Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped reads or known splice junctions. We identified 95,843 circRNAs, of which 20,441 were found recurrently. Of the circRNAs that match exon boundarie

En av de mest växande medicinska problemen i samhället är den allt ökande frakturfrekvensen i befolkningen. Vilka individer som drabbas av en frakturberor på ett samspel mellan en rad olika faktorer som benmassan, skelettarkitekturen, muskelstyrkan, muskelfunktionen, balansen och falltendensen. Det har övertygande visats att fysisk aktivitet kan påverka en rad av dessa riskfaktorer för fraktur. Ök

Om fysisk aktivitet har en roll att spela vid behandlingen av osteoporos utvärderas oftast genom att studera om träning minskar riskfaktorer för uppkomsten av en fraktur, exempelvis om träning ökar benmassan. Emellertid är riskfaktorer bara ersättningsvariabler för den enda egentliga acceptabla effektvariabeln – en fraktur - när träningens effekt skall utvärderas. Det är sålunda först om man kan v

Increased knowledge on familial melanoma and the underlying genetics Approximately 5-10 % of all melanoma patients have close relatives with melanoma. 5-20% of melanoma families have germline mutations in the CDKN2A gene. Swedish CDKN2A mutation carriers have a young median age of onset of melanoma, increased risks of multiple primary melanoma and of tobacco-associated cancers in respiratory and u

The Global Gridded Crop Model Intercomparison (GGCMI) phase 1 dataset of the Agricultural Model Intercomparison and Improvement Project (AgMIP) provides an unprecedentedly large dataset of crop model simulations covering the global ice-free land surface. The dataset consists of annual data fields at a spatial resolution of 0.5 arc-degree longitude and latitude. Fourteen crop modeling groups provid

Modern health-care is a complex socio-technical system, and as such variability is normal and necessary. The ability of a complex system such as health-care to quickly and correctly adapt to varying circumstances is crucial to how well the system works. Both increased compliance to guidelines, and a concurrent ability in individuals to deviate from these guidelines in certain situations, can be ex

To date, the best daylighting assessment technique is provided by climate-based simulation tools, which require remarkable efforts to create and calibrate realistic models. The data-driven approaches represent an interesting opportunity to support the physics-based modelling. This work proposes a novel method aimed at the optimization of energy use and luminous environment for a set of lighting co

Gestational diabetes mellitus (GDM) is today universally diagnosed during late pregnancy. Treating hyperglycaemia during pregnancy reduces the risk of complications, the effect of interventions is however limited due to the late diagnosis. It is thus important to identify biomarkers reaching a high precision for GDM development in early pregnancy. Here we aim to investigate soluble CD163 (sCD163)

The article presents some key aspects of the approach called sociology of philosophy, as represented by Pierre Bourdieu, Randall Colins and others. Comparisons are made with the philosophical research programme, developed by Dieter Henrich, which goes under the name constellation research. One thing that unites the sociology of philosophy and constellation research is an interest in antagonistic c

It has been shown that after production of oxophlorin, the first step of intermediate, both production of biliverdin and production of verdoheme occur simultaneously (Alavi et al. in Dalton Trans 47:8283–8291, 2018). So the mechanism that converts biliverdin into verdoheme is the subject of some controversy. The detailed conversion of verdoheme to biliverdin was demonstrated before by the Jerusal