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OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transport

We describe a computational imaging system for x-ray tomography, where image capture and post-processing are co-designed to improve final image quality when relative motion of an experiment’s components during a single exposure causes motion blur. The idea is based on temporally encoding the motion during each exposure by fluttering the detector shutter open and closed with a known sequence for gu

Swan bands-characteristic molecular absorption features of the C2 molecule-are a spectroscopic signature of carbon-enhanced stars. They can also be used to identify carbonenhanced metal-poor (CEMP) stars. The GALAH (GALactic Archaeology with Hermes) is a magnitude-limited survey of stars producing high-resolution, high-signal-to-noise spectra. We used 627 708 GALAH spectra to search for carbon-enh

Objective: Inconsistent reporting of outcomes in clinical trials of treatments for Whiplash Associated Disorders (WAD) hinders effective data pooling and conclusions that can be drawn about the effectiveness of tested treatments. The aim of this study was to provide recommendations for core outcome domains that should be included in clinical trials of WAD. Methods: A three-step process was used. 1

Background: Sportsman's hernia/athletic pubalgia is a recognized cause of chronic groin pain in athletes. Both open and laparoscopic surgical repairs have been described for treatment, but there are no comparative studies. The hypothesis here was that relief of pain would be achieved earlier in patients treated with open minimal suture repair than totally extraperitoneal repair. Methods: A randomi

Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on

□ The Nordic Arthroplasty Register Association (NARA) was established in 2007 by arthroplasty register representatives from Sweden, Norway and Denmark with the overall aim to improve the quality of research and thereby enhance the possibility for quality improvement with arthroplasty surgery. Finland joined the NARA collaboration in 2010. □ NARA minimal hip, knee and shoulder datasets were created

A tiny larva of ʻOrstenʼ-type of three-dimensional preservation has been recovered from the Upper Cambrian Bitiao Formation of Wangcun section, western Hunan, South China, herein in- terpreted as an orthonauplius stage of a crown-group crustacean. The specimen comprises an ovoid body with a prominent labrum and three pairs of appendages. In all it exhibits comparable morpho- logical similarities w

Ammonia (NH3) is regarded as one of the most viable alternatives to produce carbon-free energy. However, its low flammability and high NOx emissions associated with its combustion inhibit the implementation of pure NH3 as a fuel. Dual-fuel approaches with NH3 and more reactive fuels have been proposed; however, information on pollutant emissions is still scarce. The present work focuses on quantif

The housing sector is important for achieving ambitious environmental targets. In the European Union, buildings account for 40% of energy consumption and 36% of CO2 emissions. Considering the scale of the housing sector's environmental impact, interventions in how new housing is built and existing housing is renovated have great potential for sustainable transformation. However, the sector has not

Fire evacuations at wildland-urban interfaces (WUI) pose a serious challenge to the emergency services, and are a global issue affecting thousands of communities around the world. This paper presents a multi-physics framework for the simulation of evacuation in WUI wildfire incidents, including three main modelling layers: wildfire, pedestrians, and traffic. Currently, these layers have been mostl

Treated bamboo can be made into large, durable structural elements which have the potential to become a transformative large-scale building material, but the fracture behaviour which determines their ultimate strength in various loading scenarios has not been studied. Laminated bamboo is a promising structural engineered bamboo material, and is generally made from bamboo treated to improve its dur

In order to characterize the radium distribution and submarine groundwater discharge (SGD) in the Bohai Sea area, the three isotopes 223Ra, 224Ra and 228Ra in different water bodies were measured in a 4-year period with the radium-delayed coincidence counting (RaDeCC) system. The results indicated that radium activities take an order of groundwater > coastal seawater > river water > central seawat

Denna femte studie behandlar Supply chain information sharing (SCIS), d.v.s. hur företag delar information i försörjningskedjan. Vi försöker också förstå hur företag delar information i försörjningskedjan - både mellan företagets interna avdelningar/funktioner och med viktiga partners. Analysen bygger på svar från 34 panelmedlemmar.

The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision-makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an

Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulate

Den sjätte studien är fokuserad på Supply chain risk management (SCRM), d.v.s. vi försöker förstå hur företag identifierar, analyserar och hanterar risker i sin försörjningskedja. Det gäller både i Risk Management i interna logistikflöden (egna lager, egna fabriker, transporter mellan egna anläggningar etc) men framför allt Supply Chain Risk Management i externa försörjningskedjor (leverantörer, u