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Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: influence of enriched environment.

Injury to the brain (e.g., stroke) results in a disruption of neuronal connectivity and loss of fundamental sensori-motor functions. The subsequent recovery of certain functions involves structural rearrangements in areas adjacent to the infarct. This remodeling of the injured brain requires trafficking of macromolecular components including cholesterol and phospholipids, a transport carried out b

Determining scaling in known phase diagrams of nonionic microemulsions to aid constructing unknown.

Microemulsions based on nonionic surfactants of the ethylene oxide alkyl ether type C(m)E(n), have been studied thoroughly for around 30years. Thanks to the considerable amount of published data available on these systems, it is possible to observe trends to make predictions of phase diagrams not yet determined. Strey and Kahlweit, and subsequently Sottmann and Strey, with coworkers have studied a

Labor Markets in Transformation: Case Studies of Latin America

This dissertation contains three independent studies that analyze labor markets in transformation. They focus on two central elements of labor markets in developing countries: non-agricultural employment in the rural economy and informal employment in the urban economy. Rural non-agricultural employment (RNAE) is being increasingly emphasized as a potential pathway out of rural poverty for people

The Associations of Advanced Glycation End Products and Its Soluble Receptor with Pancreatic Cancer Risk: A Case-Control Study within the Prospective EPIC Cohort.

BACKGROUND: Advanced glycation end products (AGE) and their receptors (RAGE) have been implicated in cancer development through their proinflammatory capabilities. However, prospective data on their association with cancer of specific sites, including pancreatic cancer, are limited.METHODS: Prediagnostic blood levels of the AGE product Nε-(carboxymethyl)lysine (CML) and the endogenous secreted rec

Mixed Micelles of a PEO-PPO-PEO Triblock Copolymer (P123) and a Nonionic Surfactant (C12EO6) in Water. A Dynamic and Static Light Scattering Study

The present article reports on static and dynamic light scattering (SLS and DLS) studies of aqueous solutions of the nonionic surfactant C12EO6 and the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer EO20PO68EO20 (P123) at temperatures between 25 and 45 degrees C. In water, P123 self-assembles into spherical micelles with a hydrodynamic radius of 10 nm, and at 40

Fiber-based dual-focus time-demultiplexed second harmonic generation microscopy

We present a dual-focus second harmonic generation (SHG) microscopy approach based on stable, compact, and inexpensive fiber technology. One-tenth of the fiber laser output is coupled into a 100 m (=500 ns) long single-mode fiber and further amplified to achieve two separately guided beams with time-alternating pulse trains. SHG detection is performed sequentially, generating two individual images

Search for molecular and metabolic mechanisms contributing to impaired β-cell function

Popular Abstract in Swedish Diabetes är en endokrin sjukdom som också kallas sockersjuka. Den kännetecknas av förhöjda mängder socker i blodet. Halten av socker i blodet, blodsockret, styrs av hormonet insulin, som produceras av β-celler i Langerhanska öar i bukspottskörteln. När insulin frisätts stimuleras muskler, fettväv och lever till att ta upp glukos ur blodet och lagra det. På så sätt sänksType 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for casual mechanisms underlying metabolic alterations disturbing insulin secretion. In paper

Screen Channel Liquid-Acquisition-Device Bubble Point Tests in Liquid Oxygen

This paper examines the key parameters that affect the bubble point pressure for screen channel liquid acquisition devices in cryogenic liquid oxygen at elevated pressures and temperatures typical of a high-pressure propellant tank. An in-depth analysis of the effect of varying liquid temperature, pressure, and pressurization gas type on the bubble point is presented. Testing of a 200 x 1400 and 3

Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma.

BACKGROUND: The molecular biology of renal cell carcinoma (RCC) is complex and not fully understood. We have recently found that the expression of the receptor tyrosine kinase Axl in the RCC tumors independently correlates with survival of the patients. PRINCIPAL FINDINGS: Here, we have investigated the role of Axl and its ligand Gas6, the vitamin-K dependent protein product of the growth arrest-s

Neural grafting in Parkinson's disease: problems and possibilities

Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits can be achieved. Subsequent studies, in particular two that followed a double-blin

In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial

Objective To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration <1 year) who had initially responded well to methotrexate monotherapy. Methods In the SWEFOT trial, all 487 patients started methotrexate (target dose 20 mg/week). After 3-4 months, 147 had low disease activity, 28-joint based disease activity score (DAS28) <= 3.