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Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in t

Abstract: During the production of industrial hempseed oil, a press cake is formed as a byproduct, which is often used as animal feed although it contains a high amount of protein that could be used for human consumption. Extracting this valuable protein would reduce food waste and increase the availability of plant-based protein. A protein extraction process based on the pH-shift method was adapt

Background: Severe alpha-1-antitrypsin deficiency (AATD) is a genetic condition predisposing to chronic obstructive pulmonary disease (COPD) and liver disease. Its natural course is not well known. Our aim was to study the natural course of AATD by analyzing the clinical course in individuals with severe AATD identified by screening.Materials and Methods: Of the 1585 individuals included in the Sw

Accurate and up-to-date land cover maps inform and support effective management and policy decisions. Describing phenological changes in spectral response using time-series data may help to distinguish vegetation types, thereby allowing for more specificity within vegetation classification. In this research, we test this by classifying indigenous forest vegetation in New Zealand, using PlanetScope

BACKGROUND: Chemotherapy drug distribution varies greatly among individual patients. Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer. We then did a randomised trial to compare this individually tailored FEC regimen with conventional adjuvant chemotherapy followed by consolidation w

Context. The TOI-178 system consists of a nearby, late-K-dwarf with six transiting planets in the super-Earth to mini-Neptune regime, with radii ranging from ∼1.1 to 2.9 R⊕ and orbital periods between 1.9 and 20.7 days. All the planets, but the innermost one, form a chain of Laplace resonances. The fine-tuning and fragility of such orbital configurations ensure that no significant scattering or co

The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9.7 years, 68% men) were prospectively included and grouped in younger (15–44 years, n = 93) and middle-aged (45–60 years, n = 292). Arterial

BACKGROUND: In patients with non-invasive urothelial carcinoma of the prostatic urethra (PUC), treatment with Bacillus Calmette-Guérin (BCG) could be beneficial. OBJECTIVE: To assess the response rates to BCG in the different tumor stages, to describe the clinical impact of transurethral resection of the prostate (TURP) before BCG treatment, and to review the side effects of BCG treatment for PUC.

BACKGROUND: Middle-Eastern immigrants in Sweden are at increased risk for type 2 diabetes (T2D) and poor mental health. Physical activity not only prevents/delays onset of T2D but also shows favorable effects on mental health. However, the effects of a culturally adapted lifestyle intervention on mental health among Middle-Eastern immigrants have not been explored before. We aimed to study the eff

Uncultivated field margins are one of the most frequent non-crop habitat types in contemporary, highintensity agricultural landscapes and may therefore be important for the persistence of many farmland species. Managing field margins in a way that preserves, and preferably enhances, their value for biodiversity is therefore important. In the present study, we evaluate how the flora of uncultivated

The overall goal of this article is to demonstrate a state-of-the-art ultrahigh field (UHF) magnetic resonance (MR) protocol of the brain at 7.0 Tesla in multiple sclerosis (MS) patients. MS is a chronic inflammatory, demyelinating, neurodegenerative disease that is characterized by white and gray matter lesions. Detection of spatially and temporally disseminated T2-hyperintense lesions by the use

OBJECTIVE: Mortality caused by coronary artery disease has markedly decreased in recent years. However, a substantial proportion of patients suffering a coronary event (CE) die within the first day, most of them out of hospital. We aimed to investigate how established cardiovascular (CV) risk factors and CV autonomic indices associate with fatal versus non-fatal CEs in the population.METHODS: 33 0

Enhancing forest drought resilience is important for preserving ecosystem services in the face of climate change, but operational management methods for boreal forests aiming to preserve ecosystem services under drought are still largely missing. This study explores the use of satellite remote sensing to monitor vegetation stress phases related to drought progression and to quantify both short- an

Background: To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association. Methods: MEDLINE, EMBASE, CINAHL and SPORTDiscus were searched up until April 2017. Studies were included if they fulfilled the following criteria: the study 1) assessed the association

In the framework of the RECCAP2 initiative, we present the greenhouse gas (GHG) and carbon (C) budget of Europe. For the decade of the 2010s, we present a bottom-up (BU) estimate of GHG net-emissions of 3.9 Pg CO2-eq. yr−1 (using a global warming potential on a 100 years horizon), which are largely dominated by fossil fuel emissions. In this decade, terrestrial ecosystems acted as a net GHG sink o

Background: Negative affective processes may contribute to maintenance of paranoia in patients with psychosis, and vice versa. Successful treatment may break these pathological symptom networks. This study examined whether treatment with virtual reality based cognitive behavioral therapy (VR-CBT) for paranoia influences momentary affective states, and whether VR-CBT changes the adverse interplay b

Zinc isotope ratios were measured in the top sections of dated ombrotrophic peat cores in Finland to investigate their potential as proxies for atmospheric sources and to constrain post depositional processes affecting the geochemical record. The peat deposits were located in Hietajärvi, a background site well away from any point pollution source and representing 'background' conditions, in Outoku

Avancerad bildanalys ger förståelse för skadade meniskers beteende under belastning En uppfriskande joggingtur i skogen kan lätt förvandlas till något annat om man inte har styr på benen. Den stötdämpande menisken är en liten men ack så viktig struktur i knät som tyvärr också är känslig för skador och sjukdom. Ett nyligen utfört projekt har med hjälp av 3D-bilder tagna under belastning av meniskpThe knee menisci distribute and dampen mechanical loads. Vulnerability to injury and disease of the meniscus is a global issue, particularly concerning osteoarthritis. The connection between the breakdown of meniscal tissue and its mechanical response is not entirely understood. This thesis seeks to contribute to filling this knowledge gap by developing and implementing a digital volume correlatio

With increasing environmental awareness, building materials and their impact on the environment are increasingly coming into focus. This study presents a framework for comparing Life Cycle Assessment (LCA) through A1 - A5 stages from the perspective of Global Warming Potential (GWP) to assess the climate change potential of three facade systems of different building types (villas, medium-sized bui

I Sverige finns ett grundlagsstadgat skydd mot påtvingade kroppsliga ingrepp som omfattar i princip alla ingrepp som görs i hälso- och sjukvård. Det innebär att all hälso- och sjukvård måste ges med patientens samtycke eller med stöd i tvångslagstiftning. I dagsläget finns ingen möjlighet att ge vård till en patient som saknar kapacitet att lämna ett giltigt samtycke om inte tvångslagstiftningen äThe Swedish constitution provides a general protection against enforced interventions. This includes practically all interventions in healthcare. The result is that all medical interventions must be supported by the patient's consent or by law. Swedish law provides no solution if a patient lacks the mental capacity to give consent for an intervention and the laws regarding involuntary treatmen