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The finding of a new genetic risk variant and the description of the exact underlying mechanism explains, on a molecular level, the connection between stress and diabetes. This scientific breakthrough is published online today in the journal Science. Carriers of the risk variant have stressed insulin producing cells which greatly reduces their ability to secrete insulin. Further, making the findin

https://www.ludc.lu.se/article/risk-gene-activates-stress-system-and-increases-risk-diabetes - 2025-10-05

Hyperglycemia starts a complex chain of events that damages blood vessels and cause cardiovascular disease. Scientists at Lund University Diabetes Centre (LUDC) have now been able to demonstrate why this happens, as well as how the destructive chain can be broken. This discovery represents a crucial step towards an efficient treatment of the vascular injuries that will be the cause of death for mo

https://www.ludc.lu.se/article/new-mechanism-underlying-cardiovascular-disease - 2025-10-05

Leif Groop, professor in diabetes and endocrinology at the Department of Clinical Sciences in Malmö, Lund University, has been elected to recipient of Hilda och Alfred Erikssons prize of year 2010. Leif Groop receives the prize "for pioneering research about Type 2 Diabetes" whcih is the motivation by the Academy of Science.- An honorable acknowledgement  and it is always nice to be appreciated fo

https://www.ludc.lu.se/article/royal-academy-science-praise-diabetes-professor - 2025-10-05

A recently discovered estrogen receptor in the insulin-producing cells may facilitate targeted diabetes treatment for women. The type 2 diabetes drugs that are currently available on the market have often only been tested on men. The identification of this new receptor may also explain why type 2 diabetes is less common in women than in men. "Estrogen is thought to have an important anti-diabetic

https://www.ludc.lu.se/article/female-hormone-protects-against-diabetes - 2025-10-05

Children of immigrants from countries with low risk of type 1 diabetes develop the disease more often than expected if they grow up in Sweden, which is a high-risk country. Scientists mean that it is something in the Swedish environment that causes this elevated risk. Ahmed Delli, who is a scientist at Lund University Diabetes Centre, has mapped what happens when a child moves from an area with lo

https://www.ludc.lu.se/article/moving-sweden-increases-risk-diabetes - 2025-10-05

Anders Rosengren, physician at Skåne University Hospital and researcher at Lund University Research Centre in Malmö, has received six and a half million swedish crowns from the Novo Nordisk Foundation Project of Excellence. - This means a lot. I can start a research group of my own and drive the research work faster, says Anders Rosengren.The project he presented and, in tough competition with oth

https://www.ludc.lu.se/article/large-research-grant-mapping-linkage-between-stress-and-diabetes - 2025-10-05

At the time of the atmospheric nuclear weapons testing in the 1950s and 1960s, the level of carbon-14 in the atmosphere increased dramatically. Now researchers from Lund University have developed a method for measuring the carbon-14 content in atherosclerotic plaques in patients. The measurements reveal how old and dangerous the plaques really are. "On the one hand it’s important to find out wheth

https://www.ludc.lu.se/article/nuclear-weapons-tests-provide-information-dangerous-atherosclerosis-plaque - 2025-10-05

All diabetics who developed the disease before the age of six months should be tested for a certain genetic mutation. Some of them might not need insulin injections but could manage their disease just as well, or better, with a simple tablet. “Neonatal diabetes is an uncommon form of diabetes caused by a genetic mutation, which means that insulin is not secreted in the right way”, says Sten Ivarss

https://www.ludc.lu.se/article/many-diabetics-could-manage-without-insulin-injections - 2025-10-05

A prestigious award to Olle Melander, researcher at Lund University Diabetes Centre and physician at Skåne University Hospital in Malmö. He is awarded the prestigious award Peter Sleight Award 2010. The award, which is handed out by the European Society of Hypertension, consists apart from the honor, also by 10.000 euro.- It is of course very honorable to get appreciation for what you do and that

https://www.ludc.lu.se/article/prestigious-award-cardiovascular-research - 2025-10-05

During regulation of blood glucose levels, various hormones interact and counteract with each other in a complex manner. Together, these hormones maintain stable glucose levels. The recent mapping of hormonal interactions, carried out by scientists at Lund University Diabetes Centre (LUDC), aimed to explain why an imbalance occurs and to increase our understanding of the causes of diabetes. Insuli

https://www.ludc.lu.se/article/stable-glucose-levels-are-result-complex-hormonal-balancing-act - 2025-10-05

For the first time, scientists are able to describe the exact mechanism for how a common genetic variant leads to a disruption in blood lipid levels that significantly increases the risk of heart disease. The one in every three persons who carries both copies of the risk allele engages a 40 percent higher risk of suffering a heart attack than persons who do not carry either copy of the risk allele

https://www.ludc.lu.se/article/mechanism-behind-common-heart-attack-gene-explained-scientific-breakthrough-nature - 2025-10-05

As a PhD student he made a significant discovery when he identified ghrelin cells in the pancreatic islands. Four hormone-producing cells were already known to exist in the islands, including the insulin cell. The ghrelin cell became the fifth such cell. “In the scientific world, the discovery of a new type of cell in a human organ is a big deal. So naturally this was an important find. Especially

https://www.ludc.lu.se/article/flying-start-fifth-cell - 2025-10-05

In competition with more than a thousand entries for the Presidential Poster Competition at the 2010 Endocrine Society congress in San Diego, USA, the winning contribution was that of Rajesh Kumar, scientist at Lund University Diabetes Centre. The research in question relates to the positive effects of the oestrogen hormone on the survival rates of insulin cells. Rajesh Kumar’s summary of the ongo

https://www.ludc.lu.se/article/oestrogen-protects-transplanted-cells-and-organs - 2025-10-05

The goal is set high, that during the coming ten years develop new methods to prevent, cure and treat diabetes. - Ambitious, but not unrealistic, says Leif Groop, coordinator for EXODIAB, the joint research project that Lund and Uppsala now will launch with a conference in Malmö September 9-10th. Wide range and conductingEXODIAB (Excellence Of Diabetes Research in Sweden) is one of the governments

https://www.ludc.lu.se/article/kick-large-venture-diabetes-research - 2025-10-05

Marju Orho-Melander, professor of genetic epidemiology in Malmö, has been awarded Lund University’s Fernström prize. Her research is about genetic variants that are associated with blood lipids and lipoproteins and can therefore increase the risk of cardiovascular disease. Many genes exist in different variants. Sometimes, some of the variants have a negative effect, in particular if they are comb

https://www.ludc.lu.se/article/lunds-fernstrom-prize-goes-research-genes - 2025-10-05

Leif Groop, professor in diabetes and endocrinology at Lund University Diabetes Centre and consultant at the Endocrinological Department at Skåne University Hospital Malmö, has been elected to the diabetologist of the year by the Swedish Society of Diabetology. - I am of course honored and happy that my work is appreciated, comments Leif Groop.In the motivation for the appointment his focus to ide

https://www.ludc.lu.se/article/leif-groop-diabetologist-year-2010 - 2025-10-05

An extensive global gene-mapping project has identified a large number of loci that dictate whether a person is tall or short. The aim of the project is to find out more about how many genes interact to form biologically interesting mechanisms behind diseases. "Height on its own is perhaps not tremendously interesting but it serves as a good indicator when determining how genetic mechanisms work",

https://www.ludc.lu.se/article/height-study-casts-light-genetic-mechanisms - 2025-10-05

TrialNet studies are now starting in Sweden, with the initial trials in Skåne. TrialNet is an international network of researchers who are investigating possible ways to prevent, delay and reverse the development of type 1 diabetes. The TrialNet network is currently made up of 18 research centres – in the USA, Canada, Finland, Sweden, the United Kingdom, Italy, Germany, Australia and New Zealand.

https://www.ludc.lu.se/article/are-you-related-someone-type-1-diabetes - 2025-10-05

Research groups in close collaboration in Malmö have shed light on the pathway whereby a common genetic risk variant leads to impaired mitochondrial function of insulin cells. The variant in question impairs the capacity to secrete insulin and increases the risk of developing diabetes. The discovery is published in the highly ranked scientific journal Cell Metabolism. It is widely established that

https://www.ludc.lu.se/article/disturbance-cellular-power-plant-increases-risk-diabetes - 2025-10-05

Researchers are now asking the question the other way around. They want to know why some diabetic patients do not develop complications. What is protecting them? The PROLONG study may provide the answer. - The majority of diabetics will over time develop severe or lethal complications, but 10-15 percent never do. They are the ones we are interested in the PROLONG study, explains Valeriya Lyssenko

https://www.ludc.lu.se/article/why-are-some-diabetics-free-complications - 2025-10-05