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Direct neuronal reprogramming, by which a neuron is formed via direct conversion from a somatic cell without going through a pluripotent intermediate stage, allows for the possibility of generating patient-derived neurons. A unique feature of these so-called induced neurons (iNs) is the potential to maintain aging and epigenetic signatures of the donor, which is critical given that many diseases o

Low carbon input due to increasing specialization, intensification and reduced use of bio-fertilizer, leads to soil organic carbon (SOC) decreases in arable land. This is an emerging problem in Europe in general, where 45% of the EU soils have low and declining SOC content. SOC losses from agricultural soils influence soil fertility, putting food security at risk, and contributes to greenhouse gas

Risk for criminal behavior (CB), alcohol use disorder (AUD), and drug abuse (DA) are known to be familial. We know less about their transmission across three generations. We examined 844,109 probands born in Sweden 1980–1990, their parents, aunts/uncles, and grandparents for registration in population-based registers for CB, AUD, and DA. Mean tetrachoric relative-proband correlations (95% CIs) wer

Hard X-ray photoelectron spectroscopy (HAXPES) has been used to study the bulk electronic structure of thin molecular films of the organic compounds 2,2′,7,7′-tetrakis (N,N’-di-p-methoxyphenyl-amine)-9,9’-spiro-bifluorene (spiro-OMeTAD), 4-(diethylamino)-benzaldehyde-1,1)-diphenyl-hydrazone (DEH) and poly(3-hexylthiophene) (P3HT). Molecular layers of these compounds are hole conducting, a property

It is increasingly acknowledged that climate change is influencing terrestrial ecosystems by increased drought and rainfall intensities. Soil microbes are key drivers of many processes in terrestrial systems and rely on water in soil pores to fulfill their life cycles and functions. However, little is known on how drought and rainfall fluctuations, which affect the composition and structure of mic

© 2018 The Author(s). Background: Administration of antimicrobials to food-producing animals is regarded as a major contributor to the overall emergence of resistance in bacteria worldwide. However, few data are available on global antimicrobial use and resistance (AMR) in livestock, especially from low- and middle-income countries. Methods: We conducted a structured survey of 91 small-scale pig f

This study exploits policy reforms in Swedish primary care to examine the effect of pay-for-performance (P4P) on compliance with hypertension drug guidelines among public and private health care providers. Providers in regions with P4P are compared to providers in other regions in a difference-in-differences analysis using data from the Swedish Prescription Register for the period 2005-2013. The r

Standard signal processing techniques are implicitly based on the assumption that the signal lies on a regular, homogeneous domain. In practice, however, many signals lie on an irregular or inhomogeneous domain. An application area where data are naturally defined on an irregular or inhomogeneous domain is human brain neuroimaging. The goal in neuroimaging is to map the structure and function of t

The phase behavior in the oleic acid/sodium oleate/normal saline (0.15 M NaCl aqueous solution) system has been determined. For this purpose visual inspection of samples between crossed polarizers, and Small Angle X-ray diffraction was used to identify the various phases and their unit cell dimensions. A rich phase behavior was observed for the ternary system, featuring reverse micellar, micellar

The relatively new combustion concept known as partially premixed combustion (PPC) has high efficiency and low emissions. However, there are still challenges when it comes to fully understanding and implementing PPC. Thus a predictive combustion tool was used to gain further insight into the combustion process in late cycle mixing. The modeling tool is a stochastic reactor model (SRM) based on pro

Asylum seekers are often assigned to a locality in their host country directly upon arrival based on some type of uninformed dynamic matching system which does not take the background of the asylum seekers into consideration. This paper proposes an informed, intuitive, easy-to-implement and computationally efficient dynamic mechanism for matching asylum seekers to localities. This mechanism can be

Den här avhandlingen syftar till att utforska politiseringen av mark på lokal nivå i Kenya. Avhandlingen visar hur tillgång till mark legitimeras via berättelser om egendom (property) och tillhörighet (belonging). Begreppet djup politik (deep politics) används för att visa hur de här berättelserna inte bara förändrar synen på mark utan också synen på politik.De empiriska kapitlen beskriver hur staThis thesis aims to explore the politicization of land in a local setting in Kenya. The purpose is to study how access to land is justified through histories about relational property and belonging. The notion of deep politics is used in order to suggest that these histories of property and belonging not only transform the meanings of land but also the meanings of politics.The empirical chapters d

There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of h

Background: Adolescent anxiety and depression are highly prevalent psychiatric disorders that are associated with altered molecular and neurocircuit profiles. Recently, increased mitochondrial DNA copy number (mtDNA-cn) has been found to be associated with several psychopathologies in adults, especially anxiety and depression. The associations between mtDNA-cn and anxiety and depression have not,

Background: For metastatic germ cell tumour patients with intermediate prognosis (IPGCT) according to the IGCCCG classification 5-year overall survival (OS) rates of 79% were described, but recent data suggest significant changes. Patients and methods: To compare the outcome of current IPGCT with former patients and to find new prognosticators a retrospective observational study was performed. Eli

Recognizing and categorizing human actions is an important task with applications in various fields such as human-robot interaction, video analysis, surveillance, video retrieval, health care system and entertainment industry.This thesis presents a novel computational approach for human action recognition through different implementations of multi-layer architectures based on artificial neural net