BACKGROUND: A standardised technique using a suction-induced mini-erosion that allows serial sampling of dermal interstitial fluid (IF) for 5 to 6 days has been described. In the present study, we studied permeability changes as a function of time. METHODS: We examined IF concentrations of total protein concentration and the concentration of insulin (6.6 kDa), prealbumin (55 kDa), albumin (66 kDa)

Popular Abstract in Swedish Cirkulationen i de minsta kärlen, de s.k. mikrovaskulära utbyteskärlen är viktig för vävnadens syre- och näringstillförsel. Mikrocirkulationen utgörs av de minsta artärerna, kapillärerna, och de minsta venerna. I kapillärerna och i de minsta venerna sker utbytet av näring, syre, samt koldi-oxid och andra metabola restprodukter. För fettlösliga ämnen som koldioxid och syThis thesis presents some effects of Rho kinase, prostacyclin (PGI2) and nitric oxide (NO) in relation to trauma and inflammation by evaluating their effects on microvascular perfusion and permeability in mouse brain and in cat skeletal muscle. PGI2 and NO are endogenous vasoactive substances produced by the endothelium. They are vasodilators with antiaggregatory/antiadhesive and permeability-redu

Background: There are no predictors known that can identify COPD patients who will respond to treatment with ICS. Method: We investigated 30 patients (median age 65 (range 44-83, 12 females) with mild to moderately severe COPD. All patients had post bronchodilator FEV1/forced vital capacity ratio of less than 70% and a reversibility of less than 12% and 200 ml from baseline. We wanted to determine

ErbB1 and ErbB2 receptors are well-characterized targets for anticancer drugs, but the clinical relevance of the related ErbB4 receptor is unknown. Here, we have assessed the clinical significance of the proteolytically cleavable ErbB4 isoforms in breast cancer patients and investigated their functions in vitro. The expression of transcripts encoding the cleavable ErbB4 isoforms associated with es

Abstract is not available

Background. Gynecologic examination is a common measure in reproductive health care. Many women experience the examination as a more or less negative event, with shortcomings in the examiner's behavior. The aim of the study was to describe, in terms of critical incidences, women's experiences concerning the personnel's behavior in the situation of gynecologic examination. Methods. The informants w

give a short overview of what has been done in radiative and semileptonic Kaon decays in Chiral Perturbation Theory. This includes for semileptonic decays the work which has been done to order p6 including preliminary results of isospin breaking to that order in Kl3. For the radiative decays I mainly present some results from recent work concerning Kl3gamma.

The reaction between galena powder and ethylxanthate ions has been studied in aqueous solution. Qualitative analysis of the compounds present on the galena surfaces before and after treatment with potassium ethylxanthate has been performed by means of diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. Atomic absorption spectrophotometry has been used to determine the total lead c

An investigation of the influence of five DNA polymerase-buffer systems on real-time PCR showed that the choice of both DNA polymerase and the buffer system affected the amplification efficiency as well as the detection window. The analytical repeatability of the data for different systems changed clearly, leading us to conclude that basing quantitative measurements on single-data-set standard cur

Type 2 diabetes is characterised by both impaired insulin secretion and insulin resistance but their relative contribution to the development of hyperglycaemia may differ due to heterogeneity of the disease. Under most circumstances, insulin resistance is the earliest detectable defect in pre-diabetic individuals but it is not known whether this is the primary defect or secondary to other abnormal

The episcopate has been much debated in the twentieth century, both in the Church of Sweden and ecumenically. The purpose of the thesis is to study how it has been discussed within the Church of Sweden, using the priest and reformer Gunnar Rosendal (1897?1988) as point of departure. Methodologically speaking, a single individual is studied in order to shed light on a broad historical and ideologic

We outline a research methodology developed around two basic elements: the active discovery and/or creation of mysteries and the subsequent solving of the mysteries. A key element is the reflexive opening up of established theory and vocabulary through a systematic search for deviations from what would be expected. given established wisdom, in empirical contexts. "Data" are seen as an inspiration

Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4alpha (HNF4alpha) (the MODY1 gene) with risk for type 2 diabetes. We attempted to reproduce this putative association by genotyping 11 single nucleotide polymorphism (SNPs) spanning the HNF4a coding region and the P2 promoter in >3,400 patients and control subjects from Sweden, Fin

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