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Renal cell carcinomas (RCCs) are a group of tumours that arise from the nephron within the kidney. They are characterised by an indolent growth pattern and do not display overt clinical symptoms in patients with early to locally advanced tumours. Furthermore, the global average age of a RCC patient at diagnosis is 75 and they usually present with co-morbidities that may render invasive surgical/bi
Sedan 2014 har polismyndigheten arbetat med att kartlägga diverse områden och hur de påverkas av den lokala brottsligheten. De områden som är mest drabbade kallar de för utsatta områden.Since 2014, the police authority has worked to map various areas and how they are affected by local crime. The areas that are most affected are called vulnerable areas.
Ungefär hälften av alla cancerpatienter genomgår strålbehandling, antingen som en enskild behandling eller i kombination med kirurgi och/eller medicinsk behandling. Vid strålbehandling används högenergetisk joniserande strålning för att bekämpa cancerceller. Strålningen orsakar skador på tumörcellernas DNA, men kan även skada friska celler. För att uppnå bästa möjliga behandlingseffekt med minsta FLASH radiotherapy (FLASH-RT) is a promising new approach to radiotherapy that has the potential to transform the field. By administering radiation at ultra-high dose rates (UHDR) on a millisecond timescale, FLASH-RT may increase normal tissue tolerance compared to conventional radiotherapy while maintaining the anti-tumoral effect. However, the short treatment times present unique physical and te
The subcellular localization of proteins is closely related to their functions. In this work, we propose a novel approach based on localization motifs to improve the accuracy of predicting subcellular localization of Gram-positive bacterial proteins. Our approach performed well on a five-fold cross validation with an overall success rate of 89.5%. Besides, the overall success rate of an independen
Motivation: Turns are a critical element of the structure of a protein; turns play a crucial role in loops, folds, and interactions. Current prediction methods are well developed for the prediction of individual turn types, including α-turn, β-turn, and γ-turn, etc. However, for further protein structure and function prediction it is necessary to develop a uniform model that can accurately predict
Motivation: The precise prediction of protein domains, which are the structural, functional and evolutionary units of proteins, has been a research focus in recent years. Although many methods have been presented for predicting protein domains and boundaries, the accuracy of predictions could be improved. Results: In this study we present a novel approach, DomHR, which is an accurate predictor of
A novel metabolomic method based on gas chromatography-mass spectrometry was applied to investigate serum metabolites in response to dietary Gln supplementation in piglets. Sixteen, 21-d-old pigs were weaned and assigned randomly to 2 isonitrogenous diets: 1) Gln diet, which contained 1% L-Gln (as-fed basis), and 2) control diet, which contained LAla to make this diet isonitrogenous with the Gln d
Recension av Lutz Gschwinds avhandling "Migrationand social protection inEuropean welfare states:cui bono?" från 2021.
The feasibility of different options to reduce the risks of climate change has engaged scholars for decades. Yet there is no agreement on how to define and assess feasibility. We define feasible as “do-able under realistic assumptions.” A sound feasibility assessment is based on causal reasoning; enables comparison of feasibility across climate options, contexts, and implementation levels; and ref
The 1952 General Plan for Stockholm is often seen as Sweden’s most important postwar planning document, sketching the outlines of the social-democratic urban region. In the words of city planning director Sven Markelius, it showcased ”the possibilities for building a townscape, or a milieu, with all its components that satisfy the demands we have on urban life today”. This plan has since acquired The 1952 General Plan for Stockholm is often seen as Sweden’s most important postwar planning document, sketching the outlines of the social-democratic urban region. In the words of city planning director Sven Markelius, it showcased ”the possibilities for building a townscape, or a milieu, with all its components that satisfy the demands we have on urban life today”. This plan has since acquired
BackgroundRectal washout (RW) is performed to eliminate intraluminal cancer cells and thereby reducing the risk of local recurrence (LR). The overall aim of this thesis was to investigate the importance of RW in rectal cancer surgery.MethodPaper I: Survey of the current practice of RW among Swedish colorectal units.Paper II: The association between RW and 30-day postoperative complications after a
This article aims to explore how policy translation and institutional legacies have shaped South Korean parental leave policies between 1995 and 2021. It draws on a document analysis of central political documents and interviews with a number of key policy actors in South Korea. The findings show that reforms of parental leave policies were implemented according to four major rationales: maternityThis article aims to explore how policy translation and institutional legacies have shaped South Korean parental leave policies between 1995 and 2021. It draws on a document analysis of central political documents and interviews with a number of key policy actors in South Korea. The findings show that reforms of parental leave policies were implemented according to four major rationales: maternity
Care of older persons in community and primary care differs substantially between European countries, but most countries pursue the concept of “ageing in place”, meaning that most older people do not live in institutions. More and more older people are living alone. Relatives still play an important role in the care of older people, but it differs substantially within Europe, and will probably rem
Nanowires are explored as basic components for a large range of electronic devices. The nanowire format offersseveral benefits, including reduced material consumption and increased potential for combining materials to formnew novel heterostructures. Several factors, such as mechanical stress from contacting or a lattice mismatch in aheterostructure, can strain and change the lattice tilt. The stra
BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm
BackgroundLoss to follow-up (LTFU) from tuberculosis (TB) treatment and care is a major public health problem as patients can be infectious and also may develop a multi-drug resistant TB (MDR-TB). The study aimed to assess whether LTFU differs by the distance TB patients travelled to receive care from the nearest health facility.MethodsA total of 402 patient cards of TB patients who received care
