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Heat-shock protein 90 (HSP90) is a molecular chaperone that activates oncogenic transformation in several solid tumors, including lung and breast cancers. Ganetespib, a most promising candidate among several HSP90 inhibitors under clinical trials, has entered Phase III clinical trials for cancer therapy. Despite numerous evidences validating HSP90 as a target of anticancer, there are few studies o
Heat stress events will be more frequent and intense in the future. These events will challenge the capacity of organisms to exhibit sufficient metabolic flexibility to adapt to such variations. To better understand the acclimation processes implemented in response to acute warming, with an integrative approach we examined in vivo metabolic rate and cardiac mitochondrial respiration in the Rhône s
BackgroundShock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk of complications are high, the next treatment step is the use of vasopressors for stabilisation. Noradrenalin
Background: Development of secure attachment is crucial to establish and maintain healthy relationships with others throughout life. For parents with schizophrenia or bipolar disorder, challenged parental functioning may compromise the sensitive caregiving needed to establish secure child attachment. We aimed to examine pre-adolescent attachment, predictors related to caregiving, and middle childh
Polycyclic aromatic hydrocarbons (PAHs) have endocrine disrupting properties and they cross the placental barrier, but studies on gestational exposure and child anthropometry are inconclusive. We aimed to elucidate the impact of early gestational PAH exposure on anthropometry from birth to 10 years of age in 1295 mother-child pairs from a nested sub-cohort of the MINIMat trial in Bangladesh. Sever
In this paper we explore the potential of academic podcasting to effect positive change within academia and between academia and society. Building on the concept of “epistemic living spaces,” we consider how podcasting can change how we evaluate what is legitimate knowledge and methods for knowledge production, who has access to what privileges and power, the nature of our connections within acade
Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in the
Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD. Design, Setting
Jonatan Nästesjö: Vem i hela världen kan unga forskare lita på? Jonatan Nästesjö: Vem i hela världen kan unga forskare lita på? Av Caroline Cabot - Publicerad den 4 september 2024 Hur hanterar unga forskare osäkerheten kring vad det är som gäller inom akademin? Foto: Unsplash Hur lär sig unga forskare vad som är kvalitet i vetenskaplig publicering eller vad som lönar sig i den akademiska karriären
https://www.uvet.lu.se/article/vem-i-hela-vaerlden-kan-unga-forskare-lita-paa/ - 2026-07-21
Jonatan Nästesjö: Vad betyder egentligen tur i akademin? Jonatan Nästesjö: Vad betyder egentligen tur i akademin? Av Caroline Cabot - Publicerad den 8 oktober 2024 När allt känns som ett lotteri, då kan vi lika gärna hjälpa varandra. Så sa en postdoktor som Jonatan Nästesjö intervjuade. Foto: Unsplash Forskares prat om tur går stick i stäv med synen att framgång är ett resultat av prestation. Jona
https://www.uvet.lu.se/article/vad-betyder-egentligen-tur-i-akademin/ - 2026-07-21
Professor Mona Holmqvist i Helsingborgs Dagblad Professor Mona Holmqvist i Helsingborgs Dagblad Av Caroline Cabot - Publicerad den 25 november 2024 Adolfsfältskolan som ska byggas i Ängelholm blir Sveriges största mellanstadium. Vilka är egentligen fördelarna och nackdelarna med en renodlad 4–6-skola? Mona Holmqvist, professor i utbildningsvetenskap vid Lunds universitet, svarar. Läs hela artikeln
https://www.uvet.lu.se/article/professor-mona-holmqvist-i-helsingborgs-dagblad/ - 2026-07-23
Tina Gunnarsson disputerar Tina Gunnarsson disputerar Av Caroline Cabot - Publicerad den 7 april 2025 Den 11 april kl. 13:15 disputerar Tina Gunnarsson i utbildningsvetenskap. Disputationen äger rum i LUX C121. Avhandlingens titel är: Affordances and Limitations of Translanguaging and Writing Tools: A Study of Emergent Multilingual Students’ Writing in EFL Välkommen! Dela http://www.uvet.lu.se?
https://www.uvet.lu.se/article/tina-gunnarsson-disputerar/ - 2026-07-23
Denna rapport är en del av Folkhälsomyndighetens uppdrag om att sprida kunskapinom miljörelaterad hälsa för att främja en miljö som bidrar till en god och jämlikhälsa i befolkningen. Rapporten riktar sig främst till beslutsfattare och handläggaresom arbetar med miljörelaterad hälsa på nationell, regional och lokal nivå. Denutgör ett viktigt beslutsunderlag för prioriteringar och åtgärder inom detm
Varje individs rätt till sexuellt självbestämmande och sexuell integritet är utgångspunkten för den svenska gällande sexualbrottslagstiftningen. Avgörande för om en gärning är sexualbrott eller inte blir därför frågan om det finns ett samtycke till en sexuell handling. Trots att självbestämmanderätten är skyddsintresset krävs det i den nuvarande lagstiftningen att gärningsmannen använt sig av tvån
In recent years, Swedish criminal policy has become increasingly repressive, a development reflected in reforms that have affected the special treatment of children and young offenders. In July 2023, the inquiry SOU 2025:11 The Age of Criminal Responsibility was appointed with the task of considering and proposing a lowering of the age of criminal responsibility. The inquiry resulted in a proposal
In July 2023 the Supreme Court of Sweden (Högsta domstolen) decided not to grant leave to appeal in a case between Mats Fredlund and the Swedish Transport Workers Union (Svenska transportarbetareförbundet). The dispute originated when Mats Fredlund was expulsed from the union because of his political commitment on behalf of the Sweden Democrats (Sverigedemokra-terna). In a judgement from December
Through evidentiary proceedings according to 38 § LUL, the general court can examine whether a child under the age of 15 years has committed a crime. Since the action concerns a child under the age of criminal responsibility, the judgment cannot contain any criminal sanction. A new legislative amendment which entered into force on July 1, 2023, has expanded the possibility of evidentiary proceedin
Regleringen på aktiemarknaden grundar sig på tanken att samtliga marknadsaktörer ska behandlas lika och få tillgång till samma information samtidigt. Art. 17 MAR utgör exempel på reglering som syftar till att säkerställa denna likabehandling. Artikeln stadgar skyldighet för noterade bolag att offentliggöra insiderinformation och medger endast undantag under särskilda omständigheter. Övervakningen The regulations in the stock market are based on the idea that all market participants shall be treated equally and get access to the same information simultaneously. Article 17 in MAR constitutes an example of regulation that aims at ensuring equality between the market participants. According to the article, listed companies are obligated to disclose inside information and exceptions are only al
