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Importance: Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. Objective: To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Design, Setting, and Participants: Individual-level analysis including data on cardiovascular
Berlin is a major tourist destination, a world city with a dramatic history. Many shelf meters have been written about it, not least combinations of travel guide and history book. The latest contribution of this kind is John Kampfner’s in Search of Berlin: The Story of a Reinvented City (London: Atlantic Books 2023, 400 pages). Kampfner is a British author, journalist and documentary maker with a
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polym
BACKGROUND: Each year, more than 1.5 million people in Europe have a stroke, and many experience disabilities leading to activity and participation restrictions. Home-based rehabilitation is the recommended approach for stroke rehabilitation, in line with the international shift to integrated care. Despite this, rehabilitation often focuses on the person's physical functions, not the whole life si
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10−8) and confirmed previously reported associations
The first search for nonresonant Bc+→π+μ+μ- decays is reported. The analysis uses proton–proton collision data collected with the LHCb detector between 2011 and 2018, corresponding to an integrated luminosity of 9fb-1. No evidence for an excess of signal events over background is observed and an upper limit is set on the branching fraction ratio B(Bc+→π+μ+μ-)/B(Bc+→J/ψπ+)
A measurement of CP-violating observables in B± → D*K± and B± → D*π± decays is made where the photon or neutral pion from the D*→ Dγ or D*→ Dπ0 decay is not reconstructed. The D meson is reconstructed in the self-conjugate decay modes, D → KS0π+π− or D → KS0K+K−. The distribution of signal yields in the D decay phase space is analysed in a model-independent way. The measurement uses a data sample
Human rights concerns in relation to the impacts brought forth by artificial intelligence (‘AI’) have revolved around examining how it affects specific rights, such as the right to privacy, non-discrimination and freedom of expression. However, this article argues that the effects go deeper, potentially challenging the foundational assumptions of key concepts and normative justifications of the hu
In the last decade, businesses have played an increasingly significant role in promoting stability, democracy, and human rights, particularly concerning the United Nations Sustainable Development Goals, which emphasize peace, justice, and strong institutions. Consequently, there has been a greater focus on corporate social responsibility and corporate citizenship. Research has explored business mo
A search for CP violation in D0→KS0K+π− and D0→KS0K−π+ decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb−1 collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of s = 13 T
The production of ψ(2S) mesons in proton-lead collisions at a centre-of-mass energy per nucleon pair of sNN = 8.16 TeV is studied with the LHCb detector using data corresponding to an integrated luminosity of 34 nb−1. The prompt and nonprompt ψ(2S) production cross-sections and the ratio of the ψ(2S) to J/ψ cross-section are measured as a function of the meson transverse momentum and rapidity in t
I antologin Antirasismer och antirasister: Realistiska utopier, spänningar och vardagserfarenheter utforskar 24 forskare hur motståndet mot olika former av rasism bedrivs och förkroppsligas bedrivs bland grupper av människor som på en mängd sätt, ofta motsägelsefullt, sällan framgångsrikt, men alltid envist och framåtblickande drömmer bortom rasismer. Antologin illustrerar antirasismens bredd, men
OBJECTIVE: To assess the effect of lateral episiotomy, compared with no episiotomy, on obstetric anal sphincter injury in nulliparous women requiring vacuum extraction.DESIGN: A multicentre, open label, randomised controlled trial.SETTING: Eight hospitals in Sweden, 2017-23.PARTICIPANTS: 717 nulliparous women with a single live fetus of 34 gestational weeks or more, requiring vacuum extraction wer
This paper examines the responses of Indigenous nations and European companies to new trading opportunities: the Cree nations with the Hudson's Bay Company (HBC) and the Khoe nations with the Dutch East India Company [Verenigde Oostindische Compagnie (VOC)]. This case study is important because of the disparate outcomes. Within a few decades the Cree standard of living had increased, while Khoe na
This chapter will deal with the advances and the innovative paradigms leading to reengineering the preservation of the myocardium and the potential of new upcoming reconditioning strategies to reduce BDD organ shortage and move toward DCD donation.
Die Folgen des Klimawandels für die Gesundheit sind bereits heute spürbar und als zunehmende Bedrohung für die Gesundheit in Österreich einzustufen. Die stärksten Gesundheitsfolgen mit breiter Wirkung sind durch Hitze zu erwarten. Veränderungen in Ökosystemen begünstigen zudem das Auftreten von Pollenallergien und durch Vektoren übertragene Infektionskrankheiten. Mit vermehrten Gesundheitsfolgen i
In this paper, we report the results from an experimental reproductive ethics study exploring questions about reproduction and parenthood. The main finding in our study is that, while we may assume that everyone understands these concepts and their relationship in the same way, this assumption may be unwarranted. For example, we may assume that if ‘x is y’s father’, it follows that ‘y is x’s child
