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Deep learning for segmentation of 49 selected bones in CT scans : First step in automated PET/CT-based 3D quantification of skeletal metastases

Purpose: The aim of this study was to develop a deep learning-based method for segmentation of bones in CT scans and test its accuracy compared to manual delineation, as a first step in the creation of an automated PET/CT-based method for quantifying skeletal tumour burden. Methods: Convolutional neural networks (CNNs) were trained to segment 49 bones using manual segmentations from 100 CT scans.

Chromatographic separation of hemoglobin variants using robust molecularly imprinted polymers

Devising a robust, efficient and cost effective hemoglobin (Hb) purification strategy is one of the key challenges in the development of Hb-based blood substitutes. The aim of this study was to use molecularly imprinted polymers (MIPs) as a novel and efficient chromatographic resin to selectively recognize and purify different Hb variants. The results showed that the Hb-MIP material developed here

Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11

Objectives: Non-small cell lung cancer (NSCLC) is a heterogeneous disease with unique combinations of somatic molecular alterations in individual patients, as well as significant differences in populations across the world with regard to mutation spectra and mutation frequencies. Here we aim to describe mutational patterns and linked clinical parameters in a population-based NSCLC cohort. Material

Steroids for Acute Vestibular Neuronitis-the Earlier the Treatment, the Better the Outcome?

OBJECTIVE: To present findings that suggest steroid treatment within 24 hours of onset of vestibular neuronitis results in better restitution of vestibular function than treatment between 25 and 72 hours. PATIENTS: Thirty-three consecutive patients (17 men, 16 women, mean age 57 yr, range 17-85 yr) with acute vestibular neuronitis and treated with steroids within 72 hours after symptom onset. Pati

Human G protein-coupled Receptor 30 (GPR30) is N -glycosylated and N-terminal Domain Asparagine 44 is Required for Receptor Structure and Activity

GPR30, or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor

Effects of adjuvant tamoxifen over three decades on breast cancer–free and distant recurrence–free interval among premenopausal women with oestrogen receptor–positive breast cancer randomised in the Swedish SBII:2pre trial

Aims: The primary aim was to compare 2 years of adjuvant tamoxifen versus no systemic treatment in premenopausal patients with oestrogen receptor (ER)–positive tumours, regarding breast cancer–free interval (BCFi) and distant recurrence–free interval (D-RFi), with 30 years of follow-up and for specified intervals. Moreover, we aimed to investigate the effects of adjuvant tamoxifen on the incidence

Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women.This thesis investigated biological events in ovarian cancer, which were translated into clinically relevant observations using differ

High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke

Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted. We aimed to study release mechanisms of LOX -1 and how circulating levels of soluble LOX -1 ( sLOX -1) relate to plaque inflammation and future risk for ischemic stroke. Methods an

Interatrial block in prediction of all-cause mortality after first-ever ischemic stroke

Background: Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predicted all-cause mortality during 10 years after ischemic stroke. Methods: The study sample comprised 235 patients (median age 74 (interquartile range 25-75% 65-81) years, 95 female)

Hip pain in children with cerebral palsy : A population-based registry study of risk factors 11 Medical and Health Sciences 1103 Clinical Sciences

Background: Hip pain is prevalent in children with cerebral palsy (CP). Hip displacement is a known risk factor for hip pain. However, many children do not have displaced hips but still have hip pain and the aetiologies are poorly understood. The aims of this study were to investigate: 1. the prevalence of hip pain related to age, gender, gross motor function, degree of hip displacement and 2. the

Monitoring respiration using the pressure sensors in a dialysis machine

OBJECTIVE: Although respiratory problems are common among patients with end-stage renal disease, respiration is not continuously monitored during dialysis. The purpose of the present study is to investigate the feasibility of monitoring respiration using the pressure sensors of the dialysis machine. APPROACH: Respiration induces variations in the blood pressure that propagates to the extracorporea

Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. Methods: Formalin-fixed paraffin-embedded tissue

The early identification of disease progression in patients with suspected infection presenting to the emergency department : A multi-centre derivation and validation study

Background: There is a lack of validated tools to assess potential disease progression and hospitalisation decisions in patients presenting to the emergency department (ED) with a suspected infection. This study aimed to identify suitable blood biomarkers (MR-proADM, PCT, lactate and CRP) or clinical scores (SIRS, SOFA, qSOFA, NEWS and CRB-65) to fulfil this unmet clinical need. Methods: An observ

Suppression of Λ(1520) resonance production in central Pb-Pb collisions at s NN =2.76 TeV

The production yield of the Λ(1520) baryon resonance is measured at midrapidity in Pb-Pb collisions at sNN = 2.76 TeV with the ALICE detector at the Large Hadron Collider (LHC). The measurement is performed in the Λ(1520)→pK- (and charge conjugate) hadronic decay channel as a function of the transverse momentum (pT) and collision centrality. The ratio of the pT-integrated production of Λ(1520) bar

Experimental Characterization of Acoustic Streaming in Gradients of Density and Compressibility

Suppression of boundary-driven Rayleigh streaming has recently been demonstrated for fluids of spatial inhomogeneity in density and compressibility owing to the competition between the boundary-layer-induced streaming stress and the inhomogeneity-induced acoustic body force. To understand the implications of this for acoustofluidic particle handling in the submicrometer regime, we here characteriz

Diatom-oxygen isotope record from high-altitude Lake Petit (2200 m a.s.l.) in the Mediterranean Alps : Shedding light on a climatic pulse at 4.2 ka

In the Mediterranean area, the 4.2 ka BP event is recorded with contrasting expressions between regions. In the southern Alps, the high-altitude Lake Petit (Mercantour Massif, France; 2200 m a.s.l.) offers pollen and diatom-rich sediments covering the last 4800 years. A multi-proxy analysis recently revealed a detrital pulse around 4200 cal BP due to increasing erosion in the lake catchment. The

Brigantiaea crystallina (Ascomycota, Teloschistales), a new species from South Korea and Japan.

Förra sommaren gästades SLF den 13–17 juni av den brittiska motsvarigheten BLS genom en inbjudan av Lars Borg, som ibland gästat deras exkursioner i England. Vi var förlagda till Allégården i Kastlösa på Öland varifrån vi gjorde utflykter till olikadelar av södra och mellersta Öland. En halvdag ägnades också åt en typiskt sur tallskog på fastlandet i närheten av Kalmar. Här berättar Ulf om den hisBrigantiaea crystallina Arup is described as new to science from South Korea and Japan. It is similar to B. purpurata but has a pale to pale brownish orange hypothecium, an excipulum penetrated by brownish orange anthraquinonecrystals as well as colourless crystals that appear white in polarised light, the spores are smaller and the thallus lacks zeorine. The new species is illustrated and compare