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Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes.

Gene fusions have been described in approximately one-third of soft tissue tumors (STT); of the 142 different fusions that have been reported, more than half are recurrent in the same histologic subtype. These gene fusions constitute pivotal driver mutations, and detailed studies of their cellular effects have provided important knowledge about pathogenetic mechanisms in STT. Furthermore, most fus

Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer

PURPOSE: The development of tumor-specific markers to select targeted therapies and to assess clinical outcome remains a significant area of unmet need. We evaluated the association of baseline circulating tumor cell (CTC) number with clinical characteristics and survival in patients with castrate metastatic disease considered for different hormonal and cytotoxic therapies. EXPERIMENTAL DESIGN: CT

Integrated Architecture for Industrial Robot Programming and Control

As robot control systems are traditionally closed, it is difficult to add supplementary intelligence. Accordingly, as based on a new notion of user views, a layered system architecture is proposed. Bearing in mind such industrial demands as computing efficiency and simple factory-floor operation, the control layers are parameterized by means of functional operators consisting of pieces of compiled

Olfaction in Aslian ideology and language

The cognitive- and neuro-sciences have supposed that the perceptual world of the individual is dominated by vision, followed closely by audition, but that olfaction is merely vestigial. Aslian-speaking communities (Austroasiatic, Malay Peninsula) challenge this view. For the Jahai — a small group of rainforest foragers — odor plays a central role in both culture and language. Jahai ideology revolv

Friction Models and Friction Compensation

This paper reviews friction phenomena and friction models of interest for automatic control. Particular emphasis is given to two recently developed dynamic friction models, the Bliman-Sorine model and the LuGre model. These models capture many frictional phenomena observed in laboratory experiments. The behaviors of the models in different situations are discussed in detail. Methods for friction c

Complications after minor salivary gland biopsy: a retrospective study of 630 patients from two Swedish centres

ObjectivesThe aims of the study were to investigate the prevalence of impaired sensation after minor salivary gland biopsy (MSGB) in two Swedish centres [Karolinska University Hospital (KUH) and Skåne University Hospital (SUH)] and to assess its impact on quality of life (QoL) and associated risk factors.MethodA questionnaire including questions regarding the presence of impaired sensation, impact

Outcome After Surgery for Acute Type A Aortic Dissection With or Without Primary Tear Resection

Background: The outcome in patients after surgery for acute type A aortic dissection without replacement of the part of the aorta containing the primary tear is undefined. Methods: Data of 1122 patients who underwent surgery for acute type A aortic dissection in 8 Nordic centers from January 2005 to December 2014 were retrospectively analyzed. The patients with primary tear location unfound, unkno

Aluminum-Allergen of the Year 2022

Exposure to elemental aluminum and its salts is unavoidable. Aluminum as a metal is present in transport, construction, packaging, and electronic equipment. Aluminum salts are present in consumer products, food items and drinking water, vaccines, drugs, and antiperspirants. Aluminum in vaccines and preparations for allergen-specific immunotherapy are the major sensitization sources. The predominen

Allogeneic hematopoietic cell transplantation in patients with myeloid/lymphoid neoplasm with FGFR1-rearrangement : a study of the Chronic Malignancies Working Party of EBMT

Allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative treatment for patients with myeloid/lymphoid neoplasm (MLN) with FGFR1 rearrangement, but data on overall results are limited. We report on the largest series of patients (n = 22) with FGFR1-rearranged MLN undergoing allo-HCT. Distribution according to cytogenetic subtype was: t(8;13) in 11 cases, t(8;22) in 7 cases, t(6

Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000–2019

Objectives: To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20 years. Materials and methods: Data on PeIN from the Swedish National Penile Cancer Register were analysed regarding treatment in relation to age, size of the PeIN lesion, localization of the PeIN lesion and complications using chi-square

What about the fellow eye in treatment of neovascular age-related macular degeneration? Analysis of data from the Swedish macula register

Purpose: To analyse the development of neovascular age-related macular degeneration (nAMD) in the fellow eye in patients initially presenting with unilateral nAMD, using data from the Swedish Macula Register. Methods: This observational study included data on treatment-naïve patients who initially underwent unilateral treatment for nAMD, and then required bilateral treatment, between 2010 and 2018

Evaluation of the creatinine-based chronic kidney disease in children (under 25 years) equation in healthy children and adolescents

Background: The Chronic Kidney Disease in children (CKiD) equation to estimate glomerular filtration rate eGFR = k × Ht / SCr (Ht = height in cm, SCr = serum creatinine in mg/dL), with fixed k = 0.413, has recently been optimized by introducing age/sex dependent k-values valid for young children up to young adults (the CKiD Under 25 years (CKiDU25) equation). Although the CKiD equation was designe