Synthesis, Function, and Inactivation of Blood Coagulation Factor V.
Blood coagulation factor V (FV) is a 330 kDa plasma glycoprotein. Activated FV (FVa) is a non-enzymatic cofactor to activated Factor X in the activation of prothrombin that occurs during coagulation. To investigate the molecular mechanisms of the quantitative FV deficiency associated with the FV R2 haplotype (a common genetic variant in several populations), four missense mutations identified in