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Higher dose cohort initiated after positive early safety evaluation in Parkinson's therapy. After a positive initial safety evaluation, the pioneering STEM-PD clinical trial has advanced to higher dose testing. STEM-PD is a first-in-human clinical trial testing a new investigational therapy for Parkinson’s disease aimed at replacing the dopamine cells lost to the disease with healthy ones derived

https://www.stemcellcenter.lu.se/article/update-stem-pd-clinical-trial-stem-cell-based-transplant-parkinsons-disease - 2025-10-27

Researchers at Lund University and DTU in Copenhagen have discovered enzymes in the colon that, when mixed with red blood cells, can cut away parts of the carbohydrates that separate our ABO blood groups from each other. The method brings us closer to the dream of a universal blood for everyone. It has long been known that blood from different individuals cannot be mixed randomly without the risk

https://www.stemcellcenter.lu.se/article/enzymes-intestinal-bacteria-opens-universal-blood - 2025-10-27

At Lund University’s Biomedical Centre, the FACS Core Facility hums with activity, hosting a range of machines ready to support scientific research. Now, the facility welcomes its latest addition: a high-tech spectral flow cytometry instrument coupled with image-based sorting capacity. Scientists from various disciplines are lining up to use this new tool, which promises to make cell research fast

https://www.stemcellcenter.lu.se/article/new-era-flow-cytometry-arrives-facs-core-facility - 2025-10-27

Researchers at Lund University have discovered how a hidden piece of DNA, known as a transposable element, disrupts normal gene function in a disease called X-Linked Dystonia-Parkinsonism (XDP). Published in Nature Structural and Molecular Biology, their findings uncover the epigenetic processes that lead to changes in gene expression linked to XDP, offering new insights into how this rare genetic

https://www.stemcellcenter.lu.se/article/how-hidden-genetic-elements-trigger-rare-disorder - 2025-10-27

There comes a point in every researcher's work when the data goes beyond numbers and charts, transforming into something visually captivating. The annual Image Competition held by the Lund Stem Cell Center celebrates these moments, showcasing images that turn scientific discoveries and experiments into works of art. Today, we are pleased to present the images from our 2024 Image Competition. Combi

https://www.stemcellcenter.lu.se/article/where-science-meets-art-inside-lund-stem-cell-centers-2024-image-competition - 2025-10-27

Filipe Pereira and his research team have discovered a recipe on how to reprogram cancer cells into antigen-presenting dendritic cells, essential for initiating and enhancing anti-tumour immunity. This approach provides a promising strategy for cancer treatment. The goal of the now awarded project is to engineer the "vehicle" to deliver the instruction converting the cells, utilizing RNA vectors f

https://www.stemcellcenter.lu.se/article/professor-filipe-pereira-awarded-erc-proof-concept-grant - 2025-10-27

Neuroblastoma is a tumor disease that primarily affects young children. The survival rate is the lowest of all childhood cancers. Now, a research team at Lund University has discovered that a specific gene is associated with a poorer prognosis. The study is published in the journal Science Advances. Every year, about twenty children in Sweden are diagnosed with neuroblastoma. Neuroblastoma is a ca

https://www.stemcellcenter.lu.se/article/gene-controls-prognosis-neuroblastoma - 2025-10-27

Dr. Olle Lindvall, recently awarded a jubilee doctorate from Lund University, has spent more than fifty years studying the brain and how to repair it. His work has turned ideas that once seemed like science fiction into scientific reality. Looking back on his journey from curious medical student to clinical neuroscientist, he talks about his accomplishments, the challenges he faced, and gives advi

https://www.stemcellcenter.lu.se/article/what-fuels-lifetime-scientific-discovery-olle-lindvall-reflects-his-journey-neuroscience - 2025-10-27

Researchers at Lund University are developing a new type of gene therapy that reprograms cancer cells within tumors into immune cells that can help the immune system fight cancer. Their approach, now published in the journal Science, could lead to more effective treatments for hard-to-treat cancers. Cancer is known for its ability to hide from the immune system, making it tough to fight. But what

https://www.stemcellcenter.lu.se/article/researchers-reprogram-tumor-cells-cancer-fighting-immune-cells-living-beings - 2025-10-27

By describing his research as a battle between good and evil and likening himself to a hacker who attacks cancer cells to make them kind, PhD student Luís Oliveira took home the win in this year's Research Grand Prix. It is a competition in presentation technique for researchers, and it was held in front of an audience of almost 400 students at Helsingborg's Stadsteater on 1 October. His presentat

https://www.stemcellcenter.lu.se/article/research-reprogramming-cancer-cells-won-presentation-competition-research-grand-prix - 2025-10-27

Olga Zimmermannova from the Pereira Research Group has been awarded the 2024 Article of the Year Award. She received the award for her research on reprogramming cancer cells into dendritic cells of the immune system as a potential cancer therapy. The Lund Stem Cell Center Article of the Year Award, presented annually since 2017, highlights exceptional research conducted at the Center that contribu

https://www.stemcellcenter.lu.se/article/lund-stem-cell-centers-2024-article-year-goes-olga-zimmermannova - 2025-10-27

Two researchers at Lund Stem Cell Center receive grants, 61 million, for research into immunological long-term memory and reprogramming of tumor cells. The research should lead to more effective vaccination strategies and immunotherapies. The Knut and Alice Wallenberg Foundation has granted SEK 835 million to 30 different projects in medicine, natural science and technology that are deemed to have

https://www.stemcellcenter.lu.se/article/yuan-and-pereira-receive-grants-wallenberg-foundation - 2025-10-27

Joan Yuan, researcher and associate professor in immunology, receives the Eric K. Fernström prize for younger, particularly promising and successful researchers at Lund University in 2024. Her research is about how the immune system is formed and how it affects us throughout life. Award justification: "For her decisive discoveries that have changed our understanding of hematopoiesis and the immune

https://www.stemcellcenter.lu.se/article/eric-k-fernstrom-award-young-successful-researchers-goes-joan-yuan - 2025-10-27

Researchers at Lund University’s Lund Stem Cell Center have made a new discovery about how the human genome protects itself from disruption during critical stages of life. Their study, recently published in Nature Communications, reveals how two key defense mechanisms—DNA methylation and the HUSH complex—work together to safeguard genomic stability. The human genome contains large stretches of rep

https://www.stemcellcenter.lu.se/article/new-research-gives-insights-human-genomes-defence-mechanisms - 2025-10-27

Researchers at Lund University’s Lund Stem Cell Center have made new strides in understanding why some patients with chronic myeloid leukemia respond better to treatment than others. Their study, recently published in eLife, suggests that the amount of healthy blood stem cells at diagnosis could be a key factor in predicting how well patients will respond to standard therapies. Chronic myeloid leu

https://www.stemcellcenter.lu.se/article/new-findings-reveal-why-some-chronic-myeloid-leukemia-patients-respond-better-treatment - 2025-10-27

On October 18, 2024, two researchers from Lund Stem Cell Center were awarded funding from the Mats Paulsson Foundation for Research, Innovation, and Societal Development. A total of 16 million SEK was distributed to life science projects across Skåne, with a focus on advanced therapy medicinal products (ATMPs). This year, the foundation, which supports research with "high innovation potential and

https://www.stemcellcenter.lu.se/article/lund-stem-cell-center-researchers-secure-grants-innovative-stem-cell-projects - 2025-10-27

Malin Parmar, professor of cellular neuroscience, along with three researchers in Italy and Denmark, has been awarded the prestigious ERC Synergy Grant worth EUR 10 million. The four researchers aim to develop custom-made neurons from stem cells for cell therapies to treat Parkinson’s or Huntington’s disease. Congratulations!“Thank you, it feels really fun and exciting for many reasons! One reason

https://www.stemcellcenter.lu.se/article/erc-synergy-grant-awarded-development-custom-made-stem-cell-therapies - 2025-10-27

The Lund Stem Cell Center at Lund University has relaunched its Professional Development Program (PDP), which provides PhD students support beyond research, equipping them with the personal and professional skills essential for long-term career success. While most doctoral programs focus on scientific expertise, the PDP broadens that approach by equipping students with skills for career growth, se

https://www.stemcellcenter.lu.se/article/lund-stem-cell-center-relaunches-professional-development-program-phd-success - 2025-10-27

Jenny Hansson, associate professor at Lund University, has been awarded an 11 million SEK grant from the Swedish Society for Medical Research (SSMF). This five-year SSMF Consolidator Grant will support her research into acute leukemia, focusing on uncovering the biological differences between childhood and adult forms of the disease. Why does childhood leukemia behave so differently from adult leu

https://www.stemcellcenter.lu.se/article/jenny-hansson-awarded-11-million-sek-swedish-society-medical-research - 2025-10-27

After 20 years of research on gene therapy and the rare blood disease, Diamond–Blackfan Anemia, DBA, researcher Johan Flygare had reached a point where he and his colleagues had done everything they could in the lab. Even though they had proof of concept their gene therapy would work, engaging companies had been difficult. Then, in 2021, he received an e-mail. The message came from American entrep

https://www.stemcellcenter.lu.se/article/science-start-developing-gene-therapy-rare-blood-disorder - 2025-10-27