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Native language experience shapes pre-attentive foreign tone processing and guides rapid memory trace build-up : An ERP study

Language experience, particularly from our native language (L1), shapes our perception of other languages around us. The present study examined how L1 experience moulds the initial processing of foreign (L2) tone during acquisition. In particular, we investigated whether learners were able to rapidly forge new neural memory traces for novel tonal words, which was tracked by recording learners’ ERP

A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias

Background: Whole-genome sequencing (WGS) and whole-transcriptome sequencing (WTS), with the ability to provide comprehensive genomic information, have become the focal point of research interest as novel techniques that can support precision diagnostics in routine clinical care of patients with various cancer types, including hematological malignancies. This national multi-center study, led by Ge

The effect of patient and prosthesis factors on revision rates after total knee replacement using a multi-registry meta-analytic approach

BACKGROUND AND PURPOSE: Characteristics of patients receiving total knee arthroplasty (TKA) and prostheses used vary between regions and change with time. How these practice variations influence revision remains unclear. We combined registry data for better understanding of the impact of variation, which could potentially improve revision rates. PATIENTS AND METHODS: We used data from 2003 to 2019

Differences in genetic risk score profiles for drug use disorder, major depression, and ADHD as a function of sex, age at onset, recurrence, mode of ascertainment, and treatment

Do genetic risk profiles for drug use disorder (DUD), major depression (MD), and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex, age at onset (AAO), recurrence, mode of ascertainment, and treatment? Methods Family genetic risk scores (FGRS) for MD, anxiety disorders, bipolar disorder, schizophrenia, alcohol use disorder, DUD, ADHD, and autism-spectrum dis

Diagnostic contribution of multi-frequency vibrometry to detection of peripheral neuropathy in type 1 diabetes mellitus compared with nerve conduction studies

Aim The aim was to assess the use of multi-frequency vibrometry (MFV) in detecting diabetic peripheral neuropathy (DPN) in type 1 diabetes in comparison to nerve conduction studies (NCS) and neurothesiometer (NT). Our objectives were to examine how VPTs correlated with NCS parameters, evaluate the efficacy of MFV in distinguishing DPN as well as to investigate whether MFV procedure could be based

The Visions of St. Birgitta : A Study of the Making and Reception of Images in the Later Middle Ages

Visions, or revelations, played an enormously important role in late medieval society. So much so that the question what constituted an authentic vision was debated at the highest ecclesiastical levels. Furthermore, the majority of visionaries in this period were women, and visions afforded them with unique opportunities to exercise their abilities in contexts otherwise almost exclusively reservedVisions, or revelations, played an enormously important role in late medieval society. So much so that the question what constituted an authentic vision was debated at the highest ecclesiastical levels. Furthermore, the majority of visionaries in this period were women, and visions afforded them with unique opportunities to exercise their abilities in contexts otherwise almost exclusively reserved

Effectiveness of first generation disease-modifying therapy to prevent conversion to secondary progressive multiple sclerosis

Background: The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) has been associated with reduced relapse rates and accumulation of disability. However, studies examining impact of DMT on risk of transition to secondary progressive MS (SPMS) leveraging population-based nationwide data are still rare. Here, we determine the population incidence of conversion to SPMS using two co

Long-term linguistic outcome in adults with congenital cytomegalovirus infection

BACKGROUND: Congenital cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is still not well understood. This is the first study that presents linguistic follow-up data performed on adults who were infected in utero.METHOD: All individuals from a

Immunoassay-based quantification of full-length peptidylglycine alpha-amidating monooxygenase in human plasma

A one-step sandwich chemiluminescence immunometric assay (LIA) was developed for the quantification of bifunctional peptidylglycine-α-amidating monooxygenase (PAM) in human plasma (PAM-LIA). PAM is responsible for the activation of more than half of known peptide hormones through C-terminal α-amidation. The assay employed antibodies targeting specific catalytic PAM-subunits, peptidylglycine alpha-

How Pippi came to the German Democratic Republic

The first edition of Astrid Lindgren's book Pippi Langstrumpf (GDR/1975) is our starting point for this presentation. It is also our first joint presentation of our project “Pippi beyond the border” (The Foundation for Baltic and East European Studies). The aim of the project is to examine the complex reception history of Astrid Lindgren's classic children's book Pippi Longstocking in the GDR, whi

Postprandial triglyceride levels rather than fat distribution may reflect early signs of disturbed fat metabolism in Iraqi immigrants

Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Met

Selection of Weather Files and Their Importance for Building Performance Simulations in the Light of Climate Change and Urban Heat Islands

Building performance predictions and their reliability rely heavily on weather data inputs. Climate is affected by spatial and temporal differences related to climate change and urban heat island effects, but the weather files used in building performance simulations (BPS) often remain unchanged and may represent weather observations generated from inadequate space and time for their application.

Prevalence and treatment of hip displacement in children with cerebral palsy in Finland

Purpose: The aim was to study the prevalence of hip displacements, dislocations, and the hip surgeries performed in a Finnish cohort of children with cerebral palsy not followed up in a hip surveillance program and to compare these with previous studies performed in Northern European countries before and after the implementation of hip surveillance programs.Methods: A cross-sectional study. A coho

Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may play a role. The aim of this study was to compare concentrations of autoantibodies to cardiovascular G protein-coupled receptors between

Responsible Investing: Costs and Benefits. A Cross-Country Study in Europe.

This study employs the ESG-Sharpe Ratio frontiers framework and the ESG-adjusted CAPM model, introduced by Pedersen et al. (2020), to identify the costs and benefits of responsible investing and investigate the relationship between the environmental, social, and governance (ESG) issues and portfolio performance in different countries across Europe. In this paper, we explain the cross-country diffe