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Low-dimensional dynamics of globally coupled complex Riccati equations : Exact firing-rate equations for spiking neurons with clustered substructure

We report on an exact theory for ensembles of globally coupled, heterogeneous complex Riccati equations. A drastic dimensionality reduction to a few ordinary differential equations is achieved for Lorentzian heterogeneity. By applying this technique, we obtain low-dimensional firing-rate equations for populations of spiking neurons with a clustered substructure.

Rediscovering uncertainty in social work : The case of anonymous text-based encounters online

Uncertainty has long been discussed in social work as an inherent element of professional practice. The present paper extends this discussion into the realm of digital social work. It reports a study of anonymous text-based online counselling provided by the social services in Sweden. We explore what kind of uncertainty is evoked when social workers respond to anonymous users through online platfo

Distinct Signatures of Chromosomal Involvement in 59 251 Translocations Across 58 Tumor Types. A Novel Perspective

Chromosomal translocations are key events in cancer, driving oncogenesis by disrupting and deregulating critical genes. While specific tumor-associated translocations are well studied, the frequencies and distributions of most remain unknown. Additionally, the role of chromosomal reshuffling in translocations has received little attention. This study presents data on the chromosomal involvement in

Excipient effect on phenol-induced precipitation of human growth hormone and bovine serum albumin

The aim of this study was to investigate the impact of phenol on the precipitation of bovine serum albumin (BSA) and human growth hormone (hGH), in the presence of other excipients frequently used in biological drugs for parenteral delivery. The focus of the study lieson incompatibilities observed in multidose formulations containing non-ionic surfactants and preservatives. Previous research has s

Chapter 6. How environmental and social contexts shape and constrain rhythm structure and production

To survive, animals have tuned their behaviors to the socio-environmental conditions offered by their habitats and communities. This also applies to communicative behaviors, which can be simultaneously constrained by a number of external factors. Hence, an animal’s surroundings narrow the optimal parameters for effective communication to well within the limits of what it is capable of producing. I

Estimating charging infrastructure demand for electric vehicles : a systematic review

Establishing robust charging infrastructure is crucial for electric vehicle (EV) adoption. This study addresses the lack of systematic literature reviews examining the global charging infrastructure research landscape with a comprehensive review of English literature published between 2017 and 2023. We screened 12237 records, and analyzed 137 peer-reviewed and 31 grey literature studies. Findings

Experimental Demonstration of a Spectral Fingerprint for the Saddle and Inverted Conformations of Porphyrins on Copper

Combined density functional theory (DFT) and X-ray standing wave (XSW) studies have previously provided evidence for the preferential adoption of an inverted conformation of 2H-TPP on Cu(111) in contrast to the saddle conformation usually favored by porphyrin molecules adsorbed on metals. We experimentally demonstrate, via X-ray photoelectron spectroscopy (XPS) analysis, that the binding energies

Phosphorescence-based O2 sensing reveals size-dependent survival and motility of metastatic prostate cancer cells in self-generated hypoxia

Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to visualize the self-generated hypoxia field of prostate cancer cells and quantify local O2 consumption rates, mea

Impact of the risk-adapted Nordic anal cancer group consensus guidelines on the contouring of the elective clinical target volume in anal cancer

Background and purpose: The recently published Nordic anal cancer group (NOAC) contouring guidelines aim for improved oncological outcomes and reduced toxicity in anal cancer patients treated with radiotherapy. The present work describes how the elective clinical target volume (CTVe) would change when applying the NOAC guidelines instead of the previous Australasian standard. According to the Aust

Status and perspective of protein crystallography at the first multi-bend achromat based synchrotron MAX IV

The first multi-bend achromat based synchrotron MAX IV operates two protein crystallography beamlines, BioMAX and MicroMAX. BioMAX is designed as a versatile, stable, high-throughput beamline catering for most protein crystallography experiments. MicroMAX is a more ambitious beamline dedicated to serial crystallography including time-resolved experiments. Both beamlines exploit the special charact