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In-beam background suppression shield

The long (3 ms) proton pulse of the European Spallation Source (ESS) gives rise to unique and potentially high backgrounds for the instrument suite. In such a source an instrument's capabilities will be limited by its Signal to Noise (S/N) ratio. The instruments with a direct view of the moderator, which do not use a bender to help mitigate the fast neutron background, are the most challenging. Fo

The impact of gonadotropin receptor polymorphisms on human reproductive function

To date, approximately 15% of all couples worldwide suffer from infertility. The management include controlledovarian hyper-stimulation of the women with follicle-stimulating hormone (FSH) and semen analysis of the men,prior to in vitro fertilization (IVF) and transfer of the fertilized embryo to the uterine cavity. Approximately 250 000IVF cycles are performed worldwide each year, and as a result

Development and production of Non Evaporable Getter coatings for the vacuum chambers of the 3 GeV storage ring of MAX IV

MAX IV is presently under construction at Lund, Sweden, and the first beam for the production of synchrotron radiation is expected to circulate in 2016. The whole set of 3 GeV ring beam pipes is coated with Ti-Zr-V Non Evaporable Getter (NEG) thin film in order to fulfil the average pressure requirement of 1×10-9 mbar, despite the compact magnet layout and the large aspect ratio of the vacuum cham

Forecasting global atmospheric CO2

A new global atmospheric carbon dioxide (CO2) real-time forecast is now available as part of the pre- operational Monitoring of Atmospheric Composition and Climate – Interim Implementation (MACC-II) service us- ing the infrastructure of the European Centre for Medium- Range Weather Forecasts (ECMWF) Integrated Forecast- ing System (IFS). One of the strengths of the CO2 fore- casting system is that

Electroencephalographic characteristics of status epilepticus after cardiac arrest

Objective: To describe the electrophysiological characteristics and pathophysiological significance of electrographic status epilepticus (ESE) after cardiac arrest and specifically compare patients with unequivocal ESE to patients with rhythmic or periodic borderline patterns defined as possible ESE. Methods: Retrospective cohort study of consecutive patients treated with targeted temperature mana

Muco-epidermoid tumour of the bronchus

A 7-year-old boy with recurrent pneumonia of the right lower lobe is described. At bronchoscopy a small tumour almost totally obliterating the right lower lobe was detected. Surgical treatment was undertaken. Histopathologic studies showed findings consistent with those of a muco-epidermoid tumour. The case emphasizes bronchoscopy as an important investigation in children with recurrent pneumonia.

Endometrial cancer risk prediction including serum-based biomarkers : results from the EPIC cohort

Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we

Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tum

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT

Carrier testing and prenatal diagnosis of haemophilia - utilisation and psychological consequences

Attitudes towards prenatal diagnosis, and abortion vary widely between different countries, religions, cultures and over time. Carrier testing and prenatal diagnosis (PD) of haemophilia have become an integrated part of the comprehensive care for haemophilia in Sweden as well as in many other countries. Almost all carriers are interested in carrier testing if they are aware of the possibility. Wit

Characterization of resident lymphocytes in human pancreatic islets

The current view of type 1 diabetes (T1D) is that it is an immune-mediated disease where lymphocytes infiltrate the pancreatic islets, promote killing of beta cells and cause overt diabetes. Although tissue resident immune cells have been demonstrated in several organs, the composition of lymphocytes in human healthy pancreatic islets have been scarcely studied. Here we aimed to investigate the ph

Wind tunnel as a tool in bird migration research

Wind tunnels, in which birds fly against an artificially generated air flow, have since long been used to evaluate aerodynamic properties of steady bird flight. A new generation of wind tunnels has also allowed the many processes associated with migratory flights to be studied in captivity. We review how wind tunnel studies of aerodynamics and migratory performance together have helped advancing o

The importance of genetic factors for the development of arthropathy : A longitudinal study of children and adolescents with haemophilia A

Haemophilia A is a congenital bleeding disorder characterised by recurrent haemorrhages into the major joints. Haemophilic arthropathy is a well-established outcome of recurrent joint bleeding; however, it is clear that multiple factors determine the extent and severity of its occurrence. We sought to identify genetic factors related to abnormalities in range of motion (ROM) in the knees, ankles a

Dietary adherence is not dependent on the mode of diagnosis in children with coeliac disease

Aim: To compare the adherence to gluten-free diet between children with serology-based and biopsy-proven coeliac disease. Methods: Medical records were retrospectively reviewed in 257 Swedish children diagnosed with coeliac disease between 2012 and 2019 at a tertiary hospital. Adherence to a gluten-free diet was systematically assessed by trained dietitians at follow-up. Mixed models were used to

Restricted plant diversity limits carbon recapture after wildfire in warming boreal forests

Incomplete wildfire combustion in boreal forests leaves behind legacy plant-soil feedbacks known to restrict plant biodiversity. These restrictions can inhibit carbon recapture after fire by limiting ecosystem transition to vegetation growth patterns that are capable of offsetting warmth-enhanced soil decomposition under climate change. Here, we field-surveyed plant regrowth conditions 2 years aft

Matrix element corrections in top quark decays for the tt¯W± process

We present a method that allows enabling matrix element corrections (MECs) in Pythia8 with MC@NLO matching, without incurring double counting. MECs are an interesting feature that may contribute to the accuracy of theoretical predictions, alongside matching and merging. We directly compare our method to a specific choice of settings in Pythia8, which can remove double-counting for MECs in certain