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Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac

Tourism makes substantial contributions to the Anthropocene. However, the Anthropocene is highly uneven over space and time reflecting the uneven processes of capital accumulation. As a result, the Anthropocene, and tourism's role within it, is best understood as a system of power, profit and re/production in the web of life, what is referred to as the capitalocene. In other words, it is the relat

Background Does the genetic aptitude for educational attainment (GAEA) moderate the genetic risk for alcohol use disorder (AUD) and drug use disorder (DUD)? Methods In the native Swedish population, born 1960-1980 and followed through 2017 (n = 1 862 435), the family genetic risk score (FGRS) for AUD and DUD and GAEA were calculated from, respectively, the educational attainment and risk for AUD a

Purpose: The authors intend to assess the village health sanitation and nutrition committees (VHSNC) on six parameters, including their formation, composition, meeting frequencies, activities, supervisory mechanisms and funds receipt and expenditures across nine districts of the three states of India. Design/methodology/approach: The cross-sectional study, conducted in the states of Uttar Pradesh

Adjuvant treatment of nonmetastatic high-risk renal cell carcinoma is an unmet medical need. In the past, several tyrosine kinase inhibitor trials have failed to demonstrate an improvement of disease-free survival (DFS) in this setting. Only one trial (S-TRAC) provided evidence for improved DFS with sunitinib but without an overall survival (OS) signal. Keynote-564 is the first trial of an immune

Like many other West European countries during the early modern period, Swedish society was structured by a variety of hierarchies and, in this context, the principle of filial deference, or the obedience and recognition children–young or adult–were expected to show their parents, was more or less absolute. These ideas of family hierarchy also influenced marriage laws and the formal rules of who w

Recently, challenge-oriented innovation policy has become increasingly popular in political and scientific discussions. However, the extent to which such a challenge-based thinking has entered regional policy making is relatively unclear. This paper examines the scope of the regional level in promoting challenge-based innovation, focusing on the recent renewable energy innovation policy in Schlesw

The 400-km long coast of the Bight of Benin, formed by sand barriers and lagoons, is bordered to the east by the Niger River Delta and to the west by the Volta River Delta and is characterized by several coastal infrastructures, of which the most important are the deep water harbors of Lomé, Cotonou, and Lagos. In this study, an enhanced version of the CASCADE coastal evolution model was implement

Biografisk artikel om skådespelerskan och revyprimadonnan Nita Hårleman (1891-1961).

Nanocomposites, formed by incorporating nanoparticles into a matrix of standard materials, are increasing on the market. Little focus has been directed towards safe disposal and recycling of these new materials even though the disposal has been identified as a phase of the products' life cycle with a high risk of uncontrolled emissions of nanomaterials. In this study, we investigate if the carbon

The ultrafast structural dynamics of water following inner-shell ionization is a crucial issue in high-energy radiation chemistry. We have exposed isolated water molecules to a short X-ray pulse from a free-electron laser and detected momenta of all produced ions in coincidence. By combining experimental results and theoretical modeling, we can image dissociation dynamics of individual molecules i

This chapter examines the increasing potential of international criminal law to advance hegemonic claims over the meaning of concepts relevant beyond its own field. By building on the Gramscian conceptualisation of hegemony and the role of law therein, I suggest that international criminal law advances a certain understanding of violence, that obscures and normalises types of violence that are bey

A new, and only the third known species of the Neotropical montane genus Oressinoma Doubleday is described—O. sorina n. sp., from the Andes of central Peru. It is distinguishable immediately from the other two congeners by the shape of the hindwing underside submarginal orange band, and by the male genitalia. The systematics of Oressinoma are reviewed. A preliminary analysis is carried out based o

Online measurements of the raw gas composition, including tars and water, during biomass gasification provide valuable information in fundamental investigations and for process control. Mainly consisting of hydrocarbons, tars can, in principle, be measured using Fourier transform infrared (FT-IR) spectroscopy. However, an instrument subjected to raw gas runs the risk of condensation of tars on opt

Pre-understanding – our presuppositions of reality – underlies all research. Many researchers probably also draw productively on their pre-understanding in their studies. However, very few rationales and methodological resources exist for how researchers can enrich their research by mobilizing their pre-understanding more actively and systematically. We elaborate and propose a framework for how re

Gluten proteins are intrinsically disordered proteins that form extensive aggregated networks in wheat seeds, where they are stored as a nutrient source for the embryo. A modelling approach involving computational biology with Monte-Carlo algorithms and wet laboratory studies, including HPLC analysis, was applied to unravel the aggregational and hydrogelforming properties of the gluten proteins. T

Spatially and temporally resolved in situ measurements of HCN in a steady state tube furnace have been performed using mid-infrared polarization spectroscopy (IRPS). Such measurements are important for the understanding of the detailed HCN chemistry, including pyrolysis, gas phase production, and gas phase consumption. The measurements presented here are in agreement with existing models for HCN c

Gut-associated lymphoid tissues (GALT) serve as key priming sites for intestinal adaptive immune responses. Most of our understanding of GALT function and development arises from studies in mice. However, the diversity, structure and cellular composition of GALT differs markedly between mammalian species and the developmental window in which distinct GALT structures develop in large mammals remain