Objectives: Subarachnoid haemorrhage (SAH) carries a high burden of morbidity and mortality. One in three patients develop vasospasm, which is associated with Delayed Cerebral Ischemia. The pathophysiology includes vasoconstrictor receptor upregulation in cerebral arteries. The protein kinase C – inhibitor RO-31-7549 reduces the expression of several vasoconstrictor receptors and normalizes cerebr

Fibroblasts are adherent cells that maintain tissue homeostasis by sensing and responding to the extracellular matrix (ECM). Focal adhesions (FAs) link these ECM changes to actomyosin dynamics through changes in its composition, influencing cellular response. Septin-7 (Sept-7) has previously been found in FA proteomics studies and shown to influence ECM sensing. Using total internal reflection mic

Background: Intervention trials that have demonstrated significant effects may not always replicate those effects when scaled up. This study aimed to test whether scaling-up a successful cluster randomized trial (the COMMUNICATE study, 9 intervention communities), which promoted population-level physical activity (PA), could promote PA in a broader citywide setting (29 communities) after two years

In this study, the precipitation trend was investigated by linear regression and Mann-Kendall test using the daily data from 1961 to 2010.

In this paper, we extend the control contraction metrics (CCM) approach, which was originally proposed for the universal tracking control of nonlinear systems, to those that evolves on Lie groups. Our idea is to view the manifold as a constrained set that is embedded in Euclidean space, and then propose the sufficient conditions for the existence of a CCM and the associated controller design. Nota

In the following study, using highly-developed remote sensing methodologies, a historical over-ten-year study of the LULC phenomenon of the Khorezm Oasis was conducted. The analysis provides valuable insights about agricultural change, water management policies and the alteration of LULC in the region, including several processes, changes in plants and irrigation levels, population density and gro

We study dynamical optimal transport of discrete time systems (dDOT) with Lagrangian cost. The problem is approached by combining optimal control and Kantorovich duality theory. Based on the derived solution, a first order splitting algorithm is proposed for numerical implementation. While solving partial differential equations is often required in the continuous time case, a salient feature of ou

We investigate optimal mass transport problem of affine-nonlinear dynamical systems with input and density constraints. Three algorithms are proposed to tackle this problem, including two Uzawa-type methods and a splitting algorithm based on the Douglas-Rachford algorithm. Some preliminary simulation results are presented to demonstrate the effectiveness of our approaches.

Purpose: This article proposes diffractive vignettes as a new analytical approach that can sensitize organizational communication research to extra/linguistic forces in the communicative constitution of major societal challenges such as the climate crisis. The critical feminist concept of diffraction examines how diverse forces interact, interfere, and produce new patterns of meaning and differenc

The World Meteorological Organization (WMO) Global Atmosphere Watch (GAW) coordinates high-quality atmospheric greenhouse gas observations globally and provides these observations through the WMO World Data Centre for Greenhouse Gases (WDCGG) supported by Japan Meteorological Agency. The WDCGG and the National Oceanic and Atmospheric Administration (NOAA) analyse these measurements using different