The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and N

Världens städer växer i snabb takt. Denna avhandling undersöker välbefinnandet och sårbarheten hos befolkningen i stadsnära, eller periurbana, låginkomstområden i och runt Bogotá, Colombia, med målet att öka förståelsen för hur sociala och miljömässiga förutsättningar påverkas av stadsutbredning och förtätning.För detta syfte har jag utvecklat en typologi för periurbana bosättningar som består av The world is rapidly urbanizing. To contribute to the understanding of the socio-environmental changes brought about by urban sprawl and densification, this thesis examines wellbeing and vulnerability in low-income peri-urban areas in and around Bogotá, Colombia. For that purpose, I develop a typology of peri-urban settlements that includes four main settlement classifications: agriculture-based,

Design fires are often used to the evaluate performance based designs by fire protection engineers all over the world and can be an invaluable tool if used properly. One potential big issue however is the fact that the exact same design fire is recommended by authorities in similar building types despite the fact that some building characteristics, such as building material, can differ greatly. Th

To explore the extent to which client characteristics, decision-maker attributes, and country influence judgments of institutional long-term care (ILTC) appropriateness for people with dementia. Design, setting, and participants: A total of 161 experts in dementia care from 8 European countries reviewed a series of 14 vignettes representing people with dementia on the cusp of ILTC admission and in

We consider the elliptic-elliptic, focussing Davey-Stewartson equations, which have an explicit bright line soliton solution. The existence of a family of periodic solitons, which have the profile of the line soliton in the longitudinal spatial direction and are periodic in the transverse spatial direction, is established using dynamical systems arguments. We also show that the line soliton is lin

Recent genome-wide association studies confirm that human leukocyte antigen (HLA) genes have the strongest associations with several autoimmune diseases, including type 1 diabetes (T1D), providing an impetus to reduce this genetic association to practice through an HLA-based disease predictive model. However, conventional model-building methods tend to be suboptimal when predictors are highly poly

Antalet äldre inom lantbruket ökar och med anledning av detta är det särskilt intressant att studera risker och olyckor utifrån ett åldersperspektiv. Syftet med denna studie var att kartlägga omfattningen och omständigheter kring olyckor, händelseförlopp samt typ av personskador i både lantbruks- och trafikmiljö.

Austroplaca subtiroliensis, Gyalidea lecideopsis, Phacographa protoparmeliae, Placynthium pulvinatum and Solorina octospora are reported new to Sweden. Several other rare or rarely collected lichens are also reported: Absconditella annexa, Arthrorhaphis vacillans, Farnoldia micropsis, Gyalidea polyspora, Ionaspis ventosa, Lecanora lecanoricola, L. leptacinella, Lecidea commaculans, Pachyascus lapp

Organic farming not only increases plant diversity, but also simultaneously promotes biological weed control through provisioning of ample resources to seed predators. Harpalus affinis (Schrank, 1781) was collected from organically or conventionally managed winter-wheat fields with high or low surrounding shares of organic fields, aiming to test the impact of agricultural management on its activit

Biodiversity indicators are assumed to reflect changes in e.g. species richness of multiple taxa, but correlations in species richness between taxa have often been shown to be weak. However, only few studies are based on data allowing for rigorous tests whether strengths of correlations differ between habitat and landscape factors. We compared strengths of correlations between species richness of

Local species richness of butterflies can be expected to benefit from both local habitat properties as well as the availability of suitable habitats and source populations in the surrounding landscape. Whether local species richness is dependent on local or landscape factors can be assessed by examining the relationship between local and landscape species richness. Here we studied how local specie

Despite considerable basic research into the mechanisms of atrial fibrillation (AF), not much progress has been made in the prognosis of patients with AF. With the exception of anticoagulant therapy, current treatments for AF still do not improve major cardiovascular outcomes. This may be due partly to the diverse aetiology of AF with increasingly more factors found to contribute to the arrhythmia

The set-aside obligation under the Common Agricultural Policy (CAP) brought widespread benefits for wild farmland species. Shortly after it was abolished in 2008, the national political process in Finland replaced it with a targeted agri-environment scheme for environmental fallow. Though potentially highly valuable, the value of the current scheme for securing biodiversity is yet to be confirmed.