To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3- and factor B (FB)-deficient (C3(-/-) and FB-/-) DBA/1J mice using well-defined monoclonal IgG2b and IgG2a antibodies to type II collagen. In control DBA/1J mice, severe swelling of the joints, destruction of cartilage and erosion of bone develo

The southern section of the Mylonite Zone (MZ) is a major lithotectonic terrane boundary in the SW Baltic Shield. It separates the parautochthonous Eastern Segment of the Sveconorwegian orogen from the allochthonous Western Segment. Complex zircons in migmatised and banded orthogneisses along the southern MZ were investigated by ion microprobe analyses guided by backscattered electron imaging to d

A hidden Markov regime is a Markov process that governs the time or space dependent distributions of an observed stochastic process. We propose a recursive algorithm for parameter estimation in a switching autoregressive process governed by a hidden Markov chain. A common approach to the recursive estimation problem is to base the estimation on suboptimal modifications of Kalman filtering techniqu

Combined treatment with electroremediation and sulphate reducing bacteria (SRB) was tested in laboratory and pilot scale. The contaminated soil came from a chlor-alkali factory and contained about 100 mg/kg Hg. Iodide/iodine complexing agent was used to mobilize mercury. Mercury iodide complexes were moved to the anode solution using an electric field. The anode solution was then mixed with hydrog

The copper coordination geometry in the blue copper proteins plastocyanin, nitrite reductase, cucumber basic protein, and azurin has been studied by combined density functional (B3LYP) and molecular mechanical methods. Compared to quantum chemical vacuum calculations, a significant improvement of the geometry is seen (toward the experimental structures) not only for the dihedral angles of the liga

There is currently no effective vaccine for Neisseria meningitidis (Nm) serogroup B. Generation of optimal immune responses to meningococci could be achieved by targeting meningococcal antigens to human dendritic cells (DCs). Recent studies have shown that diverse DC responses and subsequent generation of protective immunity can be observed if the microbes are viable or killed. This is important b

Background and purpose: The purpose of this work was a comparison of realistic IMRT plans based on the same CT-image data set and a common predefined set of dose objectives for the planning target volume and the organs at risk. This work was part of the larger European QUASIMODO IMRT verification project. Materials and methods: Eleven IMRT. plans were produced by nine different European groups, ea

We report on the development of a bi-layer bi-enzyme biosensor architecture using different peroxidases and alcohol oxidase from Hansenula polymorpha C-105 as biological recognition elements. The sensor architecture comprises a first layer containing either horseradish peroxidase or royal palm tree peroxidase crosslinked with an Osmium complex-modified redox hydrogel. On top, a second layer was fo

Previous time series evidence has indicated that farmland prices and cash rents are not cointegrated, a finding at odds with the present value model of farmland prices. We argue that this failure to find cointegration may be due to low power of tests and to the presence of structural change representing a shifting risk premium on farmland investments. To accommodate this possibility, we use panel

The objective of this investigation was to study regional absorption of inhaled insulin together with an enhancer (sodium di-octyl-sulfosuccinate [DOSS]) in the rabbit airways and lung. Insulin was administered with or without DOSS by aerosol inhalation, intratracheal infusion, intranasally, sublingually, and without DOSS intravenously. Blood glucose and plasma levels of insulin were measured duri

In this study, we report the isolation and characterization of osteocalcin in human urine using mass spectrometry and N-terminal sequencing. Multiple proteolytic forms of osteocalcin were found, which consisted of 16-27 residues from the middle region of the molecule. Several fragments had residue Gly7 at the N-terminus and the most predominant was fragment 7-31. Additional fragments starting from

Popular Abstract in Swedish För att en organism ska fungera är det nödvändigt att alla de celler som bygger upp organismen kommunicerar med varandra. Denna kommunikation sker genom att speciella proteiner på cellens yta, s.k. receptorer, tar emot signaler från andra celler. G-proteinkopplade receptorer (GPCR) är den vanligaste typen av receptorer. Då en signalmolekyl binder till en GPCR ändrar deIn all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where

We reviewed after 48 (24-90) months the clinical results in 45 cases of revision hip arthroplasties where an uncemented, long-stem femoral prosthesis (BIAS, Zimmer) had been used. A subgroup of 13 cases was followed with radiostereometric analysis (RSA) for 2 years. 3/45 cases had been revised, another 12 had unsatisfactory pain scores. The median Harris score was 69 (26-99). 12/13 stems migrated;

The relationship between morality and perceptual defense mechanisms was studied. Three new scales were constructed to measure different aspects of morality: moralism (the tendency to evaluate everything in terms of right and wrong), conscience (strength of feelings of right and wrong) and reparation (inclination to repair the damage one has caused). Perceptual defense mechanisms were measured with

In hepatocytes from fed rats, ethanol significantly increased fatty acid esterification but had little effect on fatty acid oxidation.

An analytical model is developed to calculate recession distance and eroded volume for coastal dunes during severe storms. The transport relationship used in the model is based on wave impact theory, where individual swash waves hitting the dune face induce the erosion. Combining this relationship with the sediment volume conservation equation describes the response of the dune to high waves and w

The aim of this study is to try and explain the relationship between violence and the changes taking place in social spaces. Violence, in all its dimensions, has taken a central place in Latin American social life and has become an almost totally private issue. This implies a series of spatial and social transformations in the cities. The new effects of violence influence social and ethnic segrega