Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. This thesis focuses on the role of innate immune cells, and especially macrophages, in breast cancer. In the first pr

The reliable detection of neutrons in a harsh gamma-ray environment is an important aspect of establishing non-destructive methods for the characterization of spent nuclear fuel. In this study, we present results from extended in-situ monitoring of detector systems consisting of commercially available components: EJ-426, a 6Li-enriched solid-state scintillator material sensitive to thermal neutron

Yersinia enterocolitica is a food-borne Gram-negative pathogen responsible for several gastrointestinal disorders. Host-specific lytic bacteriophages have been increasingly used recently as an alternative or complementary treatment to combat bacterial infections, especially when antibiotics fail. Here, we describe the proteogenomic characterization and host receptor identification of the siphoviru

Binary star systems are assumed to be co-natal and coeval, and thus to have identical chemical composition. In this work, we aim to test the hypothesis that there is a connection between observed element abundance patterns and the formation of planets using binary stars. Moreover, we also want to test how atomic diffusion might influence the observed abundance patterns. We conduct a strictly line-

Identifying stars found in the Milky Way as having formed in situ or accreted can be a complex and uncertain undertaking. We use Gaia kinematics and APOGEE elemental abundances to select stars belonging to the Gaia-Sausage-Enceladus (GSE) and Sequoia accretion events. These samples are used to characterize the GSE and Sequoia population metallicity distribution functions, elemental abundance patte

This study is a continuation of our research on understanding the possible chemical routes to the evolution of life on earth based on the “Selective Energy Transfer” (SET) theory. This theory identifies the specific vibrational mode of the catalyst that is in energy-resonance with a suitable vibrational mode of the reactant. In this way, energy is transferred from catalyst to reactant up to the en

The Arctic is warming rapidly, especially in winter, which is causing large-scale reductions in snow cover. Snow is one of the main controls on soil thermodynamics, and changes in its thickness and extent affect both permafrost thaw and soil biogeochemistry. Since soil respiration during the cold season potentially offsets carbon uptake during the growing season, it is essential to achieve a reali

Anthropogenic nitrogen deposition is widely considered to increase CO2 sequestration by land plants on a global scale. Here, we demonstrate that bedrock nitrogen weathering contributes significantly more to nitrogen-carbon interactions than anthropogenic nitrogen deposition. This working hypothesis is based on the introduction of empirical results into a global biogeochemical simulation model over

We Review How Different Bat Guilds Respond To Artificial Light At Night (Alan) And Assess How The Impacts Can Vary According To Ecological Context. All Studied European Species Respond Negatively To Alan Close To Roosts And Drinking Sites, And The Impacts Occur Across A Wide Range Of Light Colors And Intensities. Most Bat Species Are Sensitive To Alan When Commuting And Foraging. Although Narrow-S

Avian migrants may fly at a range of altitudes, but usually concentrate near strata where a combination of flight conditions is favourable. The aerial environment can have a large impact on the performance of the migrant and is usually highly dynamic, making it beneficial for a bird to regularly check the flight conditions at alternative altitudes. We recorded the migrations between northern Europ

The vertebrate gut microbiota (bacterial, archaeal and fungal communities of the gastrointestinal tract) can have profound effects on the physiological processes of their hosts. Although relatively stable, changes in microbiome structure and composition occur due to changes in the environment, including exposure to stressors and associated increases in glucocorticoid hormones. Although a growing n

Combining studies of animal visual systems with exact imaging of their visual environment can get us a step closer to understand how animals see their “Umwelt”. Here, we have combined both methods to better understand how males of the speckled wood butterfly, Pararge aegeria, see the surroundings of their perches. These males are well known to sit and wait for a chance to mate with a passing femal

The study of plant mitochondria started in earnest around 1950 with the first isolations of mitochondria from animal and plant tissues. The first 35 years were spent establishing the basic properties of plant mitochondria and plant respiration using biochemical and physiological approaches. A number of unique properties (compared to mammalian mitochondria) were observed: (i) the ability to oxidize

In this study, several biodegradable Mg alloys (Mg5Zn, Mg5Zn0.3Ca, Mg5Zn0.15Ca, and Mg5Zn0.15Ca0.15Zr, numbers in wt%) were investigated after thermomechanical processing via high-pressure torsion (HPT) at elevated temperature as well as after additional heat treatments. Indirect and direct analyses of microstructure revealed that the significant strength increases arise not only from dislocations

There is an increasing interest in landscape-scale perspectives of ecosystem functioning to inform policy and conservation decisions. However, we need a better understanding of the stability of ecosystem functioning (e.g. plant productivity) at the landscape scale to inform policy around topics such as global food security. We investigate the role of the ecological and environmental context on lan

In nature, nothing is wasted, not even waste. Dung, composed of metabolic trash and leftovers of food, is a high-quality resource and the object of fierce competition. Over 800 dung beetle species (Scarabaeinae) compete in the South African dung habitat and more than 100 species can colonize a single dung pat. To coexist in the same space, using the same food, beetles divide the day between them.

Within Iran, the Zagros Mountains show high biodiversity, with a wealth of endemic species. One of these is the geometrid moth Somatina wiltshirei Prout, 1938, originally described from Iran and Iraq. In the present study, one mitochondrial and up to nine protein-coding nuclear gene regions were used along with a comparative morphological examination to investigate the systematic position of this