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A scheme for calculating the vibrational structure of electronic spectra using coupled-cluster response theory is proposed. To calculate the vibrational structure of electronic transitions, the optimized geometries of the two electronic states, the molecular Hessians, the dipole transition moment and (for vibrationally induced transitions) the geometrical gradient of the dipole transition moment a
Male mice homozygous for a mutated allele of the cyclin A 1 gene (Ccna 1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-1-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tub
The human kallikrein (hk) family, located on chromosome 19, encodes prostate-specific antigen (PSA [or hK3]), hK2, hK4, and hK15 (prostin), as well as other serine proteases. Although PSA has been used in the detection of prostate cancer for several years, much remains unknown about its function and forms. The regulatory mechanisms of PSA are vital to its understanding. A particular mechanism by w
Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a co
A multiwell tissue culture system was developed to study the influence of various substances on hepatitis A virus (HAV) propagation. A panel of 20 substances of different structure types, each with known effect against at least some viruses, was studied at a concentration of 100 microM. Three substances showed reproducible inhibition. The strongest inhibitor, arabinosylcytosine, also produced cyto
The angels still do not know how to sing during Christmas night. Some have three lines in Luke 2.14, others only two. Some have good liturgical hymns in their textbooks, others must use bad prose versions. This article reconstructs a Hebrew version with its focus on the righteous remnant of Israel, the "Anawim" in Jerusalem who saw Jesus as the beginning of the restoration of Israel, and goes on t
Objective: The novel axial flow left ventricular assist device HeartMate II was introduced into clinical practice in Europe as part of the pilot study and after CE approval in November 2005. In order to get an overview of the use and performance of the device in Europe a group of investigators was founded to compare the initial results. Methods: In a retrospective analysis of the first 101 consecu
In Sweden, Jurassic strata are restricted to Skåne and adjacent offshore areas. Jurassic sedimentary rocks predominantly comprise sandy to muddy siliciclastics, with subordinate coal beds and few carbonate-rich beds. During Mesozoic times, block-faulting took place in the Sorgenfrei– Tornquist Zone, a tectonic zone which transects Skåne in a NW–SE direction. The Jurassic depositional environments
This paper proposes a simple procedure to reduce the size distortions of the panel LM test for cointegration. The new procedure is based on first splitting the sample into even and odd numbered observations, and to employ the panel LM test to each subsample. The two tests are then combined using the Bonferroni principle as suggested by Choi [Choi, I., 2004, Improving the empirical size of the KPSS
In hereditary cystatin C amyloid angiopathy (HCCAA), presence of the Leu68 Gln substitution in cystatin C is coupled to a decreased concentration of this major cysteine proteinase inhibitor in cerebrospinal fluid and leads to its amyloid deposition in the brain. We established a high-yield expression system for L68Q cystatin C in Escherichia coli resulting in inclusion body accumulation at a level
C-CAM (Cell-CAM 105) is a cell surface glycoprotein that is involved in cell-cell adhesion of rat hepatocytes in vitro. To elucidate the adhesion mechanism the binding properties of purified C-CAM were investigated. Using proteins immobilized on nitrocellulose it was found that radiolabeled C-CAM bound to C-CAM but not to a variety of other proteins. Partitioning in Triton X-114 showed that C-CAM
The physical nature of water and the environment it presents to an organism have long been recognized as important constraints on aquatic adaptation and evolution. Little is known about the dermal cover of mosasauroids (a group of secondarily aquatic reptiles that occupied a wide array of predatory niches in the Cretaceous marine ecosystems 92-65 Myr ago), a lack of information that has hindered i
A new method is proposed for the computation of CO2 Net Ecosystem Exchange (NEE) and its components in a forest ecosystem. Advective flux is estimated by taking into account the air mass conservation principle. For this purpose, wind and dry air density values on the surface of the control volume are first corrected and then the advective flux is estimated on the surface of the control volume. Tur
Oocytes obtained from 85 women undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment were randomly selected for culture in media containing either human serum albumin (HSA), (n = 42) or recombinant human albumin (rHA), (n = 43). At the time of transfer, the two embryos with the overall best morphology were selected on day 2, 3 or 5. Comparable rates of fertilization, cleavage, blastocys
The hottest developments in the fields of cancer research, neuroscience, genomics and proteomics, anti-virals and more, with a pick of the key research papers in these areas.
The lifetime of the metastable level 3d(21)G(4) in a singly charged scandium has been experimentally investigated at the ion storage ring CRYRING. A laser probing technique has been used for the studies. We also report calculated lifetimes and transition rates for 10 metastable levels in Sc II, including the 3d(21)G(4) state, by calculations using configuration interaction wave functions. The life
