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Haemophilia B (HB) is a rare inherited bleeding disorder caused by the deficiency of coagulation factor IX (FIX). The major clinical issues are bleedings, often targeting the joints, and the development of neutralising antibodies, i.e. inhibitors, to the FIX replacement therapy. Historically HB has been seen as identical to the more common haemophilia A (HA), i.e. deficiency of coagulation factor

The extent to which plants thermoregulate to maintain relatively stable metabolic function in response to gradual and rapid temperature changes that jeopardize crop production is unclear. Maize thermoregulation was investigated based on leaf temperature (TL) measurements and its relationship with photochemistry and stomatal conductance (gs) under dry and wet soil scenarios. Seasonal climatology wa

Införandet av människoexploateringsbrottet i 4 kap. 1 b § BrB aktualiserar ett antal frågor som tidigare inte behandlats i praxis. Bestämmelsen prövades för första gången av Högsta domstolen i NJA 2022 s. 23, vilket är det avgörande denna artikel kommenterar. Författaren visar att domstolen ställt upp en ordning för hur prövningen ska gå till, diskuterar innebörden av rekvisitet exploatering samt

We discuss our recent results on azimuthal distributions in vector boson + jets and multi-jet production at the LHC, obtained from the matching of next-to-leading order (NLO) perturbative matrix elements with transverse momentum dependent (TMD) parton branching. We present a comparative analysis of boson-jet and jet-jet correlations in the back-to-back region, and a study of the theoretical system

The ATLAS physics program at the High Luminosity LHC (HL-LHC) calls for a precision in the luminosity measurement of ±1%. A larger uncertainty would represent the dominant systematic error in some precision measurements, including the Higgs sector. To fulfil such requirement in an environment characterized by up to 140 simultaneous interactions per bunch crossing (200 in the ultimate scenario), AT

Förekomst av djup endometrios vid ultraljudsundersökning av infertila kvinnor

In addition to memory deficits and other cognitive disturbances, patients with Alzheimer's disease (AD) experience neuropsychiatric symptoms, notably apathy, which is a state of impaired motivation observed by deficits in goal directed behavior. Apathy is a multifaceted neuropsychiatric condition and appears to be a prognostic indicator, correlating with the progression of AD. Strikingly, recent s

The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.

High water consumption in the agricultural sector, population growth, urbanization, and industrialization have gradually turned groundwater into a quantitative and qualitative crisis. This study investigated aquifer storage and recovery (ASR) as the environmental effect of modernization projects in agricultural water distribution systems. For this purpose, a numerical model of the Qazvin Aquifer l

Observed winter near-surface air temperature anomalies in the Northern Hemisphere have exhibited a warm Arctic-cold Eurasia (WACE) pattern with interdecadal variation in recent decades, but the exact mechanism behind WACE is still under debate. This study used reanalysis data and climate model simulations to investigate the interdecadal variability of the WACE pattern on a centennial scale, as wel

Dissolved organic matter (DOM) was analyzed by its optical and fluorescent properties in order to study its distribution, source and transformation in relation to microbial abundances, chlorophyll and physicochemical gradients along a transect in the eastern Beagle Channel (BC) during austral spring 2019. Moreover, DOM evolution was followed during three tidal cycles in two fixed stations (F1, F2)

Purpose: To assess the growth plates of the knee in a healthy population of young adults and adolescents using DTI, and to correlate the findings with chronological age and skeletal maturation. Methods: A prospective, cross-sectional study to assess the tibial and femoral growth plates with DTI in 155 healthy volunteers aged between 14.0 and 21 years old. Echo-planar DTI with 15 directions and b v

Urban green spaces are important for climate change adaptation, in particular to reduce the negative impacts of heat waves on human well-being. However, in growing cities urban green spaces are under pressure due to increasing housing demand and densification. Municipalities face the challenge of addressing both the housing shortage and the need for climate change adaptation on limited space. This

Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s