Migraines constitute a common neurological and headache disorder affecting around 15% of the world’s population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which includes peripheral and central sensitization. There is therefore considerable evidence suggesting that inflammation in the intracranial meninges could be a k

Preterm infants show postnatal deficits of long-chain polyunsaturated fatty acids (LCPUFAs) which are essential for adequate growth and neurodevelopment. Human milk is a primary source of fatty acids (FAs) for the preterm infant, and therefore, knowledge about milk FA levels is required to design appropriate supplementation strategies. Here, we expanded on our previous study (Nilsson et al., 2018,

Over the past decade, our understanding of brain-waste clearance underwent a revolution after the discovery of the so-called glymphatic system. The glia-lymphatic (abbreviated, glymphatic) system was first described in 2012 as a paravascular macrosystem involved in the distribution of nutrients and clearance of metabolic waste from the brain parenchyma. The main actor of the system is the cerebros

We present a microfluidic system to control the position of particles (polystyrene beads or astrocyte cells) in hydrogel droplets using bulk acoustic standing waves. Droplets comprising hydrogel precursor solution, photoinitiator and (bio-)particles were generated and acoustic forces focused the beads to the droplet center line. Droplets were cross-linked by exposure to UV-light. With the acoustic

Much of the technology that makes robots reliable, human friendly, and industrialroboticsadaptable for numerous applications has emerged from manufacturers of industrial robots. With an estimated installation base in 2014 of about 1.5 million units, some 171000 new installations in that year and an annual turnover of the robotics industry estimated to be US$ 32 billion, industrial robots are by fa

This study investigates the development of the consonant inventories of a trilingual child acquiring Standard German, Swiss German and Italian simultaneously to find out whether and how mono- and trilingual acquisition differ. We examine our findings in the light of cross-linguistic interaction (CLI) and language separation in multilingual first language acquisition. To this end, longitudinal tril

Simulation-based imaging (SBI) is a blood flow imaging technique that optimally fits a computational fluid dynamics (CFD) simulation to low-resolution, noisy magnetic resonance (MR) flow data to produce a high-resolution velocity field. In this work, we study the effectivity of SBI in predicting wall shear stress (WSS) relative to standard magnetic resonance imaging (MRI) postprocessing techniques

Kármán vortex streets are repeating patterns of swirling vortices, appearing when a fluid passes an obstacle at Re>50. We present an array of interacting vortices, a Kármán vortex city, that arises when a DNA solution flows through an array of micro posts at Re

Background: Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival is below 30%, which has partly been attributed to cytarabine resistance. Preclinical data suggest that the addition of hydroxyurea potentiates cytarabine efficacy by increasing ara-C triphosphate (ara-CTP) levels through

BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is predominantly caused by desmosomal genetic variants, and clinical hallmarks include arrhythmias and systolic dysfunction. We aimed at studying the impact of the implicated gene(s) on the disease course. METHODS: The Nordic ARVC Registry holds data on a multinational cohort of ARVC families. The effects of genotype on electrocard

Background: Disordered gaming and problem gambling (DG/PG) are associated with a range of functional impairments as well as psychiatric comorbidity. With the proliferation of digital gaming apps aimed at children and adolescents, which involve in-game purchases, there is increasing evidence that DG/PG are on the rise in this age range. The behavior can be detected in youth presenting at school-bas

In 2014, the Swedish innovation agency Vinnova set up the program ‘Gender and Diversity for Innovation’, which has its roots in norm-critical innovation. In line with rationales for responsible innovation, a central aim of the program is to identify and challenge discriminatory norms to develop more inclusive and equal innovation processes. This article presents the findings of an in-depth analysi

This chapter covers prosodic features of languages across Southwestern, Central, and Northern Asia. One representative language from each of the four main language families is passed in review, Turkish (Turkic), Mongolian (Mongolic), Persian (Indo-European), and Georgian (Kartvelian). Owing to a lack of descriptive coverage of the prosody of languages in Central Asia, no comprehensive surveys are

In men from the general population, BMI has been associated with a lower sperm DNA fragmentation index (DFI). We wondered whether this could be due to estradiol, which is associated with BMI and reported important for sperm function. Our objective was to investigate the association between estradiol and DFI. In 2008–2010, we recruited 284 young men from the general population to deliver samples of

Aim: The aim of the study was to describe different eHealth literacy domains among parents of children needing paediatric surgery in Sweden, and the correlation between these eHealth literacy domains and parents' socioeconomic factors and demographic characteristics. Design: Descriptive correlational design. Method: Thirty-five Swedish-speaking parents participated as a historical control group wi

It is widely accepted that positive safety culture improves organizations’ safety performance and reduces the number of injuries and deaths. Safety culture has been well researched in high-risk industries; however, the hospitality industry until recently had no research of the concept unless related to food safety. This article explores theoretical grounds for research of safety culture in hospita

Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type (P1B-) ATPases are present in all kingdoms of life, facilitating cellular export of transition metals including copper. P-type ATPases follow an alternating access mechanism, with inward-facing E1 and outward-facing E2 conformations. Nevertheless, no structural information on E1 states is available for P1B-