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Homotrimeric dUTPases; Structural Solutions for Specific Recognition and Hydrolysis of dUTP

Prevention of incorporation of dUTP into DNA is essential for maintenance of the genetic information. Prompt and specific removal of dUTP from the nucleotide pool, as expedited by the ubiquitous enzyme dUTPase, is therefore required for full viability in most biological systems. Conserved structural features perpetuate specificity in choice of substrate, which is crucial as hydrolysis of the struc

Photoelectron satellite structure from the 3d and 4d inner-shell ionization of rubidium and cesium: Role of atomic relaxation

The photoelectron satellite structure of rubidium and cesium has been investigated following the photoionization of an nd (n= 3,4) inner-shell electron. The intensity ratios of the nd(-1) ms monopole and nd(-1) m'p conjugated satellite lines have been measured at MAX-lab by using high-resolution electron spectroscopy. For rubidium, moreover, the energy dependence of the 3d(j)6s/3d(j)5s and 3d(j)5p

Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL

Constitutive activation of tyrosine kinases as a consequence of chromosomal translocations, forming fusion genes, plays an important role in the development of hematologic malignancies, in particular, myeloproliferative syndromes (MPSs). In this respect, the t(9;22)(q34;q11) that results in the BCR/ABL fusion gene in chronic myeloid leukemia is one of the best-studied examples. The fibroblast grow

Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF

In this study, we evaluated the possible use of lentiviral vectors in the treatment of neuropathic pain. We chose to administer GDNF-expressing vectors because of the known beneficial effect of this trophic factor in alleviation of neuropathic pain in adult rodents. Lentiviral vectors expressing either GDNF or control, green fluorescent protein or beta-galactosidase, were injected unilaterally int

On the stepwise change of activation energies in the hydrodechlorination of chlorobenzene over supported nickel

Kinetics of chlorobenzene hydrodechlorination have been measured over Ni on SiO2, Al2O3, MgO, activated carbon and graphite. A stepwise variation of E-a is analysed using the selective energy transfer model where E-a is identified as the vibrational energy associated with an excitation of the chlorobenzene out-of-plane C-H bending mode. Variation of E-a with vibrational quantum number yields a vib

Intra- and inter-rater reliability of the Sollerman hand function test in patients with chronic stroke

Purpose. To examine whether the Sollerman hand function test is reliable in a test-retest situation in patients with chronic stroke. Method. Three independent examiners observed each patient at three experimental sessions; two days in week I (short-term test-retest) and one day in week 4 (long-term test-retest). A total of 24 patients with chronic stroke (mean age; 59.7 years, mean time since stro

Fuel reserves affect migratory orientation of thrushes and sparrows both before and after crossing an ecological barrier near their breeding grounds

Fat reserves influence the orientation of migrating songbirds at ecological barriers, such as expansive water crossings. Upon encountering a body of water, fat migrants usually cross the barrier exhibiting 'forward' migration in a seasonally appropriate direction. In contrast, lean birds often exhibit temporary 'reverse' orientation away from the water, possibly to lead them to suitable habitats f

A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis.

Objective To compare the genetic regulation of collagen-induced arthritis (CIA) with that of pristane-induced arthritis (PIA) in rats. Methods A genome-wide linkage analysis of an (E3 × DA)DA backcross of rats with CIA (n = 364 male rats; the same strain combinations as previously used to determine the genetic control of PIA) was performed. The strongest loci in both CIA and PIA (i.e., Cia12/Pia4

Impact of different aspects of social participation and social capital on smoking cessation among daily smokers: a longitudinal study.

Objective: To investigate differences in different aspects of social participation and social capital among baseline daily smokers that had remained daily smokers, become intermittent smokers, or stopped smoking at one year follow up. Design/setting/participants/measurements: 12 507 individuals, aged 45–69 years, interviewed at baseline between 1992 and 1994 and at a one year follow up were inve

Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP

Since the sympathetic nervous system has been shown to exert a trophic influence on vascular smooth muscle cells (SMC), we studied the growth regulating effects of neuropeptide Y (NPY) in cooperation with the sympathetic co-transmitters noradrenaline and adenosine triphosphate (ATP) in human vascular SMC. NPY stimulated DNA synthesis in human SMC grown from subcutaneous arteries and veins (diamete

Weight-setting and quality assessment in simultaneous graphic generalization

Cartographic generalization aims at simplifying the representation of data to suit the scale and purpose of the map. This paper deals with a method that implements the whole graphic generalization process (roughly defined as the operators simplification, smoothing, exaggeration and displacement) called simultaneous graphic generalization. This method is based on constraints, i.e. requirements that

A multitechnique study of the interactions between H+, Na+, Ca2+ and Cu2+, and two types of softwood Kraft fibre materials

Aiming for a better understanding of the interactions between water suspended cellulose fibres and metal ions, this study was focused on characterising the interactions between Ca2+. Cu2+ and two different fibre materials-a fully bleached softwood Kraft pulp, and a chemically modified fully bleached softwood Kraft fibre material. The study was conducted as a function of pH (2-7), and both in the a

Air contaminants in a submarine equipped with air independent propulsion

The Swedish Navy has operated submarines equipped with air independent propulsion for two decades. This type of submarine can stay submerged for periods far longer than other nonnuclear submarines are capable of. The air quality during longer periods of submersion has so far not been thoroughly investigated. This study presents results for a number of air quality parameters obtained during more th

Decoration of amyloid fibrils with luminescent conjugated polymers

In this work we report the coating of a biological template with a polar, but uncharged,luminescent conjugated polymer, soluble in organic solvents but not in water, to produce a nanowire. Amyloid fibrils from bovine insulin were decorated with an alternating polyfluorene derivative. Decorated fibrils were partially aligned on hydrophobic surfaces as separate and bundled fibrils, by means of molec

Increased subpopulations of CD16(+) and CD56(+) blood monocytes in patients with active Crohn's disease

Background: Circulating monocytes may be subdivided according to the presence or absence of the Fc gamma receptor CD16 and the neural cell adhesion molecule CD56. Monocytes classified into these subpopulations Lire characterized by distinct phenotypic and functional features. We hypothesized that patients with active Crohn's disease differ in their peripheral monocyte subpopulations. Methods: Usin