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Stressful Life Events and the Metabolic Syndrome - The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia Study

OBJECTIVE - Stress may play a role in the pathogenesis of the metabolic syndrome. However, the scant evidence available is not population-based, restricting the external validity of the findings. Our aim was to test associations between stressful life events, their accumulation, and the metabolic syndrome in a large population-based cohort. We also tested associations between stress and the indivi

Plasma lipid composition and risk of developing cardiovascular disease.

We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species.

Practical Applications of Asymmetrical Flow Field-Flow Fractionation (AF4): A Review

Characterization of macromolecules and colloids is an area of considerable interest. Asymmetrical flow field-flow fractionation (AF4) has become a well-established method, but many potential users possess limited knowledge of its capabilities, or how it can provide additional information or serve as validation to the traditional analytical techniques. This review article highlights several practic

Transcatheter Aortic Valve Implantation: Risk Assessment and Clinical Outcome

Abstract Background: Transcatheter aortic valve implantation (TAVI) has emerged as a treatment for patients with aortic stenosis (AS) and high surgical risk. To date, reports of short- and mid-term survival have been favourable. The aim of this thesis was to evaluate early safety, risk assessment and late survival following TAVI. Methods: In this work we studied clinical outcome, prediction of 3

Scalable, high performance, enzymatic cathodes based on nanoimprint lithography

Here we detail high performance, enzymatic electrodes for oxygen bio-electroreduction, which can be easily and reproducibly fabricated with industry-scale throughput. Planar and nanostructured electrodes were built on biocompatible, flexible polymer sheets, while nanoimprint lithography was used for electrode nanostructuring. To the best of our knowledge, this is one of the first reports concernin

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An overview in Danish of the process of integration of Skåne, Blekinge and Halland into the Swedish state after 1658.

Microstructure evolution during dynamic discontinuous recrystallization in particle-containing Cu

Control of the grain size in a material is vital in many engineering applications. Evolving through recrystallization, the grain size is strongly influenced by the presence of impurity particles. These particles exert drag forces on migrating grain boundaries and prevent grain boundary motion by pinning of the boundaries. Taking copper as example material, the present work establishes a novel simu

Searching for voltage graph-based LDPC tailbiting codes with large girth

The relation between parity-check matrices of quasi-cyclic (QC) low-density parity-check (LDPC) codes and biadjacency matrices of bipartite graphs supports searching for powerful LDPC block codes. Using the principle of tailbiting, compact representations of bipartite graphs based on convolutional codes can be found. Bounds on the girth and the minimum distance of LDPC block codes constructed in

Sexual health in Rheumatoid Arthritis - a physiotherapeutic approach

Popular Abstract in Swedish Reumatoid artrit (RA) även kallat ledgångsreumatism, är en ledsjukdom som innebär inflammationer i kroppens leder. Sjukdomens symptom är smärta, trötthet, nedsatt fysisk kapacitet med svullna, ömma leder. Kvinnor drabbas i större utsträckning av ledgångsreumatism än män. Sjukdomen är kronisk och behandlas med antireumatiska läkemedel samt kompletterande teambaserad behaThe overall aim of this thesis was to study how persons experience the influence of Rheumatoid Arthritis (RA) on their sexual health and their experiences of communication about sexual health, in order to improve physiotherapy within the field of rheumatology. Sexual health is an integrated part of life, and persons with Rheumatoid Arthritis, RA, often experience a decreased sexual health, which c

Multi-scale simulation of paperboard edge wicking using a fiber-resolving virtual paper model

When liquid packaging board is made aseptic in the filling machine, the unsealed edges of the board are exposed to hydrogen peroxide. A high level of liquid penetration may lead to aesthetic as well as functional defects. The ability to make a priori predictions about the edge wicking properties of a certain paperboard material is therefore of great interest to the paper industry, as well as to pa

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

Model-based detection of heart rate turbulence.

In this study, the integral pulse frequency modulation model is extended to account for the presence of ectopic beats and heart rate turbulence (HRT). Based on this model, a new statistical approach to the detection and characterization of HRT is presented. The detector structure involves a set of Karhunen-LoEve basis functions and a generalized likelihood ratio test statistic T(x) . The three mos

Satellite line mapping in Eu3+-Ce3+ and Pr3+-Ce3+ codoped Y2SiO5

In this work we perform a high-resolution spectroscopic investigation of Eu3+-Ce3+ and Pr3+-Ce3+ codoped Y2SiO5 crystals. Satellite line spectra were recorded at low temperatures around the Eu3+:F-7(0) -> D-5(0) and the Pr3+:H-3(4) -> D-1(2) transitions. It is observed that the incorporation of Ce3+ as a codopant notably changes the Eu3+ and Pr3+ satellite line patterns. Satellite lines measured i

Why Do Cuckolded Males Provide Paternal Care?

In most species, males do not abandon offspring or reduce paternal care when they are cuckolded by other males. This apparent lack of adjustment of paternal investment with the likelihood of paternity presents a potential challenge to our understanding of what drives selection for paternal care. In a comparative analysis across birds, fish, mammals, and insects we identify key factors that explain

Kartläggning och kvalitativ analys av möjligheter och risker med reducerad syrehalt i brandceller innehållande elektrisk utrustning

Fires can be an important hazard for the overall safe operation of nuclear power plants. Prevention of fire, fast detection and efficient extinguishment of a fire are some parameters, which are important to consider when designing the fire safety in a nuclear power plant. As an alternative to extinguishment system the use of hypoxic air or hypoxic air venting has been introduced e.g. in storage ro

Thermodynamically based fictitious crack/interface model for general normal and shear loading

For small deformations a crack/interface model that considers general 3D normal and shear loading is proposed. It involves elasticity, plasticity and damage and it is thermodynamically based. An essential feature of the model is its consistency with the concepts behind the fictitious crack model. In particular, no crack deformation occurs before the crack is initiated and when a crack has just bee

Tracking Performance of Several Combinations of Common Evaluation Metrics and Sub-pixel Methods

Motion estimation in a series of consecutive images is used in a variety of areas, e.g. video compression and investigation of tissue characteristics and organ function in medical images. Several methods exist both for estimating motions on a pixel level, e.g. block-matching in which two blocks in consecutive images are compared by an evaluation metric, and on a sub-pixel level. In this paper, we