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Colon cancer is among the most lethal and prevalent malignant tumors in the world, and the lack of effective therapies highlights the need for novel therapeutic approaches. Schisandrin B (Sch B), a lignan extracted from the fruit ofSchisandra chinensis, has been reported for its anticancer properties. However, to date, no studies have been done to characterize the exact molecular mechanisms underl
Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants.
A radical transformation of the transport industry is required in order to achieve a fossil-fuel-free vehicle fleet and reach the greenhouse gas emissions goals. Electrification plays a crucial role in this radical process. An electric road system (ERS) is a road that supplies power to electric vehicles as they drive on it, offering numerous advantages. These include an extended driving range, dec
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction
This paper presents an experimental study where the mechanical behaviour of single-dowel timber connections made of acetylated Scots pine is compared with the behaviour of connections made from untreated Scots pine. The main aim was to evaluate the influence of the acetylation on the connection brittleness and also to compare the experimental results to the design provisions of the current Europea
The aim of this study was to add knowledge of the longitudinal associations between gaming and emotional closeness between parents and their children. We hypothesized that parent–child emotional closeness was linked to less gaming activity over time and that more gaming activity was linked to less parent–child emotional closeness over time. We also tested the moderating effect of child gender on t
This thesis comprises four self-contained papers that rely on applied micro-econometric methods to understand which factors are important in shaping the gender wage gap in globalized firms and how firms innovate when exposed to trade-induced shocks. In the first paper, we study how the within-firm gender wage gap in Sweden is affected by the degree of gender inequality in the home country of forei
This article examines how foreign policy branding is legitimated as a response to human rights crises. Drawing on legitimation theory (van Leeuwen, 2007), this study takes a discourse perspective with a focus on the enactment of foreign policy in communication and argues that legitimacy is the foundation for constructing a convincing and credible image of a country and its foreign policy. Building
In this study, the duality of adaptive capacity in aviation safety is examined, where the need for resilience of frontline workers conflicts with the expectations and assumptions of upstream entities, leading to system brittleness. We explore three critical categories: responsibilization, the application of practical wisdom in navigating challenging situations, and the unrecognized sacrifices that
The vector-boson production cross section for the Higgs boson decay in the Formula Presented channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at Formula Presented
We propose a notion of Misiurewicz condition for transcendental entire functions and study perturbations of Speiser functions satisfying this condition in their parameter spaces (in the sense of Eremenko and Lyubich). We show that every Misiurewicz entire function can be approximated by hyperbolic maps in the same parameter space. Moreover, Misiurewicz functions are Lebesgue density points of hype
This letter presents a measurement of the nuclear modification factor of large-radius jets in Formula Presented Formula Presented collisions by the ATLAS experiment. The measurement is performed using Formula Presented and Formula Presented of Formula Presented and Formula Presented data, respectively. The large-radius jets are reconstructed with the anti-Formula Presented algorithm using a radius
Enteral supplementation with arachidonic acid (AA) and docosahexaenoic acid (DHA) in extremely preterm infants has shown beneficial effects on retinopathy of prematurity and pulmonary outcome whereas exclusive DHA supplementation has been associated with increased pulmonary morbidity. This secondary analysis evaluates pulmonary outcome in 204 extremely preterm infants, randomized to receive AA (10
Introduction: The Interpersonal-Psychological Theory of Suicide proposes that capability for suicide is acquired through exposure to painful and provocative events (PPEs). Although there is robust evidence for a positive association between aggregate measures of PPEs and risk for suicidal behavior, little is known about the contributions of physical injuries. The present study investigated the rel
Sedimentary fans are key targets of exploration on Mars because they record the history of surface aqueous activity and habitability. The sedimentary fan extending from the Neretva Vallis breach of Jezero crater's western rim is one of the Mars 2020 Perseverance rover's main exploration targets. Perseverance spent ∼250 sols exploring and collecting seven rock cores from the lower ∼25 m of sediment
Introduction: Animal-assisted and nature-based interventions in psychosocial treatment for various groups of clients have been studied internationally. However, there is little knowledge about how young adults with autism experience participation in such types of interventions. This clinical study aimed to describe the feasibility of animal-assisted and nature-based activities on a farm as a compl
As future academics, Doctor of Philosophy (PhD) students are be expected to employ learning-centred approach as stated in the Paris Communique (2018) by the European ministers of education. The limited research available about doctoral students’ conceptions indicates that they range from content- to learning-centred. Although a few studies explored the factors which prompt students’ transformation
