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Solar forcing as an important trigger for West Greenland sea-ice variability over the last millennium

Arctic sea ice represents an important component of the climate system, and the present reduction of sea ice in the Arctic is of major concern. Despite its importance, little is known about past changes in sea-ice cover and the underlying forcing mechanisms. Here, we use diatom assemblages from a marine sediment core collected from the West Greenland shelf to reconstruct changes in sea-ice cover o

The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.

The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional c

Pelagic-benthic coupling within an upwelling system of the subtropical northeast Atlantic over the last 35 ka BP

We present a high resolution, multiproxy study of the relationship between pelagic and benthic environments of a coastal upwelling system in the subtropical NE Atlantic Ocean. Marine sediments corresponding to late MIS3 to the Holocene in the radiocarbon dated core GeoB7926, retrieved off Mauritania (21 degrees N) were analysed to reconstruct productivity in surface waters and its linkage to deep

A new key pole for the East European Craton at 1452 Ma: Palaeomagnetic and geochronological constraints from mafic rocks in the Lake Ladoga region (Russian Karelia)

Palaeomagnetic and geochronological studies on mafic rocks in the Lake Ladoga region in South Russian Karelia provide a new, reliably dated Mesoproterozoic key paleopole for the East European Craton (Baltica). U-Pb dating on baddeleyite gives a crystallisation age of 1452 +/- 12 Ma for one of the studied dolerite dykes. A mean palaeomagnetic pole for the Mesoproterozoic dolerite dykes. Valaam sill

Furongian (Cambrian) agnostoids of Scandinavia and their implications for intercontinental correlation

Out of the 14 agnostoid species/subspecies so far recorded from the Furongian of Scandinavia, seven are excellent biostratigraphical indices and important for correlation between Baltica and other palaeocontinents. Glyptagnostus reticulatus, Aspidagnostus lunulosus and Agnostus (Homagnostus) obesus first appear at the base of the G. reticulatus Zone, allowing a precise correlation of the base of t

Dispersion of overdamped diffusing particles in channel flows coupled to transverse acoustophoretic potentials: Transport regimes and scaling anomalies

We address the dispersion properties of overdamped Brownian particles migrating in a two-dimensional acoustophoretic microchannel, where a pressure-driven axial Stokes flow coexists with a transverse acoustophoretic potential. Depending on the number and symmetries of the stable nodal points of the acoustophoretic force with respect to the axial velocity profile, different convection-enhanced disp

Search for dark matter in events with a Z boson and missing transverse momentum in pp collisions at root s=8 TeV with the ATLAS detector

A search is presented for production of dark-matter particles recoiling against a leptonically decaying Z boson in 20.3 fb(-1) of pp collisions at root s = 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with large missing transverse momentum and two oppositely charged electrons or muons consistent with the decay of a Z boson are analyzed. No excess above the Standard Model pred

Polymer leaching from film coating: Effects on the coating transport properties.

The release mechanism of metoprolol succinate pellets coated with a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC) is mechanistically explained. The kinetics of drug release and HPC leaching were followed for drug doses. The coating was initially not permeable to the drug, and release started only after a critical amount of the

Contact allergy from disperse dyes in textiles-a review.

Several disperse dyes (DDs) are still considered to be the most important allergens in textile dermatitis, but there are sparse data about their current use in textiles. The aim of this review was to evaluate published studies and reports on contact allergy to DDs published in PubMed during the last 22 years (1990-2012). Prevalence data are provided by study and by dye, as well as by the described

Modification of Human-Biometeorologically Significant Radiant Flux Densities by Shading as Local Method to Mitigate Heat Stress in Summer within Urban Street Canyons

Increasing heat will be a significant problem for Central European cities in the future. Shading devices are discussed as a method to mitigate heat stress on citizens. To analyze the physical processes, which are characteristic of shading in terms of urban human-biometeorology, experimental investigations on the thermal effects of shading by a building and shading by tree canopies were conducted i

Journal of Scandinavian Cinema

The Journal of Scandinavian Cinema is a new scholarly journal devoted to film in the Scandinavian countries. It aims to become the prime site for excellent research and engaging discussions on cinema in Scandinavia, both within the national context of Denmark, Finland, Iceland, Norway and Sweden, and as a region existing in a globalized world.

Experimental Evaluation of the Response of Coastal Mediterranean Planktonic and Benthic Metabolism to Warming

The Mediterranean Sea has been identified as one of the hotspots for climate change. Intense warming in the Mediterranean Sea may have strong implications for biological activity and ecosystem functioning. To elucidate the effects of warming on planktonic and benthic metabolism, we performed experiments under different increasing temperature regimes, ranging from three to six different temperature

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of he

miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator.

Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri

A method of establishing a transect for biodiversity and ecosystem function monitoring across Europe

The establishment of the range of soil biodiversity found within European soils is needed to guide EU policy development regarding the protection of soil. Such a base-line should be collated from a wide-ranging sampling campaign to ensure that soil biodiversity from the majority of soil types, land-use or management systems, and European climatic (bio-geographical zones) were included. This paper

Dryland vegetation response to wet episode, not inherent shift in sensitivity to rainfall, behind Australia's role in 2011 global carbon sink anomaly

There is compelling new evidence that semi-arid ecosystems are playing a pivotal role in the inter-annual variability and greening trend of the global carbon cycle (Ahlström et al., 2015). The situation is exemplified by the vast inland region of Australia, the driest inhabited continent. Using a global model, Poulter et al. (2014) inferred that Australian ecosystems contributed 57% of a record gl