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Regions vulnerable to climate change - findings and methodological considerations

The impacts of climate change will not be evenly spread around the globe. Instead, several studies point to some specific regions that are argued to be particularly vulnerable or prone to climate change-related conflict (‘hotspots’) The overarching aim of this report is to describe these regions and to look at the underlying methodology used by those studies when identifying the regional ‘hotspots

Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons

The focal and progressive degeneration of dopaminergic (DA) neurons in ventral midbrain has made Parkinson's disease (PD) a particularly interesting target of cell-based therapies. However, ethical issues and limited tissue availability have so far hindered the widespread use of human fetal tissue in cell-replacement therapy. DA neurons derived from human pluripotent stem cells (hPSCs) offer unpre

Defence on Demand : A physiological perspective on phenotypic plasticity in anti-predator traits

Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. Evolution has therefore favoured the development of phenotypic plasticity in anti-predator defences. The Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. Evolution has therefore favoured the development of phenotypic plasticity in anti-predator defences. The

Integrating the influence of weather into mechanistic models of butterfly movement

Background: Understanding the factors influencing movement is essential to forecasting species persistence in a changing environment. Movement is often studied using mechanistic models, extrapolating short-term observations of individuals to longer-term predictions, but the role of weather variables such as air temperature and solar radiation, key determinants of ectotherm activity, are generally

Data on the movement behaviour of four species of grassland butterfly

This Data in Brief article describes data on the movement behaviour of four species of grassland butterflies collected over three years and at four sites in southern England. The datasets consist of the movement tracks of Maniola jurtina, Aricia agestis, Pyronia tithonus, and Melanargia galathea, recorded using standard methods and presented as steps distances and turning angles. Sites consisted o

Elevated temperature increases genome-wide selection on de novo mutations

Adaptation in new environments depends on the amount of genetic variation available for evolution, and the efficacy by which natural selection discriminates among this variation. However, whether some ecological factors reveal more genetic variation, or impose stronger selection pressures than others, is typically not known. Here, we apply the enzyme kinetic theory to show that rising global tempe

Evaluating a trait-based approach to compare natural enemy and pest communities in agroforestry vs. arable systems

Diversified farming systems, for example those that incorporate agroforestry elements, have been proposed as a solution that could maintain and improve multiple ecosystem services. However, habitat diversification in and around arable fields has complex and inconsistent effects on invertebrate crop pests and their natural enemies. This hinders the development of policy recommendations to promote t

Cold spot microrefugia hold the key to survival for Brazil's Critically Endangered Araucaria tree

Brazil's Araucaria tree (Araucaria angustifolia) is an iconic living fossil and a defining element of the Atlantic Forest global biodiversity hotspot. But despite more than two millennia as a cultural icon in southern Brazil, Araucaria is on the brink of extinction, having lost 97% of its extent to 20th-century logging. Although logging is now illegal, 21st-century climate change constitutes a new

Effects of Temporal Expectations on the Perception of Motion Gestalts

Gestalt psychology has traditionally ignored the role of attention in perception, leading to the view that autonomous processes create perceptual configurations that are then attended. More recent research, however, has shown that spatial attention influences a form of Gestalt perception: the coherence of random-dot kinematograms (RDKs). Using ERPs, we investigated whether temporal expectations ex

Bertil Mårtensson

Presentation av författaren, och lektorn i teoretisk filosofi, Bertil Mårtensson.

European Communion and Planetary Organic Crisis

The most common way of theorising the European Union’s crises is to see them as, at best, a run of ‘bad luck’, or at worst as ‘multiple challenges’. This chapter brings two very different perspectives to the study of the European Union (EU) and its crises by theorising European (dis)integration using the Critical Social Theory (CST) of ‘European communion’ (Manners, 2013a) within the context of ‘p

Iranska regimens tentakler når ut till Europa och Sverige

Sverige måste revidera sin politik gentemot Iran. Samtidigt måste Säkerhetspolisen och Militära underrättelse- och säkerhetstjänsten få mer resurser för att kartlägga iranska operationer och aktiviteter i Sverige, skriver Ardavan Khoshnood.Sweden must revise its Iran policy. At the same time, the Swedish Security Police and the Military Intelligence and Security Service must be given more resources to map Iranian operations and activities in Sweden, writes Ardavan Khoshnood.

Bringing onco‐innovation to Europe’s healthcare systems : The potential of biomarker testing, real world evidence, tumour agnostic therapies to empower personalised medicine

Rapid and continuing advances in biomarker testing are not being matched by uptake in health systems, and this is hampering both patient care and innovation. It also risks costing health systems the opportunity to make their services more efficient and, over time, more economical. The potential that genomics has brought to biomarker testing in diagnosis, prediction and research is being realised,

Coupling ofN-tosylhydrazones with tetrazoles : synthesis of 2-β-d-glycopyranosylmethyl-5-substituted-2H-tetrazole type glycomimetics

Coupling reactions ofO-peracylated 2,6-anhydro-aldose tosylhydrazones (C-(β-d-glycopyranosyl)formaldehyde tosylhydrazones) with tetrazoles were studied under metal-free conditions using thermic or microwave activation in the presence of different bases. The reactions proved highly regioselective and gave the corresponding, up-to-now unknown 2-β-d-glycopyranosylmethyl-2H-tetrazoles in 7-67% yields.

Prevalence of exhaustion symptoms and associations with school level, length of work experience and gender: a nationwide cross-sectional study of Swedish principals

BACKGROUND: While poor mental health and psychiatric disorders attributed to stressful work conditions are a public health concern in many countries, the health consequences of the occupational stress experienced by school principals is an understudied issue. Although current data is lacking, some research suggests that principals have a stressful work situation that eventually may lead to burnout

Altered Tryptophan Catabolism in Placentas From Women With Pre-eclampsia

Background: The kynurenine pathway enzymes, breaking down tryptophan, are abundant in placental tissue. These metabolites are involved in immunoregulatory mechanisms, although the role of this pathway in pre-eclampsia (PE) has only begun to be characterized. Here, we determined tryptophan and metabolite levels together with the expression of kynurenine pathway enzymes and inflammatory factors in p