Fibre-like DNA structures associated with proteins such as histones, cell-specific enzymes and antimicrobial peptides are released, thereby entrapping invading pathogens. It has been reported that several bacteria are able to degrade NETs by nucleases and thus evade

Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps

The formation of neutrophil extracellular traps (NETs) as a host innate immune defence mechanism has been shown to be the result of a novel cell death process called NETosis. The objective of this study was to investigate the role of cholesterol in the formation of NETs. To this end, primary human neutrophils were treated with different concentrations of methy-β-cyclodetxrin (MβCD) to reduce chole

Recalcitrant carbon components in glomalin-related soil protein facilitate soil organic carbon preservation in tropical forests

Glomalin-related soil protein (GRSP) is known as an important microbial by-product which is crucial for preserving or accumulating soil organic carbon (SOC). However, the underlying mechanisms are not well understood. In this study, we investigated the chemical structures of GRSP and its relationship with SOC using 13C nuclear magnetic resonance (NMR) in three tropical forests. The three forests,

Agility in entrepreneurial projects

Managing entrepreneurship is of importance for the society, for organizations and for the individual. It is not enough with knowledge and skills relating to the idea behind entrepreneurship. The entrepreneur must have knowledge and skills to manage the entrepreneurial process. The purpose of this paper is to put forward for agile project management as an appropriate way to manage an entrepreneuria

Managing Project complexity - a managerial view

In this paper we are investigating how project complexity is affecting the management of single projects in a multi-project environment. The project manager’s perspective is applied. A conceptual framework is developed in order to summarize how project complexity effect project management. The framework is applied to two cases and conclusions are drawn.

Single amino acid substitutions in the selectivity filter render NbXIP1;1α aquaporin water permeable

BACKGROUND: Aquaporins (AQPs) are integral membrane proteins that facilitate transport of water and/or other small neutral solutes across membranes in all forms of life. The X Intrinsic Proteins (XIPs) are the most recently recognized and the least characterized aquaporin subfamily in higher plants. XIP1s have been shown to be impermeable to water but permeable to boric acid, glycerol, hydrogen pe

The specific costing problems of project form

Project costing is an area where more research is needed. Beginning from typical project characteristics discusses the specific costing problems of the project. The focus is on how those problems can be managed using activity-based costing. The article also takes up a short discussion about the critical moments of the project costing.