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Objectives We aimed to describe clinical and diagnostic characteristics of primary care patients with heart failure and physicians’ adherence to guideline-directed medical therapy (GDMT) for treating chronic heart failure. Design Cross-sectional study based on baseline data from the prospective primary care-based study Heart failure in Southern Sweden (HISS). Setting Patients with heart failure we

Betulin is a natural pentacyclic triterpene, and is contained in birch tree, especially its outer bark. Betulin can be used as a hydrophobic building block for production of biobased surfactants. This invention is related to amphiphilic betulin derivatives, and their efficient production method. And resulting materials can be used as biobased surfactants.

The present invention relates to an amphipathic compound, a preparation method therefor, and a surfactant composition comprising same and, specifically, to a compound selected from the group consisting of steviol monoglycoside-acid, steviol monoglycoside-ester, and steviol monoglycoside-amide, a preparation method therefor, and a surfactant composition comprising at least one of these compounds.

A search for R-parity-violating supersymmetry in final states with high jet multiplicity is presented. The search uses 140 fb−1 of proton-proton collision data at s = 13 TeV collected by the ATLAS experiment during Run 2 of the Large Hadron Collider. The results are interpreted in the context of R-parity-violating supersymmetry models that feature prompt gluino-pair production decaying directly to

The integration of machine learning (ML) into software operations (MLOps) has significantly increased the demand for data to train and test models, making data sharing and reuse essential to mitigate the high costs of data collection and preprocessing. This study aims to advance the understanding of data sharing within an MLOps context by examining the establishment and governance of a data ecosys

Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se

Measurements of inclusive charged-particle jet production in pp and p-Pb collisions at center-of-mass energy per nucleon-nucleon collision sNN = 5.02 TeV and the corresponding nuclear modification factor RpPbchjet are presented, using data collected with the ALICE detector at the LHC. Jets are reconstructed in the central rapidity region |ηjet| < 0.5 from charged particles using the anti-kT algori

Acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer. Bone marrow (BM) fibrosis in ALL has been associated with adverse outcomes; however, little is known about the mechanisms that cause fibrosis in ALL. Therefore, we established a novel and advanced analysis method by combining multicolor immunofluorescence (IF) staining with in situ RNA expression analysis (RNAscope) to inve

Background: Alcohol intake increases recurrence of atrial fibrillation (AF), but its relationship with cardiovascular outcomes is less well characterized. We aimed to study the association between different levels of alcohol intake and cardiovascular outcomes in a global cohort of patients with AF. Methods: This is a cross-sectional analysis of the RE-LY AF registry, including 15,400 patients with

Precise patient positioning and daily anatomical verification are crucial in external beam radiotherapy to ensure accurate dose delivery and minimize harm to healthy tissues. However, Current image-guided radiotherapy techniques struggle to balance high-quality volumetric anatomical visualization and rapid low-dose imaging. Addressing this, reconstructing volumetric images from ultra-sparse X-ray

To date, the use of CRISPR/Cas9 technology in ecological-model species for validating genotype to phenotype connections has focused primarily on visual phenotypes using G0 mutations, coupled with analyses of resulting mosaic phenotypes. However, studies of physiological phenotypes necessitate germline mutations in order to assess non-visible phenotypic effects, and thus, dedicated efforts to devel

Quantifying solute transport across epithelial cell layers grown on transwell inserts is a common approach in early-stage drug development to estimate pharmacokinetic properties such as absorption and bioavailability. To increase throughput and reduce variability, these assays are increasingly automated, including the use of robotic or microfluidic systems for time-resolved sampling. However, both

Ethylene carbonate (EC) is the archetype solvent in Li-ion batteries. Still, questions remain regarding the numerous possible reaction pathways of EC. Although the reaction pathway involving direct EC reduction and SEI formation is most commonly discussed, EC ring-opening is often observed, but seldomly addressed, especially with respect to SEI formation. By applying Online Electrochemical Mass Sp

Although the two active redox centers in Li-rich cathodes, including the anionic and cationic contributions, can enable Li-ion batteries to achieve outstanding specific energy, their behaviors at different current densities have not been clarified. Here, we provide a comparative study of transition metals (TMs) and oxygen redox activities by directly accessing their oxidation states in Li-rich mat

Aqueous rechargeable batteries are appealing alternatives for large-scale energy storage. Reversible cycling of high-energy aqueous batteries has been showcased using highly concentrated aqueous electrolytes, which lead to a significantly suppressed water activity and formation of a stable solid-electrolyte interphase (SEI). However, the high salt concentration inevitably raises the cost and compr

This study explores the integration of Large Language Model (LLM) and Information Retrieval (IR) components to enable filtered search over multimodal structured data. We identify core integration challenges and introduce a conceptual framework based on two paradigms: filtered retrieval and filtered re-ranking. With the focus on the latter, we employ RT-3 rank transformation to dynamically adjust t

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2

Rationale: Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and prevent complications. Midazolam is a short-acting benzodiazepine that is used in neonatal intensive care units. This is an update of a Cochrane review first published in 2003. Objectives: To assess the benefits and harms of midazolam – compared with placebo, other pharmacological interventions, and n

Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, b