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Electrochemical real-time monitoring of ligand binding to an engineered opioid receptor specific for morphine is reported. In the particular systems studied, 90% of the binding was found to be completed after only 85-120 s. Thus, the binding kinetics has proven to be more rapid than previously believed. The observed association rate constant for the morphine binding reaction was calculated to be 2

In the male moth, Agrotis ipsilon, the neuronal basis for juvenile hormone (JH)-linked modulation of sex pheromone responsiveness was investigated following stimulation of the antenna with i) an extract of female pheromone gland, ii) the synthetic pheromone blends from A. ipsilon and a closely related species, A. segetum, and iii) single components of the A. ipsilon blend. Response characteristics

Objective. Renal concentrating capacity (RCC) has been used as a tool in the diagnosis of the site of urinary tract infection (UTI). In this study, RCC was measured in women with symptoms of UTI in relation to the clinical picture and the bacterial species isolated. Material and methods. In 633 outpatients aged >= 18 years with symptoms of UTI, a renal concentration test with desmopressin was perf

Popular Abstract in Swedish Avhandlingen fokuserar på den andra vågen av järnålderns centrala platser, vilka formerades under det långa 600-talet. Utgångspunkten är en fallstudie av en aristokratisk miljö i Järrestad, sydöstra Skåne. Två problemkomplex bearbetas. Tolkningen av de förkristna aristokratiska miljöerna. Syftet är att undersöka hur härskarideologier gestaltades i hallmiljön och det omThis dissertation focuses on the second wave of central places in south Scandinavia, emerging during the prolonged 7th century. The point of departure is a case study of an aristocratic setting in Järrestad, situated in the southernmost part of Sweden. Two problem complexes are tackled: 1. The interpretation of the pre-Christian aristocratic settings. The aim is to investigate the staging of rule

Previously we observed that neural cell adhesion molecule (NCAM) deficiency in P tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient P cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibro

In stroke patients several cardiac changes associated with embolism can be detected with transoesophageal echocardiography. Potential major cardiac embolic sources (e.g. atrial fibrillation, thrombi of left ventricle/atrium, vegetation, myxoma, dilated cardiomyopathy) have a causal relationship to embolism. Other changes with no certain causal relationship are regarded as potential minor cardiac e

Superdeformed and highly deformed rotational bands were established in Zn-65 using the Ca-40(Si-29,4p)Zn-65 reaction, and averaged quadrupole moments were measured for two of these bands. The configurations of these bands were assigned based on Hartree-Fock calculations. One of the three bands exhibits at low (h) over bar omega a rise in the J((2)) dynamic moments of inertia that is similar to the

Popular Abstract in Swedish Interaktionen i fyra olika utvecklingssamtal från åldringsvård, industri och skola beskrivs i den här avhandlingen. Till grund ligger kritisk analys av samtalens situationella kontext, organisation och språkliga uttrycksformer. Resultaten jämförs också med hur samtalsdeltagarna själva bedömer interaktionen. Utvecklingsamtalen visar sig inte vara så ömsesidiga som de tiThis dissertation is an investigation into Swedish “utvecklingssamtal”, i.e. a kind of annual, re-curring staff development talk. The investigation consists of four empirical analyses. The first analysis concerns the situational context. The second analysis concerns the structure of the talks, the content and informal organisation. In the third analysis, I have worked quite closely to the theoreti

Mechanised production of peat for fuel consumption is associated with high concentrations of organic dust, which is inhaled by the peat workers. In the present study 17 workers at two peat bogs in northern Sweden were examined. Personal sampling of total dust and the respirable fraction was performed during several workshifts. Dynamic spirometry was carried out before and at the end of shifts. Bro

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to

The topic of this thesis is the study of finite volume methods for hyperbolic conservation laws on non-uniform meshes. A high-order hyperbolic reconstruction method is presented. The method is constructed for quadrilateral meshes, since more realistic hyperbolic problems involve more complicated problem domains than the standard rectangular ones. The method is an extension of the well known

The processing advantage for words in the right visual field (RVF) has often been assigned to parallel orthographic analysis by the left hemisphere and sequential by the right. The authors investigated this notion using the Reicher–Wheeler task to suppress influences of guesswork and an eye-tracker to ensure central fixation. RVF advantages obtained for all serial positions and identical U-shaped

Selected papers from the 2002 Conference in the Pepperdine University lecture hall facilities in Heidelberg.

Flint has a limited distribution in the Scandinavian area, natural sources being largely confined to the southern regions. Here, the use of flint for making daggers and polished axes during the Neolithic is widespread and extensive. There is also evidence for mining of flint at Södra Sallerup in southern Sweden and on several sites in Denmark, but flint is available in till deposits as well. The

In this paper an approximate expression for the first inverse moment sf(1 - lambda) Sigma(k=1)(t) lambda(t-k)phi(k)phi(k)(T) + lambda(t) (1 - lambda)P-0(i-1), where phi(k) is a Gaussian stationary vector process is derived. This generalized quadratic form is the estimate of the information matrix when using the Recursive Least Squares (RLS) algorithm with forgetting factor. This estimator is commo