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Long Term Behaviour of a Reversible System of Interacting Random Walks

This paper studies the long-term behaviour of a system of interacting random walks labelled by vertices of a finite graph. We show that the system undergoes phase transitions, with different behaviour in various regions, depending on model parameters and properties of the underlying graph. We provide the complete classification of the long-term behaviour of the corresponding continuous time Markov

Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes

A subset of genetic variants found through screening of patients with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome impact RNA splicing. Through target enrichment of the transcriptome, it is possible to perform deep-sequencing and to identify the different and even rare mRNA isoforms. A targeted RNA-seq approach was used to analyse the naturally-occurring splicing events

Empirical metronidazole for patients with severe bacterial infection : A systematic review with meta-analysis and trial sequential analysis

Background: Metronidazole is the preferred empirical anti-anaerobic agent for patients with suspected anaerobic infection. The balance between benefits and harms of empirical metronidazole is unclear. We aimed to assess patient-important benefits and harms of empirical metronidazole vs placebo/no treatment in adult patients with severe bacterial infection of any origin. Methods: We conducted a sys

90-Day readmission after radical prostatectomy—a prospective comparison between robot-assisted and open surgery

Purpose: All types of surgery are associated with complications. The debate is ongoing whether robot-assisted radical prostatectomy can lower this risk compared to open surgery. The objective of the present study was to evaluate post-operative adverse events leading to readmissions, using clinical records to classify these adverse events systematically. Materials and methods: A prospective control

Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis

Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethn

The Permafrost Young Researchers Network (PYRN) is getting older : The past, present, and future of our evolving community

A lasting legacy of the International Polar Year (IPY) 2007-2008 was the promotion of the Permafrost Young Researchers Network (PYRN), initially an IPY outreach and education activity by the International Permafrost Association (IPA). With the momentum of IPY, PYRN developed into a thriving network that still connects young permafrost scientists, engineers, and researchers from other disciplines.

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Stortingsmeldingen Kultur for kvalitet (Meld.st. 16. 2016-2017) stiller krav om at alle universiteter og høyskoler innen 2019 skal ha etablert meritteringssystemer som bidrar til at arbeidet med å utvikle god undervisning verdsettes. Hittil har tre norske universiteter innført meritteringsordninger – Norges arktiske universitet UiT, Universitetet i Bergen og NTNU. De norske meritteringssystemene b

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV

General and abdominal adiposity and the risk of Parkinson's disease : A prospective cohort study

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD. Methods: In 13 of the 23 centers of the European Prospective Investigation into C

Fully Decentralized Massive MIMO Detection Based on Recursive Methods

Algorithms for Massive MIMO uplink detection typically rely on a centralized approach, by which baseband data from all antennas modules are routed to a central node in order to be processed. In case of Massive MIMO, where hundreds or thousands of antennas are expected in the base-station, this architecture leads to a bottleneck, with critical limitations in terms of interconnection bandwidth requi

Kontinuerlig examination via automaträttade webbquizzar

Vi beskriver ett experiment att på en kurs i matematik införa veckovisa webbbaserade och automaträttade färdighetsprov i syfte att på ett kostnadseffektivt sätt introducera moment av löpande formativ bedömning i undervisningen och därigenom få studenterna att ligga bättre i fas och att hålla en jämnare arbetsbelastning under hela läsperioden.

Inequality in the aftermath of financial crises: some empirical evidence

Analyzing 70 countries over the period 1973–2006, we empirically show that, in the aftermath of financial crises, income inequality exhibits no general pattern of change. This holds for both advanced and emerging economies. However, when we break down the analysis by crisis types, we find that, after stock market crises, inequality goes down in advanced countries, while there is no statistically s

Career incentives in political hierarchy: evidence from Imperial Russia

This paper studies political career incentives in a nondemocratic historical setting to assess early political institutions. We construct a novel panel database of governors of Imperial Russia in 91 provinces between 1895 and 1914. Measuring an imperial governor’s performance by his ability of peacekeeping, we test whether the central authorities in the Russian Empire resorted to career incentives

Paediatric surgical care in Sweden. Studies on incidence, outcome and access

Abstract Background: Advanced paediatric surgery is increasingly centralised in Sweden in order to improve treatment outcomes and reduce surgical risks. However, the overall need for surgery in the paediatric population has not been estimated, and the association between geographic access to surgical facilities and timely treatment for common surgical conditions in children is largely unknown.