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Abstract Non-coding RNAs (ncRNAs) are involved in many diverse biological functions. In this thesis, my objectives were focused on the functional evaluation of two types of ncRNAs. First, the functional consequences of miR-944 regulation were evaluated in HeLa, a cervical cancer cell line. Results showed a reduced cell proliferation on miR-944 overexpression by using the WST-1 assay. In addition,

Abstract Peroxisome proliferator-activated receptor gamma (PPARγ) is expressed in multiple tumor cells as well as macrophages, and has been identified as a putative target for the development of novel therapies against colon cancer. Stimulation of the nuclear receptor PPARγ transcriptional activity can suppress colon carcinogenesis. To understand the molecular mechanisms underlying the anti-tumor

Abstract The yeast Dekkera/Brettanomyces bruxellensis is a distant relative of baker’s yeast Saccharomyces cerevisiae and either has positive or negative effects to beverage flavor development. D. bruxellensis and S. cerevisiae display several similar traits which play very important roles in food industry, such as production of high ethanol levels. In our lab, we determined and annotated the 13.

Lite mer än ett decennium efter skapandet av Napster är piratkopieringens ekonomiska inverkan på musikindustrins intäkter, konsumenternas välfärd och utbudet av ny musik fortfarande under debatt. Det finns en utbredd oro att omfattande piratkopiering leder till negativa långsiktiga välfärdseffekter för såväl producenter som konsumenter. I den här uppsatsen genomförs en kvalitativ studie av piratko

Uppsatsens syfte var att analysera hur läkemedelsassisterad behandling vid opiatberoende textuellt konstrueras och konstitueras genom språket i åtta textdokument producerade dels av Socialstyrelsen och dels av Region Skåne. Uppsatsen har en socialkonstruktionistisk hållning med en syn på språket som tillträde till den empiriska verkligheten vilket utgör utgångspunkt för det diskursanalytiska angreAuthor: Terese Farkas Title: Medication-assisted treatment for opiate dependence - A critical discourse analysis Supervisor: Leili Laanemets Assessor: Håkan Jönson och Torbjörn Hjort The aim of this study was to analyze how the medication-assisted treatment for opiate dependence textually constructed and constituted through language in a number of text documents produced partly by the National Boa

Varg (Canis lupus) i södra Sverige Efter att ha varit nästan utrotad från landet 1965 så har vargen nu stadigt återhämtat sig och ökar mer och mer i antal, dock finns den svenska varg populationen främst i mellersta Sverige. Men i samband med att populationen ökar så flyttar fler och fler djur söderut. Etableringen av rovdjur så som varg har visat sig ha stor positiv påverkan på ekosystem men ä

The goal of this dissertation is to estimate the amount of water in snowpacks at the areas Kultsjön and Rensaren in northen Sweden. A model is built using spatial statistics, and the estimations will be done by Integrated Nested Laplace Approximations (INLA). Then a validation process was done by removing data from the data set to create a validation set, and compare the estimations done by INLA t

Abstract: The zooplankton community of The Area of Multiple Use Hawaii (AUMH), South Pacific Coast of Guatemala mangrove channel ecosystem was studied in the dry season between February and March 2011. Zooplankton samples were taken during two lunar cycles, four tidal cycles (flood, high water (HW), ebb, low water (LW)), at four different sites. For each sampling occasion, salinity, pH, dissolved

BIOGEOGRAPHICAL DIVERSITY OF PLANT ASSOCIATED BACTERIAL COMMUNITIES ARCTIC TUNDRA Global warming is predicted to affect the Polar Regions most rapidly due to glacial retreat, snow cover reduction, melting of ice sheets and thawing of permafrost soils. Increase in temperature will further influence the native species to shift northerly by invasive pressure of species well adapted to warm temperat

I Skåne permanentades år 2008 vårdprogrammet höftlinjen vilket innebär att patienten redan på skadeplatsen gavs smärtlindring och förberedelser inför kommande operation startades. För att kunna utvärdera och förbättra den prehospitala omvårdnaden krävs forskning av patienternas upplevelse. Syfte: Att belysa patientens upplevelse av den prehospitala omvårdnaden vid höftfraktur. Metod: Elva semistru

ABSTRACT Soft tissue tumor-associated gene fusions are currently being used as diagnostic genetic markers and seem promising as potential prognostic markers. In the present study, a new fusion gene was discovered in one case of a specific subtype of soft tissue sarcoma displaying a t(6;16) translocation. Using fluorescence in situ hybridization (FISH), the FUS gene in 16p11 was shown to be rearra

Abstract Migration is a widespread phenomenon in nature, observed in many different taxa. Migration is often caused by changes in food availability, physical conditions and predation risks. Moving is energetically costly, and hence migration is likely to be a trade-off between increased survival and an energetic cost for migrating, the cost could take shape in decreased fecundity and lower body c

Popular science summary: Monitoring subcellular localization of Spx, YjbH, and ClpX in Bacillus subtilis Bacteria are exposed to continuous stress that causes damage to the cell. Therefore, they have developed stress responses that enable them to overcome stress and survive. Oxidizing elements is one kind of stress that bacteria have to deal with. To investigate how bacteria cope with this ki

Climate change induced migration is sometimes pictured as an urgent up-coming crisis that could result in waves of international refugees and violent conflicts, and sometimes as part of human history. It is a contested topic, an issue that divides actors and that still has no agreed upon definition. To get a better understanding of the debate, this thesis sets out to display the main discussions a

Abstract: The physiological responses of two Hong Kong acorn barnacles, Tetraclita japonica and T. squamosa differed under identical heat stress conditions. Both species experienced increased body temperature and mantle water osmolality with higher temperatures and prolonged emersion time. Species comparisons however, showed that T. japonica had warmer body temperatures and more concentrated osm

Aktivering av immunförsvaret dämpar den samme Kroppens immunförsvar består av en mängd olika typer av specialiserade celler, alla med sina unika egenskaper och nischer. För att immunförsvaret ska fungera så optimalt som möjligt krävs det att cellerna kan interagera och kommunisera med varandra, vilket görs med hjälp av proteiner som finns på cellernas yta. En typ av celler, som kallas CD8+ T cellAbstract 4-1BB (CD137/TNFRSF9) is a costimulatory receptor expressed by several cellular subsets of the immune system, but is commonly associated with CD8+ T cells. Stimulation of 4-1BB on CD8+ T cells with agonistic antibodies (α-4-1BB) causes a potent proliferation signal and an upregulated expression of CD11c. CD11c+CD8+ have previously been recognized to suppress other immune cells, such as F

Streptomyces belong to the phylum Actinobacteria, which are Gram-positive bacteria with GC-rich DNA. Most Streptomyces are strict aerobes and inhabit soil. They are known for production of a wide range of secondary metabolites, including antibiotics e.g. the macrolide erythromycin (S. erythraeus) or chloramphenicol (S. venezuelae). The typical smell of wet soil is owed to geosmin, also a secondary

Alzheimers sjukdom och nanopartiklar – blir vi dementa snabbare? Demenssjukdomar kommer märkbart att påverka vår allt mer åldrande befolkning. Alzheimers sjukdom är den vanligaste av dessa och leder till exempel till minnesförlust och förändrad personlighet. En sak som kännetecknar sjukdomen är bildandet av plack i hjärnan. Plack består av ihopklumpade protein. Proteinet som utgör dessa utgör desAbstract Alzheimer’s disease is a common form of dementia with one of its hallmarks being the formation of plaques in the brain consisting of fibrils formed from the amyloid beta peptide (Aβ). Nanoparticles have in vitro been shown to affect the rate of which these fibrils form. When nanoparticles enter a biological system they will be covered with proteins, a protein corona is formed. In this st