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Benefit From Reperfusion With Primary Percutaneous Coronary Intervention Beyond 12 Hours of Symptom Duration in Patients With ST-Segment-Elevation Myocardial Infarction

BACKGROUND: Guidelines recommend primary percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction (STEMI) presenting ≥12 hours of symptom onset in the presence of ongoing ischemia. However, data supporting this recommendation are limited. We evaluated the effect of primary PCI on reperfusion success, using cardiac magnetic resonance, in STEMI patients wi

Biomass-based energy on the move – The geographical expansion of the European Union’s liquid biofuel regulation

The growth of biomass-based markets for transport fuel is an expanding geographical process driven by regulation in the European Union (EU). Based on a certification scheme that illustrates the regulatory mechanisms in the EU’s liquid biofuel market, this article explains how larger processes of territorialisation and uneven development interact with specific processes of commodity production and

Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Heart Transplant Recipients

Background Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation, and the effect of different immunosuppressive regimens on CAV is not fully understood. The randomized SCHEDULE trial (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) evaluated whether initiation of the proliferation signal inhibitor everolimus and early c

The joint evolutionary histories of Wolbachia and mitochondria in Hypolimnas bolina

Background. The interaction between the Blue Moon butterfly, Hypolimnas bolina, and Wolbachia has attracted interest because of the high prevalence of male-killing achieved within the species, the ecological consequences of this high prevalence, the intensity of selection on the host to suppress the infection, and the presence of multiple Wolbachia infections inducing different phenotypes. We exam

National Innovation System Construction Process in Rwanda in an East African Region Context

The National Innovation System (NIS) is an interactive model of innovation that has the potential of better enhancing the use of knowledge for economic development. This approach is increasingly capturing the attention of developing economies as a means of utilizing knowledge for economic growth. This paper assesses how the NIS concept is being embraced in the East African (EA) region. It does so

Reacting boundary layers in a homogeneous charge compression ignition (HCCI) engine

An experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, tAn experimental and computational study of the near-wall combustion in a Homogeneous Charge Compression Ignition (HCCI) engine has been conducted by applying laser based diagnostic techniques in combination with numerical modeling. Our major intent was to characterize the combustion in the velocity- and thermal boundary layers. The progress of the combustion was studied by using fuel tracer LIF, t

Filial Daughter? Filial Son? How China’s Young Urban Elite Negotiate Intergenerational Obligations

This article deploys narrative method to explore how young adults in China enrolled in higher education negotiate future intergenerational obligations. The study finds that the process through which filial piety is being renegotiated is complex and sometimes contradictory, and norms and values do not always align with practices, as intergenerational obligations need to be managed in tandem with ob

You can't keep a good parasite down : Evolution of a male-killer suppressor uncovers cytoplasmic incompatibility

Maternally inherited parasites are known to impose a wide variety of reproductive manipulations upon their host. These often produce strong selection on the host to suppress the parasite, resulting in a reduction in the frequency of the parasite. However, in the butterfly Hypolimnas bolina, infected with a Wolbachia bacterium, field data demonstrate that suppression of the male-killing phenotype d

Male-Killing Bacteria Trigger a Cycle of Increasing Male Fatigue and Female Promiscuity

Sex-ratio distorters are found in numerous species and can reach high frequencies within populations. Here, we address the compelling, but poorly tested, hypothesis that the sex ratio bias caused by such elements profoundly alters their host's mating system. We compare aspects of female and male reproductive biology between island populations of the butterfly Hypolimnas bolina that show varying de