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Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels. Several DPP-4 inhibitors are in clinical development. Most experience so far has been with sitag
An undergraduate course in Strategic Management seemingly provides similar basic content to students including the infamous SWOT (strengths, weaknesses, opportunities and threat) analysis along with the identification of functional level, business level, and generic strategies to enhance an organization’s competitiveness. One of the most common resources for this type of course is the article outl
This thesis is a study of configurations of identity in American mainstream comics. It focuses on how a small number of writers of Jewish descent have expressed or disciplined their Jewishness in relation to their creations. In an attempt to revise common linear narratives, the thesis presents three case studies of famous and influential comics texts with different primary foci: a chapter on SuperPopular Abstract in English The publication of Michael Chabon’s Pulitzer-prize winning novel The Amazing Adventures of Kavalier & Clay (2000) brought the Jewish–comics connection to popular attention. The novel illuminated the fact that many of the pioneers of American mainstream comics were Jewish. Owing to this history, and to the fact that there today exists a large and growing library of s
We are reporting on a novel approach for structured immobilisation of enzymes on gold surfaces modified with monolayers of functionalised alkylthiols. The formation of enzyme spots is achieved by shooting very small volumes of an appropriate enzyme solution (down to 100 pl) onto a thiol-monolayer modified gold surface using a micro-dispenser. Formation of enzyme patterns is obtained by moving the
A limitation on the extinction cross section, valid for all scatterers satisfying some basic physical assumptions, is investigated. The physical limitation is obtained from the holomorphic properties of the forward scattering dyadic. The analysis focuses on the consequences for materials with negative permittivity and permeability, i.e. metamaterials. From a broadband point of view, the limitation
Kulturartikel om framgången både nationellt och internationellt för den Sydkoreanska filmen i början av 2000-talet.
Kulturartikel om serieromanförfattaren Alan Moore med anledning av filmverrsionen av hans roman Watchmen.
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Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association be
Concrete structures in hydro power plants exposed to harsh environment, such as non-frozen freshwater and long cold winters with freezing temperatures, are always in the danger-zone for suffering from concrete damages. Some existing concrete structures already suffer from different damages caused by high water content. The conditions regarding concrete quality, air entrainment, temperature and tim
BackgroundA suspected occult hip fracture after normal radiography is not uncommon in an elderly person after a fall. Despite a lack of robust validation in the literature, computed tomography (CT) is often used as secondary imaging.PurposeTo assess the frequency and clinical utility of non-cortical skeletal and soft tissue lesions as ancillary fracture signs in CT diagnosis of occult hip fracture
The time-dependent scattering by a spherical cavity in an elastic half space is considered. The incoming wave is a pulsed Rayleigh wave. The stationary part of the problem is solved by the T-matrix method, and an integration in frequency is performed with a modified gaussian weight function. The displacement components at some points on the surface of the half space are computed and shown in a num
This study aimed to investigate the growth rate of 31 consecutive invasive breast cancers based on volume measures on at least two serial mammograms and its relation to histopathological findings. The average tumour volume-doubling time in all invasive breast cancer subtypes was 282 d (range 46-749 d). Grade III breast cancers had a significantly shorter average tumour volume-doubling time of 105
A compact fluorosensor using three different ultraviolet light-emission diodes as excitation sources for fiber-optic recording of fluorescence 10 spectra from samples is described. A compact integrated spectrometer with linear array wavelength recording is used, yielding a spectral resolution 11 of about 8 nm. In two system implementations ultraviolet light-emitting diodes at 300, 340 and 395 nm,
CONCLUSION: The properties of a foam surface significantly affect body movement variance. Therefore, studies where different kinds of foam have been used may not provide congruent results. OBJECTIVES: To investigate whether different properties of foam affect body movement variance (32 subjects, mean age 22.5 years) in terms of linear head, shoulder, hip and knee movements. Subjects repeated tests
