Intrinsically disordered proteins (IDPs) adopt heterogeneous conformational ensembles in solution. The properties of the conformational ensemble are dependent upon the solution conditions, including the presence of ions, temperature, and crowding, and often directly impact biological function. Many in vitro investigations focus on the properties of IDPs under dilute conditions, rather than the cro

The problem of ‘naked statistical evidence’ is one of the most debated issues in evidence theory. Most evidence scholars agree that it is deeply problematic to base a verdict on naked statistical evidence, but they disagree on why it is problematic, and point to different characteristics of naked statistical evidence as the root of the problem. In this article, the author discusses the merits of dThe problem of ‘naked statistical evidence’ is one of the most debated issues in evidence theory. Most evidence scholars agree that it is deeply problematic to base a verdict on naked statistical evidence, but they disagree on why it is problematic, and point to different characteristics of naked statistical evidence as the root of the problem. In this article, the author discusses the merits of d

Cluster policies are widely used to strengthen regional competitiveness, yet difficult to evaluate. While academic approaches to cluster evaluation are often ignorant of the needs of policy-makers and practitioners, practitioner-led approaches often lack structure and rigour. As such, there remain significant gaps between theory and practice. The contribution of this paper is to reflect on a uniqu

Recension av Joe Kraus bok: The kosher Capones : a history of Chicago’s Jewish gangsters. Jämförelser mellan situationen i Chicago under 1900-talet och problemen med gängkriminalitet i dagens Sverige.

Circular building design could significantly reduce the environmental impact of buildings and the pressure on natural resources. However, most buildings today are not designed according to the principles of the circular economy. Most literature has focused on either methods for quantifying the lifecycle analysis of buildings and materials, or on innovative circular building materials, but not muchCircular building design could significantly reduce the environmental impact of buildings and the pressure on natural resources. However, most buildings today are not designed according to the principles of the circular economy. Most literature has focused on either methods for quantifying the lifecycle analysis of buildings and materials, or on innovative circular building materials, but not much

Vehicles equipped with sensors can participate in mobile crowdsourcing applications. Vehicular Ad Hoc Networks (VANETs) based on Dedicated Short Range Communication (DSRC) are used to carry sensing data. However, multi-hop transmissions for gathering data to Road Side Units (RSUs) in VANETs suffer from low data rate and long end-to-end delay, which can hardly meet the QoS requirements of delay-senVehicles equipped with sensors can participate inmobile crowdsourcing applications. Vehicular Ad Hoc Networks(VANETs) based on Dedicated Short Range Communication(DSRC) are used to carry sensing data. However, multi-hoptransmissions for gathering data to Road Side Units (RSUs) inVANETs suffer from low data rate and long end-to-end delay,which can hardly meet the QoS requirements of delay-sensitive

The full spatial structure and temporal evolution of the accretion flow into the envelopes of growing gas giants in their nascent discs is only accessible in simulations. Such simulations are constrained in their approach of computing the formation of gas giants by dimensionality, resolution, consideration of self-gravity, energy treatment and the adopted opacity law. Our study explores how a numb

Circumplanetary discs (CPDs) form around young gas giants and are thought to be the sites of moon formation as well as an intermediate reservoir of gas that feeds the growth of the gas giant. How the physical properties of such CPDs are affected by the planetary mass and the overall opacity is relatively poorly understood. In order to clarify this, we use the global radiation hydrodynamics code FA

Dust growth is often indirectly inferred observationally in star-forming environments,theoretically predicted to produce mm-sized particles in circumstellar discs, and also presumably witnessed by the predecessors of the terrestrial meteoritic record. For those reasons it is believed that young gas giants under formation in protoplanetary discs with putative circumplanetary discs (CPDs) surroundin

We know now that discs of gas and dust, so-called protoplanetary discs, form planets as side-products of the naturally occurring star formation process throughout the Milky Way. Young, growing planets in such discs are commonly referred to as protoplanets. In about 10\% of the so-far observed stars, this planet formation process leads to the occurrence of giant planets, such as Saturn, Jupiter, or

This study examined the longitudinal associations between non-suicidal self-injury (NSSI) in early adolescence and various positive and negative aspects of mental health in young adulthood. The participants were a cohort of regular school students (n = 1064) in grades 7–8 from a Swedish municipality. Nine hundred and ninety-one of these completed an 11-page questionnaire (T1: Mage = 13.7; 50.3% gi

Aim: Polypharmacy is becoming a global health problem. The aims of this study were to evaluate the temporal trends in the prevalence of polypharmacy in Sweden and to explore polypharmacy disparities by age, gender, education, and immigration status. Methods: Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014.

This Letter presents for the first time radio frequency (RF) reliability studies of fully integrated CMOS RF integrated circuits (RFICs) for next generation wireless communication applications involving conformal bodies where wireless communication RFICs will be embedded on ultra-thin flexible packages. As a test case, RF characteristics of a CMOS voltage-controlled oscillator (VCO) chip with mult

The clinical outcomes of primary immunodeficiencies (PIDs) are greatly improved by accurate diagnosis early in life. However, it is not common to consider PIDs before the manifestation of severe clinical symptoms. Including PIDs in the nation-wide newborn screening programs will potentially improve survival and provide better disease management and preventive care in PID patients. This calls for t

Adult health is influenced by factors during fetal life affecting organ development and birth weight. We aimed to study such factors in relation to adult respiratory disease (ARD) risk. The Helsingborg Birth Cohort, Sweden, contributed baseline data collected by medical staff through clinical examination and questionnaires on maternal and birth characteristics 1964-1967. Register linkages were per

Carriers of the hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) gene variant (rs72613567:TA) have a reduced risk of NASH and cirrhosis but not steatosis. We determined its effect on liver histology, lipidome, and transcriptome using ultra performance liquid chromatography-mass spectrometry and RNA-seq. In carriers and noncarriers of the gene variant, we also measured pathways of hepatic fatty acid

Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but all clinical trials have failed. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is classified as a medical food by the Europ

Although teachers’ well-being and vocal health are affected by noise, research on classroom sound environment from the teachers’ perspective is scarce. This study investigated the relationship between teachers’ well-being and classroom acoustics. The possible influence of teachers’ age, experience, teaching grade and class size on the relationship was also investigated. In this study, well-being r