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I en studie ledd från Lunds universitet kan forskarna för första gången visa att traumatiska hjärnskador aktiverar vilande endogena retrovirus som under årmiljonernas gång infogats i människans DNA. Att dessa aktiveras kan vara drivande för att starta en inflammation som förvärrar hjärnskadan. Studien är publicerad i Cell Reports. Läs artikeln här: Single-cell transcriptomics of human traumatic br

https://www.molecular-neurogenetics.lu.se/article/svart-hjarntrauma-aktiverar-vilande-kroppsegna-retrovirus-i-hjarnan - 2025-10-01

"Tack vare ny teknik har Storbritannien precis godkänt en behandling som botar två genetiska sjukdomar. Nu ligger vägen öppen för att behandla andra sorters lidande." "– Vi kommer att kunna utveckla botande behandlingar för många ovanliga sjukdomar som inte går att bota i dag, säger Johan Jakobsson."För att läsa artikeln, vänligen gå till Dagens Nyheter: https://www.dn.se/varlden/nya-behandlingar-

https://www.molecular-neurogenetics.lu.se/article/dagens-nyheter-nya-behandlingar-sjukdomar-som-tidigare-var-omojliga-att-bota - 2025-10-01

Today we congratulate Dr. Raquel Garza on defending her thesis! Dr. Raquel Garza's thesis "Transposable Elements in the Healthy and Diseased Human Brain" is available online.For an interview with Dr. Raquel Garza please visit Multipark's website.

https://www.molecular-neurogenetics.lu.se/article/congratulations-dr-raquel-garza - 2025-10-01

Researchers from the Jakobsson Group at Lund University have discovered how a hidden piece of DNA, known as a transposable element, disrupts normal gene function in a disease called X-Linked Dystonia-Parkinsonism (XDP). Published in Nature Structural and Molecular Biology, their findings uncover the epigenetic processes that lead to changes in gene expression linked to XDP, offering new insights i

https://www.molecular-neurogenetics.lu.se/article/how-hidden-genetic-elements-trigger-rare-neurodegenerative-disorder - 2025-10-01

Interested in how we work with cutting out bad genes and pasting in new, healthy ones? In this case, you might find the below article on new gene techniques and our research very intersting! På svenska: Är du nyfiken på hur vi arbetar med att klippa ut de dåliga generna och klistra in nya friska gener? Då kan den följande artikeln om ny genteknik och vår forskning vara mycket intressant!På svenska

https://www.molecular-neurogenetics.lu.se/article/om-att-klippa-och-klistra-i-dna-how-cut-and-paste-gene-sequence - 2025-10-01

Läs här om vår senaste publikation som presenterar en direkt länk mellan Huntingtons sjukdom och en grundläggande process som kallas autofagi.       Publikation: Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation  

https://www.molecular-neurogenetics.lu.se/article/nya-ron-om-huntingtons-sjukdom-publiceras - 2025-10-01

Interested in progress on large-scale production of living brain cells? Are you interested in progress on large-scale production of living brain cells? You can find out more in our latest paper REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.  

https://www.molecular-neurogenetics.lu.se/article/new-paper-large-scale-production-living-brain-cells - 2025-10-01

New publication! Please click here to read about our latest publication TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.Also, please click here to go to a short presentation of this research in Science: Science

https://www.molecular-neurogenetics.lu.se/article/viruses-genome-are-important-our-brain - 2025-10-01

We're very happy to announce that our former PhD student Rebecca Petri has received the Best Thesis Award 2017 from the Neurobiology Section of Lund University. Well done, Rebecca! 

https://www.molecular-neurogenetics.lu.se/article/best-thesis-award-2017-goes-rebecca-petri - 2025-10-01

2019-04-09. Today we celebrated the official nailing of Per Ludvik Brattås' thesis entiteled "The Epigenetic Impact of Transposable Elements in Human Brain Development". Per's defence will take place on April 26th at 13 o'clock at the Segerfalk lecture hall (BMC, A10) - you are most welcom to join us! 

https://www.molecular-neurogenetics.lu.se/article/ludviks-thesis-officially-nailed - 2025-10-01

We are very happy to announce that Per Ludvik Brattås has successfully defended his thesis entitled "The Epigenetic Impact of Transposable Elements in Human Brain Development". Congratulations, Dr. Brattås!

https://www.molecular-neurogenetics.lu.se/article/congratulations-dr-brattas - 2025-10-01

We're happy to present our most recent publication "Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors" published on July 18th. Our study sheds light on the darker parts of our genetic heritage. To find out more please click on the below link.Lund University's press release Nature Communications: Activation of neuronal genes via LINE-1 elemen

https://www.molecular-neurogenetics.lu.se/article/new-publication-nature-communications - 2025-10-01

Läs den spännande debatten om den nya gentekniken Crispr, skriven av forskare från gruppen Crispr ideas vid Pufendorfinstitutet, Lunds universitet, på SvD Debatt. SvD Debatt: ”Vi måste ta ställning till nya gentekniken” Aftonbladet: "Den nya gensaxen måste diskuteras"   Om debattörerna: Karin Broberg, professor i arbets- och miljömedicin Ingrid Dunér, doktorand i idéhistoria Kristofer Hansson, doc

https://www.molecular-neurogenetics.lu.se/article/pa-svenska-nya-gentekniken-kraver-en-bred-debatt - 2025-10-01

Today we celebrated official nailing of Daniela Grassi's thesis "Development and Applications of in vitro Models to Study Human Brain Evolution and Disease". The defence will take place on Thursday April 23rd at 9.00 o'clock and it will be made availably digitally for you to join!

https://www.molecular-neurogenetics.lu.se/article/nailing-completed - 2025-10-01

Daniela Grassi will be defending her thesis on Thursday 23rd of April 2020. Here, Daniela tells us about her research in the Molecular Neurogenetics group. Please click here for full article: https://www.stemcellcenter.lu.se/article/thesis-defence-interview-daniela-grassi 

https://www.molecular-neurogenetics.lu.se/article/thesis-defence-interview-daniela-grassi - 2025-10-01

Interested in autophagy or Huntington disease? Please click here to go to our newest publication Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease and to more information on our work in the field.

https://www.molecular-neurogenetics.lu.se/article/new-article-autophagy-and-treatment-huntington-disease - 2025-10-01

Read here about Christopher Douse who joined our group at the beginning of 2020 and works on developing a research programme on newly-discovered guardians of the human genome. For article please click on the following link: https://www.stemcellcenter.lu.se

https://www.molecular-neurogenetics.lu.se/article/meet-christopher-douse - 2025-10-01

Read about how the CRISPR facility at Lund Stem Cell Center can help you with your experiments CRISPR is a simple yet powerful Nobel Prize winning technology that allows sequence specific editing and manipulation of DNA sequences. The CRISPR facility at Lund Stem Cell Center is here to help you with your projects using this technology. To read more please go to: https://www.stemcellcenter.lu.se/ar

https://www.molecular-neurogenetics.lu.se/article/lund-crispr-facility-here-help - 2025-10-01

Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute to brain disorders later in life. To read the article, please go to: https://www.stemcellcenter.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation

https://www.molecular-neurogenetics.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation - 2025-10-01

Har du koll på vad stamceller gör och kan? Testa vad du vet med Sydsvenskans quiz ”Svara Lund”: Vad kan du om stamceller? För att komma till Sydsvenskans quiz klicka här. frågor.pdf   rätta svar.pdf

https://www.molecular-neurogenetics.lu.se/article/sydsvenskan-quiz-svara-lund-vad-kan-du-om-stamceller - 2025-10-01