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By using cells isolated from cancer patients and mixing them with a new technology called “OssiGel”, it is possible to engineer human mini-bones. These miniaturized organs consist of mature bone and marrow tissue and can be used as model to study the disease mechanisms behind cancers that arise in bone marrow or spread to the bones, and offer the personalized testing of new drugs. Paul Bourgine is

https://www.medicine.lu.se/article/miniature-bones-research-model-cancer - 2025-09-29

Insulin secretion into the bloodstream requires a protein called CD59. New research led by Lund University shows that the two protein variants that are responsible for this function of CD59 are affected in diabetes. The study has been recently published in PNAS. Insulin affects many bodily functions, and is required for survival. It causes cells to take up glucose from the blood, storage of energy

https://www.medicine.lu.se/article/newly-discovered-protein-variants-are-key-insulin-secretion - 2025-09-29

Researchers at Lund University in Sweden have developed a new method for studying age-related brain disorders. The researchers have focused on the neurodegenerative disorder Huntington’s disease and the results have now been published in the journal Brain. Basic medical research often faces the challenge of developing disease models that correspond to specific disease mechanisms or the disease to

https://www.medicine.lu.se/article/researchers-reprogram-human-skin-cells-aged-neurons-study-neurodegenerative-disorders - 2025-09-29

The environment in which breast cancer arises –the interplay between the patient’s BMI, tumour size and cancer-specific proteins –is of importance for the prognosis. This is shown in a study from Lund University in Sweden. The knowledge could further enhance precision medicine in breast cancer. Major advances in diagnostics and treatment have improved survival rates among breast cancer patients in

https://www.medicine.lu.se/article/tumour-environment-can-affect-breast-cancer-prognosis - 2025-09-29

A large amount of lungs donated yearly cannot be used for transplantation. Researchers at Skåne University Hospital and Lund University have conducted an animal study with results that give hope that more donor lungs could be used to save lives in the future. The researchers have started a pilot study to investigate if the treatment will have the same positive effects on human beings. About 190 or

https://www.medicine.lu.se/article/new-treatment-can-result-access-more-donor-lungs-and-fewer-complications-after-transplantations - 2025-09-29

In November 2021, a private foundation was established to promote scientific research in pancreatic cancer, gastroenterology, and pain management at Lund University. The foundation will be endowed with a total of SEK 40 million and will be managed by Lund University. Earlier this spring, the first grants from the foundation were distributed – approx. SEK 3 million will support the efforts of five

https://www.medicine.lu.se/article/sek-40-million-donation-faculty-medicine - 2025-09-29

The Royal Swedish Academy of Sciences has elected two new members of the Academy’s class for medical sciences. One of them is Malin Parmar, Professor of Cellular Neuroscience at Lund University. Together with her research group, Malin Parmar has conducted several groundbreaking studies on stem cells that have led to the development of new treatments for patients with Parkinson’s disease. Using kno

https://www.medicine.lu.se/article/malin-parmar-elected-royal-swedish-academy-sciences - 2025-09-29

Narrative medicine provides tools for clinicians to read patients better. 2022 Sandblom Prize Lecture will be given by pioneering Professor Rita Charon of Columbia University on the discipline that uses the arts to improve understanding. Clinicians trained in narrative medicine are more able to listen for what their patients tell them, to see from others’ perspectives – including patients and fami

https://www.medicine.lu.se/article/sandblom-prize-expanding-creativity-clinical-worlds-through-narrative-medicine - 2025-09-29

Impaired insulin secretion is closely associated with type 2 diabetes, but the process is not yet fully understood. A new study by researchers at Lund University shows that the Piezo1 ion channel regulates insulin secretion, which means it may be an important target for new diabetes treatments. Type 2 diabetes often occurs because the pancreatic beta cells are unable to produce enough effective in

https://www.medicine.lu.se/article/study-shows-piezo1-ion-channel-plays-important-role-insulin-secretion - 2025-09-29

B cells and the antibodies they produce play an important role in our immune system, protecting us from the microscopic enemies that make us ill. Uncovering how they form and are ‘programmed’ during development is key to better understanding the immune response to infections and vaccinations. A new study by researchers from Lund University in Sweden provides new insights into the origin and develo

https://www.medicine.lu.se/article/how-b-cells-are-programmed-early-life-can-impact-long-term-immune-health - 2025-09-29

Göran Jönsson, Professor of Molecular Oncology, has been granted SEK 31 million from the Knut and Alice Wallenberg Foundation to improve the effect of immunotherapy in the treatment of cancer patients. About 30 percent of melanoma patients with metastatic disease benefit from immunotherapy. At the same time, this means that 70 percent of all melanoma patients still lack effective treatment options

https://www.medicine.lu.se/article/sek-31-million-more-effective-immunotherapy-cancer-treatment - 2025-09-29

Locked fingers, known as trigger finger, are more common among people with diabetes than in the general population. A study led by Lund University in Sweden shows that the risk of being affected increases in the case of high blood sugar. The study has been published in Diabetes Care. Trigger finger means that one or more fingers, often the ring finger or thumb, ends up in a bent position that is d

https://www.medicine.lu.se/article/hands-people-diabetes-more-often-affected-trigger-finger - 2025-09-29

Professor Oksana Tymoshchuk came to Lund with her children as soon as the opportunity arose. She also wanted to help students from her home university escape the ongoing turmoil in Ukraine. Now four medical students have arrived to study here for six months with a full Erasmus scholarship. “It’s a fantastic opportunity, with such practical studies. The other week I got to stitch up a Cesarean!” “I

https://www.medicine.lu.se/article/ukrainian-medical-students-arrive-lund-after-lightning-fast-application-process - 2025-09-29

A large study led by Lund University in Sweden has shown that people with Alzheimer's disease can now be identified before they experience any symptoms. It is now also possible to predict who will deteriorate within the next few years. The study is published in Nature Medicine, and is very timely in light of the recent development of new drugs for Alzheimer's disease. It has long been known that t

https://www.medicine.lu.se/article/alzheimers-disease-can-be-diagnosed-symptoms-emerge - 2025-09-29

Researchers at Lund University in Sweden have identified one of the reasons why the childhood cancer neuroblastoma becomes resistant to chemotherapy. The findings are significant for how future treatments should be designed. The results have been published in Science Advances. Neuroblastoma is an aggressive cancer of the sympathetic nervous system, especially of the adrenal gland. Despite intense

https://www.medicine.lu.se/article/altered-cell-behaviour-behind-resistance-neuroblastoma - 2025-09-29

Sometimes healthcare professionals treat patients with opioids such as morphine to relieve symptoms, but there has been a lack of evidence as to whether this helps with severe chronic breathlessness. A randomised Phase 3 study conducted by Swedish and Australian researchers now finds that morphine does not reduce worst breathlessness. The study is published in JAMA. Long term shortness of breath i

https://www.medicine.lu.se/article/new-study-morphine-treatment-people-copd-and-severe-long-term-breathlessness - 2025-09-29

Two world-leading American researchers known respectively for their research within medical humanities, and the sensory nervous system and perception of pain and temperature have been named honorary doctors at the Faculty of Medicine. The honorary doctorates will be conferred on 26 May 2023. Ever since David Julius’ discovery of the temperature and pain receptor TRPV1, he has contributed crucial d

https://www.medicine.lu.se/article/honorary-doctors-named-faculty-medicine - 2025-09-29

Last year's Nobel celebration was a digital version, but this year David Julius, who won the Nobel prize in Medicine or Physiology in 2021, will travel to Stockholm for the festivities. In this interview he talks about what such a prize leads to, about the joy of curiosity-driven research that, although lacking guardrails, is full of creativity and opportunities – and about the similarity between

https://www.medicine.lu.se/article/his-interest-natural-products-led-nobel-prize - 2025-09-29

Southern Scandinavia and Northern Germany form a leading life science region with unique research infrastructures that can help transform research into innovation. There is especially a large unused potential for industrial and clinical researchers to use these unique facilities. The HALRIC consortium led by Lund University has now received EU funding to build collaborations between companies, hos

https://www.medicine.lu.se/article/11-million-euros-life-science-research-and-innovation-infrastructure-synergies-northern-europe - 2025-09-29

Researchers at Lund University in Sweden have discovered an antibody with the potential to protect against Strep A infection, as well as a rare form of antibody binding, that leads to an effective immune response against bacteria. The discovery could explain why so many Group A strep vaccines have failed. The results are published in EMBO Molecular medicine. Group A streptococci have several ways

https://www.medicine.lu.se/article/antibody-discovery-paves-way-new-therapies-against-group-streptococcal-infections - 2025-09-29