Comparing α-Synuclein Fibrils Formed in the Absence and Presence of a Model Lipid Membrane : A Small and Wide-Angle X-Ray Scattering Study
Amyloid fibrils are associated with a number of different neurodegenerative diseases. Detailed knowledge of the fibril structure will be of importance in the search of therapy and may guide experiments to understand amyloid formation. In this paper we investigate the morphology of α-synuclein amyloid fibrils, associated with Parkinson’s disease, formed under different conditions. In particular, we