Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of importance to understand the biology of drug targets, particularly the newly emerging ones. A comprehensive evaluation of these targets will benefit drug development with increased likelihood for success in clini

Noise pollution is a growing global public health concern. Among other issues, it has been linked with sleep disturbance, hearing functionality, increased blood pressure and heart disease. Individuals are increasingly using social media to express complaints and concerns about problematic noise sources. This behavior-using social media to post noise-related concerns-might help us better identify t

Quenching of vibrational excitations in resonant inelastic X-ray scattering (RIXS) spectra of liquid acetic acid is observed. At the oxygen core resonance associated with localized excitations at the O–H bond, the spectra lack the typical progression of vibrational excitations observed in RIXS spectra of comparable systems. We interpret this phenomenon as due to strong rehybridization of the unocc

Irrigation is the largest sector of human water use and an important option for increasing crop production and reducing drought impacts. However, the potential for irrigation to contribute to global crop yields remains uncertain. Here, we quantify this contribution for wheat and maize at global scale by developing a Bayesian framework integrating empirical estimates and gridded global crop models

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-

Background: Occupational therapists are generally positive towards use of measuring tools. However, such use may be problematic.Purpose: To illuminate hidden and adverse effects of using measuring tools in occupational therapy.Method: A Foucauldian inspired thematic analysis of the use of measuring tools in 13 reports of practice development projects in Denmark.Findings: Three themes were construcBackground.Occupational therapists are generally positive towards use of measuring tools. However, such use may be problematic.Purpose.To illuminate hidden and adverse effects of using measuring tools in occupational therapy.Method.A Foucauldian inspired thematic analysis of the use of measuring tools in 13 reports of practice development projects in Denmark.Findings.Three themes were constructed:

Organic carbon burial in lake sediments plays an important role in the global carbon cycle, and is heavily affected by the terrestrial organic matter input. However, few studies have focused on long-term changes in terrestrial organic matter input to lakes in response to land-use changes. The aim of this study was to assess variations in sedimentary terrestrial organic matter over the last 1000 ye

To expand our understanding of what tasks are particularly helped by UV vision and may justify the costs of focusing high-energy light onto the retina, we used an avian-vision multispectral camera to image diverse vegetated habitats in search of UV contrasts that differ markedly from visible-light contrasts. One UV contrast that stood out as very different from visible-light contrasts was that of

In this paper, a numerical study of flow, reactions and NOx emissions from a biomass boiler is presented. Detailed reaction mechanisms for the decomposition of tar species, combustion of hydrocarbons and formation of NOx are employed by adopting appropriate reaction sets from literature. The proposed mechanism is used to perform CFD simulations of a laboratory-scale biomass boiler, and temperature

This paper experimentally investigates the effect of various magnetic fields on the performance of a plate heat exchanger filled with ferrofluids. Spherical nanoparticles Fe3O4 with an average diameter of 20 nm are dispersed into DI-water to synthesize the ferrofluid. Thermal performance and flow characteristics of the ferrofluid with 0.1% particle concentration are investigated based on various a

Context: Continuous experimentation and A/B testing is an established industry practice that has been researched for more than 10 years. Our aim is to synthesize the conducted research. Objective: We wanted to find the core constituents of a framework for continuous experimentation and the solutions that are applied within the field. Finally, we were interested in the challenges and benefits repor

Climate change is identified as a major threat to wetlands. Altered hydrology and rising temperature can change the biogeochemistry and function of a wetland to the degree that some important services might be turned into disservices. This means that they will, for example, no longer provide a water purification service and adversely they may start to decompose and release nutrients to the surface

CO2-expanded liquids (CXLs) is a class of solvent systems giving relatively low viscosity in comparison to neat organic solvents. The challenge is to achieve a high overall polarity of the CXL, despite the presence of compressed liquid CO2. In this study, the relative static permittivity (εr) was measured for binary and ternary one-phase mixtures of CO2 + green solvent using an in-line microfluidi

We present results from neutron-imaging studies of slow, vacuum pyrolysis of beech, poplar and conifer wood, and pelletized biomass from room temperature up to 1000 °C. A detailed and quantitative method to extract 2D (in situ neutron radiography, NR) and 3D (ex situ neutron computed tomography, NCT) information on structural transformation and elemental hydrogen content has been developed. NCT an

Recent findings suggest that the effect of aging on recognition memory is modality-dependent, affecting memory for objects and scenes differently. However, the lifespan trajectory of memory decline in these domains remains unclear. A major challenge for assessing domain-specific trajectories is the need to utilize different types of stimuli for each domain (objects and scenes). We tested the large

Surrogate measures of safety (SMoS) can enable quick, pro-active, and detailed safety evaluations by studying near-crashes. A critical concern regarding SMoS is their validity. This study focused on the validity of two commonly used SMoS indicators—minimum time to collision and post-encroachment time—with a specific focus on bicyclist–motor vehicle interactions. The study was divided into two main

Risk and Vulnerability Assessments (RVAs) are often conducted by public sector organizations to prevent or prepare for hazards and threats. In Sweden, practitioners increasingly adopt approaches that are based on Business Continuity Management (BCM), where Business Impact Assessments (BIA) are used to gain organizational understanding, in favor of more traditional risk assessments. Both processes

Objectives: To compare the atrial fibrillatory rate (AFR) derived from a local right atrial intracardiac recording (RA-FR) and from a single-lead surface electrocardiogram (ECG) during atrial fibrillation (AF) and to evaluate the correlation with transvenous electrical cardioversion (TVEC) threshold (in Joules), number of shocks and cardioversion success rate in horses. Animals: ECGs and clinical

The Dachstein platform was an extensive carbonate platform developed on the westernmost shelf of the Neotethys during the Late Triassic, now preserved in various tectonic units disrupted during the Alpine orogeny. Despite being the focus of a multitude of sedimentological, paleontological and other studies, the demise of this platform remains controversial, with contrasting views on the timing and