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Gender assignment in six North Scandinavian languages : Patterns of variation and change
This study addresses gender assignment in six North Scandinavian varieties with a three-gender system: Old Norse, Norwegian (Nynorsk), Old Swedish, Nysvenska, Jamtlandic, and Elfdalian. Focusing on gender variation and change, we investigate the role of various factors in gender change. Using the contemporary Swedish varieties Jamtlandic and Elfdalian as a basis, we compare gender assignment in ot
The causality of borrowing : Lexical loans in Eurasian languages
All languages borrow words from other languages. Some languages are more prone to borrowing, while others borrow less, and different domains of the vocabulary are unequally susceptible to borrowing. Languages typically borrow words when a new concept is introduced, but languages may also borrow a new word for an already existing concept. Linguists describe two causalities for borrowing: need, i.e.
Planning for Ecosystem Services in Cities
Reconstructing the Evolution of Indo-European Grammar
This study uses phylogenetic methods adopted from computational biology in order to reconstruct features of Proto-Indo-European morphosyntax. We estimate the probability of the presence of typological features in Proto-Indo-European on the assumption that these features change according to a stochastic process governed by evolutionary transition rates between them. We compare these probabilities t
Evolutionary dynamics of Indo-European alignment patterns
This paper employs phylogenetic modeling to reconstruct the alignment system of Indo-European. We use a data set of categorical morphosyntactic features, which take states such as ‘nominative-accusative’, ‘active-stative’, or ‘ergative’. We analyze these characters with a standard Bayesian comparative phylogenetic method, inferring transition rates between character states on the basis of a phylog
Genome-wide association study of cerebral small vessel disease reveals established and novel loci
Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management. Combined genome-wide association study (GWAS) of these two correlated diseases may improve statistical power to detect novel genetic factors for cerebral small vessel disease, elucidating unde
Importance of potentially inappropriate medications, number of chronic conditions and medications for the risk of hospitalisation in elderly in Sweden : A case-control study
Objectives This study aimed to investigate the importance of potentially inappropriate medications, number of medications and chronic conditions for the risk of hospitalisation among an elderly population. Design This is a case-control study. Setting Population-based study in 2013 of all individuals aged 75 years and older (17 203) in the county of Blekinge in the southeast of Sweden. Participants
Lin28b controls a neonatal to adult switch in B cell positive selection
The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice.
Production and utilisation of prebiotic oligosaccharides : Applied bioinformatics of glycoside hydrolases
The Cost-effectiveness of Biological Therapy Cycles in the Management of Crohn's Disease
OBJECTIVES: To examine the cost-effectiveness of continued treatment for patients with moderate-severe Crohn's disease in clinical remission, with a combination of anti-tumour necrosis factor alpha [anti-TNFα] [infliximab] and immunomodulator therapy compared with two different withdrawal strategies: [1] withdrawal of the anti-TNFα therapy; and [2] withdrawal of the immunomodulator therapy, respec
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke : Meta-Analysis of Population-Based Studies Involving 17 180 Individuals
Rationale: Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking. Objective: To determine whether circulating levels of MCP-1 are associated with risk
Examining social inclusion through music education: Two Swedish case studies
Since music education can be regarded as an arena for construction, performance and negotiation of cultural meaning and norms of values, the field of music education has, during the last decades, become aware of the need to locate issues of facing music within social questions (Jorgensen, 2003; DeNora, 2000; Wright, 2010). One central concept within this discussion is social inclusion. However, is
Cognitive and Neuroanatomic Accounts of Referential Communication in Focal Dementia
The primary function of language is to communicate-that is, to make individuals reach a state of mutual understanding about a particular thought or idea. Accordingly, daily communication is truly a task of social coordination. Indeed, successful interactions require individuals to (1) track and adopt a partner's perspective and (2) continuously shift between the numerous elements relevant to the e
Early breast cancer : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Genetic differentiation predicts body size divergence between island and mainland populations of common wall lizards (Podarcis muralis)
Small-bodied vertebrates sometimes evolve gigantism on islands, but there is a lack of consistent association with ecological factors or island characteristics. One possible reason is that, even if the ecological conditions are right, body size might fail to diverge on islands that were isolated recently or if there is gene flow between islands and the mainland. We studied body size, ventral colou
Analysis of Biased Competition and Cooperation for Attention in the Cerebral Cortex
A new approach to understanding the interaction between cortical areas is provided by a mathematical analysis of biased competition, which describes many interactions between cortical areas, including those involved in top-down attention. The analysis helps to elucidate the principles of operation of such cortical systems, and in particular the parameter values within which biased competition oper
Synthesis, Thermal Properties, and Rheological Characteristics of Indole-Based Aromatic Polyesters
Currently, there is an intensive development of bio-based aromatic building blocks to replace fossil-based terephthalates used for poly(ethylene terephthalate) production. Indole is a ubiquitous aromatic unit in nature, which has great potential as a bio-based feedstock for polymers or plastics. In this study, we describe the synthesis and characterization of new indole-based dicarboxylate monomer
Offshore outsourcing : An IT-manager perspective on cultural differences
— Cultural difference is a term often used when discussing problems in offshoring and offshore outsourcing, but only a few authors discuss solutions to bridge pointed out cultural gaps. In this paper earlier research is compared with an IT-manager perspective on experienced cultural differences. Cultural differences were found to include multiple dimensions: cultural distances, cognitive distances
Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
Background Excess weight gain throughout adulthood can lead to adverse clinical outcomes and are influenced by complex factors that are difficult to measure in free-living individuals. Metabolite profiling offers an opportunity to systematically discover new predictors for weight gain that are relatively easy to measure compared to traditional approaches. Methods and results Using baseline metabol