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https://www.ludc.lu.se/cardiovascular-research-translational-studies - 2025-10-21

Focal accumulation of immune cells and lipids in the vascular wall leads to the formation of atherosclerotic plaques. Plaques occasionally erode or rupture, causing the blood to clot and restrict blood flow, with serious clinical consequences such as acute myocardial infarctions and strokes. Even though our understanding of the disease mechanisms underlying atherosclerosis has advanced substantial

https://www.ludc.lu.se/research-0/experimental-cardiovascular-research/cardiovascular-research-cellular-metabolism-and-inflammation - 2025-10-21

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https://www.ludc.lu.se/research-0/experimental-cardiovascular-research/cardiovascular-research-matrix-and-inflammation-i-atherosclerosis - 2025-10-21

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https://www.ludc.lu.se/covid-tracker/read-more - 2025-10-21

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https://www.ludc.lu.se/covid-tracker/faq-0 - 2025-10-21

7,5 credits Bioinformatics, the application of computational methods to biological and biomedical problems, is a rapidly growing field. A large amount of data is being generated in the post genomic era through research in genomics, proteomics, and structural biology. It is therefore crucial that modern biochemists and biologists have knowledge of bioinformatics.This hands on course will give you a

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/dna-sequencing-informatics-ii-binp29 - 2025-10-21

15 credits The course Ecotoxicology is aiming to provide understanding and practical knowledge of the fate, uptake and effects of anthropogenic pollutants in the environment. We study and apply ecotoxicological theories, models, and common methods and approaches concerning: fate of pollutants in the environment using fugacity based multimedia partitioning models; uptake and accumulation using mode

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/ecotoxicology-bior41 - 2025-10-21

15 credits The central topic of the course is evolutionary theory and its ecological applications. We will focus on processes at both gene and individual level, with an emphasis on animals. The course is divided into different parts based on subject content. Evolutionary ecology. We start with the basics of Darwin's theory of evolution. Thereafter, we discuss central concepts such as natural and s

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/animal-ecology-bior91 - 2025-10-21

15 credits In this advanced course, you will learn how to reconstruct evolutionary history and test evolutionary hypotheses using a range of data and methods. You will also learn how evolutionary biology can be applied to meet outstanding challenges in medicine, conservation, biotechnology and sustainable development. The course is mandatory on the MSc programme in Evolutionary Biology.Course desc

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/evolutionary-biology-methods-and-applications-bior90 - 2025-10-21

15 credits Evolution affects biology at all levels – from genes to ecosystems. You will learn to analyse and understand the evolutionary processes that give rise to novelty, adaptation and diversity. In doing so you will learn how to unravel the evolutionary history of biological systems. The course is the first course on the MSc programme in Evolutionary Biology.Understanding evolution requires t

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/evolutionary-biology-patterns-and-processes-bior89 - 2025-10-21

15 credits Course description Why study immunology? Immunology is the study of the different biological structures and processes that together make up the immune system. The immune system plays a crucial role in our life by defending us from microorganisms and other parasites that might cause disease. In addition, the immune system provides protection against tumours. On the other hand, malfunctio

https://www.biologyeducation.lu.se/education/courses/advanced-level-courses/immunology-bior85 - 2025-10-21

Current positionGuest researcher, Biotech Research & Innovation Centre (BRIC), University of CopenhagenKate [dot] Herum [at] bric [dot] ku [dot] dkThesis titleSyndecan-4 in cardia fibroblasts - Role in regulation of extracellular matrix and myocardial stiffnessLists of papers included1) K.M. Herum, I.G. Lunde, B. Skrbic, G. Florholmen, D. Behmen, I. Sjaastad, C.R. Carlson, M.F. Gomez & G. Christen

https://www.ludc.lu.se/research-0/diabetic-complications/lab-alumni/kate-louise-moller-herum - 2025-10-21

We shall explore genetic function by a combination of genetic and functional assays. First, via expression profiling, we intend to determine which genes for mitochondrial proteins are altered in pancreatic β-cells, liver, skeletal muscle, and adipose tissue. This will be performed in material from i) humans with or without the disease, ii) in genetically or pharmacologically manipulated animals an

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/mitocondria - 2025-10-21

To accomplish these goals we will: A) establish the stimulus-secretion coupling in human pancreatic islets from non-diabetic organ donors to obtain proof of concepts derived from rodent studies; these data will also establish the gold standard for efforts to differentiate embryonic stem cells into mature islet cells. B) Combine islet studies with genetic and metabolic studies in humanA) Our knowle

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/islets - 2025-10-21

How do we get people from different cultures, industries and worlds to sit down and talk to each other? First, they need to be brought together, and this alone requires the right person for the job. Meet Paola Hjelt, member of Lund University Diabetes Centre’s Innovation Board, who talks about on how to accomplish a change of mindset. She grew up in Brussels, Belgium, has one degree from the Stock

https://www.ludc.lu.se/meetings-prerequisite-change - 2025-10-21

PI: Nils Wierup The emergence of morbidly obese patients has prompted novel approaches to achieve weight reduction. Given that energy reduction by dieting is largely unsuccessful in this paitent group, surgical procedures have instead been developed to dramatically restrict food intake. Indeed, over the course of months patients may loose up to 50% in body weight. In addition, the majority of pati

https://www.ludc.lu.se/about-us/action-groups/metabolic-surgery-action-group - 2025-10-21

PI: Albert Salehi The antiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors (also including nutritional and metabolic signals). It has been known for at long time that dysfunction fo pancreatic islets cell (α-, β- and δ-cell) is a critical factor in the development and progression of these diseases.One of the larg

https://www.ludc.lu.se/about-us/action-groups/gpcr-action-group - 2025-10-21

Glucolipotoxicity:We will identify defects in the regulation of adipose tissue lipid metabolism associated with obesity and diabetes using models with altered expression of hormone sensitive lipase (HSL), the rate-limiting step in lipolysis 39 and phosphodiesterase3B (PDE3B) 40-42, a key enzyme controlling insulin action HSL activity. Altered profiles of lipid derived second messengers and alterat

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/target-tissues - 2025-10-21

New drug targetsWe have in the different sections tested a number of pathways as putative new drug targets including exploring the role of TXNIP for the development of glucotoxicity in β-cells, muscle and kidney and the role of glucokinase in the β-cells. We have also explored the role of Ncf1 in thymus mediated control of tolerance. Potentially, all studied pathways can include regulatory steps w

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/therapy - 2025-10-21

Olle Melander’s group Our researchWhen type 2 diabetes has been determined, a patient’s absolute risk of future cardiovascular disease events remains very high despite available preventive therapies. Thus, primary prevention of diabetes appears instrumental in reducing the population burden of diabetes-related cardiovascular disease. This group focuses on identifying mechanisms causally related to

https://www.ludc.lu.se/research/cardiovascular-research-hypertension - 2025-10-21