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Problem i forskarvärlden - många forskningsresultat kan inte upprepas

Att forskningsresultat ska kunna upprepas är en av vetenskapens grundläggande principer. Ändå visar flera genomgångar av vetenskapliga studier att det inte ser ut så. Kritiker pekar på flera orsaker och nu vill forskare minska fokus på publiceringshetsen för att minska felaktigheter. Hör mer på https://sverigesradio.se/artikel/7647634.

https://www.lupop.lu.se/article/problem-i-forskarvarlden-manga-forskningsresultat-kan-inte-upprepas - 2025-10-03

Exploring Traumatic Brain Injuries and Aggressive Antisocial Behaviors in Young Male Violent Offenders

Traumatic brain injury (TBI) is a major cause of disabilities and mortality worldwide, with higher prevalence in offender populations than in the general population. Previous research has strongly advocated increased awareness of TBI in offender populations. The aim of this study was to explore the prevalence and characteristics of TBI, and to investigate associations and interactions between TBI,

https://www.lupop.lu.se/article/exploring-traumatic-brain-injuries-and-aggressive-antisocial-behaviors-young-male-violent-offenders - 2025-10-03

Cadmium and Lead Levels in Blood and Arsenic Levels in Urine among Schoolchildren Living in Contaminated Glassworks Areas, Sweden

The Kingdom of Crystal, an area in southern Sweden famous for its many glassworks, is historically heavily burdened by pollution from this industry. Glass crust containing cadmium (Cd), lead (Pb), and arsenic (As) has been deposited around the area and used as filling. The purpose of this study was to monitor whether the high levels of metals in the contaminated soil were reflected in blood and ur

https://www.lupop.lu.se/article/cadmium-and-lead-levels-blood-and-arsenic-levels-urine-among-schoolchildren-living-contaminated - 2025-10-03

Identification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Ris

It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer–Cardiovascular Cohort

https://www.lupop.lu.se/article/identification-inflammatory-and-disease-associated-plasma-proteins-associate-intake-added-sugar-and - 2025-10-03

Malignancies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis: A Population-based Cohort Study

With case record review, the outcomes and malignancy development in a cohort of 195 patients with AAV [granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA] diagnosed between 1997 and 2010 were assessed. The patients were followed until death or December 31, 2015. The age- and sex-standardized incidence ratios (SIR) were estimated using the Swedish population data

https://www.lupop.lu.se/article/malignancies-patients-antineutrophil-cytoplasmic-antibody-associated-vasculitis-population-based - 2025-10-03

Parental questionnaires provided reliable data on childhood asthma compared with national registers

Data were obtained from the prospective, longitudinal, population‐based Children of Western Sweden cohort, which focused on children born in 2003. The parents answered questionnaires at six months and one, four, eight and 12 years of age. Personal identity numbers linked 3634 children to the Swedish Prescribed Drug Register (SPDR) and the National Patient Register (NPR). Read more at Parental ques

https://www.lupop.lu.se/article/parental-questionnaires-provided-reliable-data-childhood-asthma-compared-national-registers - 2025-10-03

Is reporting quality in medical publications associated with biostatisticians as co-authors? A registered report protocol

Quality in medical research has recently been criticized for being low, especially in observational research. Methodology is increasingly difficult, but collaboration between clinical researchers and biostatisticians may improve research and reporting quality. The aim of this study is to quantify the value of a biostatistician in the team of authors. Read more at Is reporting quality in medical pu

https://www.lupop.lu.se/article/reporting-quality-medical-publications-associated-biostatisticians-co-authors-registered-report - 2025-10-03

Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes

Analyses were based on Swedish case–control data comprising incident cases of LADA (n = 465) and T2D (n = 1528) with matched, population-based controls (n = 1789; n = 1553 in genetic analyses). Multivariable-adjusted ORs in relation to self-reported processed and unprocessed red meat intake were estimated by conditional logistic regression models. Attributable proportion (AP) due to interaction wa

https://www.lupop.lu.se/article/consumption-red-meat-genetic-susceptibility-and-risk-lada-and-type-2-diabetes - 2025-10-03

Familial risk of breast cancer by dynamic, accumulative, and static definitions of family history

The authors assessed the effect of incorporating the timing of cancer diagnosis events into the assessment of familial risks of breast cancer in first‐degree and second‐degree relatives in a nationwide cohort study of 5,099,172 women (follow‐up was between 1958‐2015). Family history was assessed using 3 approaches: 1) as a static variable (ever having a relative with breast cancer); 2) as accumula

https://www.lupop.lu.se/article/familial-risk-breast-cancer-dynamic-accumulative-and-static-definitions-family-history - 2025-10-03

Ulnar Nerve Entrapment in Diabetes: Patient-reported Outcome after Surgery in National Quality Registries.

Ulnar nerve entrapment at the elbow (UNE) is overrepresented in patients with diabetes, but the outcome of surgery is unknown. We aimed to evaluate patient-reported outcome in patients with and without diabetes, and to assess potential sex differences and compare surgical treatment methods. Data on patients operated for UNE (2010-2016, n = 1354) from the Swedish National Registry for Hand Surgery

https://www.lupop.lu.se/article/ulnar-nerve-entrapment-diabetes-patient-reported-outcome-after-surgery-national-quality-registries - 2025-10-03

RDA COVID-19 Recommendations and Guidelines for Data Sharing

The recommendations in the document are aimed at helping policymakers and funders to maximise timely, quality data sharing and appropriate responses in future health emergencies. The Research Data Alliance (RDA) COVID-19 Working Group members bring various, global expertise to develop a body of work that comprises how data from multiple disciplines inform response to a pandemic combined with guide

https://www.lupop.lu.se/article/rda-covid-19-recommendations-and-guidelines-data-sharing - 2025-10-03

Cancer survival statistics for patients and healthcare professionals – a tutorial of real‐world data analysis

In this review, we explain statistical concepts targeted towards patients, clinicians and healthcare professionals that summarize cancer patient survival under the assumption that other causes of death exist. Specifically, we explain the appropriate use, interpretation and assumptions behind statistical methods for competing risks, loss in life expectancy due to cancer and conditional survival. Re

https://www.lupop.lu.se/article/cancer-survival-statistics-patients-and-healthcare-professionals-tutorial-real-world-data-analysis - 2025-10-03

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. Read more here.

https://www.lupop.lu.se/article/avoiding-dynastic-assortative-mating-and-population-stratification-biases-mendelian-randomization - 2025-10-03

Development and use of health outcome descriptors: a guideline development case study

McMaster GRADE Centre researchers developed ‘health outcome descriptors’ for standardizing descriptions of health outcomes and overcoming these problems to support the European Commission Initiative on Breast Cancer (ECIBC) Guideline Development Group (GDG). We aimed to determine which aspects of the development, content, and use of health outcome descriptors were valuable to guideline developers.

https://www.lupop.lu.se/article/development-and-use-health-outcome-descriptors-guideline-development-case-study - 2025-10-03

Facilitators for using data from a quality registry in local quality improvement work: a cross-sectional survey of the Danish Cardiac Rehabilitation Database

Objectives: To investigate use of data from a clinical quality registry for cardiac rehabilitation in Denmark, considering the extent to which data are used for local quality improvement and what facilitates the use of these data, with a particular focus on whether there are differences between frontline staff and managers. Read more here.

https://www.lupop.lu.se/article/facilitators-using-data-quality-registry-local-quality-improvement-work-cross-sectional-survey-0 - 2025-10-03

Using aggregated data from Swedish national quality registries as tools to describe health conditions of older adults with complex needs

Combining National Quality Registries (NQRs) with existing National Health Registries (NHRs) might make it possible to get a wider picture of older adults health situation. The aim was to examine the feasibility of aggregating data across different NQRs and existing NHRs to explore the possibility to investigate trajectories and patterns of disease and care, specifically for the most ill older adu

https://www.lupop.lu.se/article/using-aggregated-data-swedish-national-quality-registries-tools-describe-health-conditions-older - 2025-10-03

FORTE: Ingen utlysning av nätverksbidrag, gästforskarbidrag, tidskriftsbidrag och konferensbidrag 2020

Forte har påbörjat en översyn av ett antal mindre bidragsformer. Under 2020 sker därför ingen utlysning av nätverksbidrag, tidskriftsbidrag, konferensbidrag och gästforskarbidrag. Läs mer på https://forte.se/nyhet/ingen-utlysning-av-natverksbidrag-gastforskarbid….

https://www.lupop.lu.se/article/forte-ingen-utlysning-av-natverksbidrag-gastforskarbidrag-tidskriftsbidrag-och-konferensbidrag-2020 - 2025-10-03

Corona akut-utlysning 2020

Med anledning av coronakrisen deltar Forte i Formas akututlysning för 2020. Utlysningen ska ge möjlighet att samla in forskningsmaterial av akut karaktär för att säkerställa framtida tillgänglighet för forskning. Forskare inom Fortes områden kan ansöka om medel för datainsamling med koppling till coronapandemin. Läs mer på https://forte.se/utlysning/akututlysning-2020.

https://www.lupop.lu.se/article/corona-akut-utlysning-2020 - 2025-10-03